Patient individual phase gating for stereotactic radiation therapy of early stage non-small cell lung cancer (NSCLC)

Abstract Stereotactic body radiotherapy (SBRT) applies high doses and requires advanced techniques to spare surrounding tissue in the presence of organ motion. In this work patient individual phase gating is investigated. We studied peripheral and central primary lung tumors. The internal target vol...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	K. M. Kraus, M. Oechsner, J. J. Wilkens, K. A. Kessel, S. Münch, S. E. Combs
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a3eb53e756c64862a665a4a1c30cdbcb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a3eb53e756c64862a665a4a1c30cdbcb
record_format	dspace
spelling	oai:doaj.org-article:a3eb53e756c64862a665a4a1c30cdbcb2021-12-02T11:36:21ZPatient individual phase gating for stereotactic radiation therapy of early stage non-small cell lung cancer (NSCLC)10.1038/s41598-021-85031-w2045-2322https://doaj.org/article/a3eb53e756c64862a665a4a1c30cdbcb2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85031-whttps://doaj.org/toc/2045-2322Abstract Stereotactic body radiotherapy (SBRT) applies high doses and requires advanced techniques to spare surrounding tissue in the presence of organ motion. In this work patient individual phase gating is investigated. We studied peripheral and central primary lung tumors. The internal target volume (ITV) was defined including different numbers of phases picked from a 4D Computed tomography (CT) defining the gating window (gw). Planning target volume (PTV) reductions depending on the gw were analyzed. A treatment plan was calculated on a reference phase CT (rCT) and the dose for each breathing phase was calculated and accumulated on the rCT. We compared the dosimetric results with the dose calculated when all breathing phases were included for ITV definition. GWs including 1 to 10 breathing phases were analyzed. We found PTV reductions up to 38.4%. The mean reduction of the lung volume receiving 20 Gy due to gating was found to be 25.7% for peripheral tumors and 16.7% for central tumors. Gating considerably reduced esophageal doses. However, we found that simple reduction of the gw does not necessarily influence the dose in a clinically relevant range. Thus, we suggest a patient individual definition of the breathing phases included within the gw.K. M. KrausM. OechsnerJ. J. WilkensK. A. KesselS. MünchS. E. CombsNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q K. M. Kraus M. Oechsner J. J. Wilkens K. A. Kessel S. Münch S. E. Combs Patient individual phase gating for stereotactic radiation therapy of early stage non-small cell lung cancer (NSCLC)
description	Abstract Stereotactic body radiotherapy (SBRT) applies high doses and requires advanced techniques to spare surrounding tissue in the presence of organ motion. In this work patient individual phase gating is investigated. We studied peripheral and central primary lung tumors. The internal target volume (ITV) was defined including different numbers of phases picked from a 4D Computed tomography (CT) defining the gating window (gw). Planning target volume (PTV) reductions depending on the gw were analyzed. A treatment plan was calculated on a reference phase CT (rCT) and the dose for each breathing phase was calculated and accumulated on the rCT. We compared the dosimetric results with the dose calculated when all breathing phases were included for ITV definition. GWs including 1 to 10 breathing phases were analyzed. We found PTV reductions up to 38.4%. The mean reduction of the lung volume receiving 20 Gy due to gating was found to be 25.7% for peripheral tumors and 16.7% for central tumors. Gating considerably reduced esophageal doses. However, we found that simple reduction of the gw does not necessarily influence the dose in a clinically relevant range. Thus, we suggest a patient individual definition of the breathing phases included within the gw.
format	article
author	K. M. Kraus M. Oechsner J. J. Wilkens K. A. Kessel S. Münch S. E. Combs
author_facet	K. M. Kraus M. Oechsner J. J. Wilkens K. A. Kessel S. Münch S. E. Combs
author_sort	K. M. Kraus
title	Patient individual phase gating for stereotactic radiation therapy of early stage non-small cell lung cancer (NSCLC)
title_short	Patient individual phase gating for stereotactic radiation therapy of early stage non-small cell lung cancer (NSCLC)
title_full	Patient individual phase gating for stereotactic radiation therapy of early stage non-small cell lung cancer (NSCLC)
title_fullStr	Patient individual phase gating for stereotactic radiation therapy of early stage non-small cell lung cancer (NSCLC)
title_full_unstemmed	Patient individual phase gating for stereotactic radiation therapy of early stage non-small cell lung cancer (NSCLC)
title_sort	patient individual phase gating for stereotactic radiation therapy of early stage non-small cell lung cancer (nsclc)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a3eb53e756c64862a665a4a1c30cdbcb
work_keys_str_mv	AT kmkraus patientindividualphasegatingforstereotacticradiationtherapyofearlystagenonsmallcelllungcancernsclc AT moechsner patientindividualphasegatingforstereotacticradiationtherapyofearlystagenonsmallcelllungcancernsclc AT jjwilkens patientindividualphasegatingforstereotacticradiationtherapyofearlystagenonsmallcelllungcancernsclc AT kakessel patientindividualphasegatingforstereotacticradiationtherapyofearlystagenonsmallcelllungcancernsclc AT smunch patientindividualphasegatingforstereotacticradiationtherapyofearlystagenonsmallcelllungcancernsclc AT secombs patientindividualphasegatingforstereotacticradiationtherapyofearlystagenonsmallcelllungcancernsclc
_version_	1718395778814181376

Patient individual phase gating for stereotactic radiation therapy of early stage non-small cell lung cancer (NSCLC)

Ejemplares similares