LPS promotes a monocyte phenotype permissive for human cytomegalovirus immediate-early gene expression upon infection but not reactivation from latency
Abstract Human cytomegalovirus (HCMV) infection of myeloid cells is closely linked with the differentiation status of the cell. Haematopoietic progenitors and CD14+ monocytes are usually non-permissive for lytic gene expression which can lead to the establishment of latent infections. In contrast, d...
Saved in:
Main Authors: | V. G. Kew, M. R. Wills, M. B. Reeves |
---|---|
Format: | article |
Language: | EN |
Published: |
Nature Portfolio
2017
|
Subjects: | |
Online Access: | https://doaj.org/article/a3e630ac283b450d933d54c46cc8a72c |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Inhibition of the Super Elongation Complex Suppresses Herpes Simplex Virus Immediate Early Gene Expression, Lytic Infection, and Reactivation from Latency
by: Roberto Alfonso-Dunn, et al.
Published: (2020) -
Interferon-Responsive Genes Are Targeted during the Establishment of Human Cytomegalovirus Latency
by: Elizabeth G. Elder, et al.
Published: (2019) -
Tumor Necrosis Factor Alpha Induces Reactivation of Human Cytomegalovirus Independently of Myeloid Cell Differentiation following Posttranscriptional Establishment of Latency
by: Eleonora Forte, et al.
Published: (2018) -
Latency-Associated Expression of Human Cytomegalovirus US28 Attenuates Cell Signaling Pathways To Maintain Latent Infection
by: Benjamin A. Krishna, et al.
Published: (2017) -
A BMPR2/YY1 Signaling Axis Is Required for Human Cytomegalovirus Latency in Undifferentiated Myeloid Cells
by: Emma Poole, et al.
Published: (2021)