IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression

T cells help B cells to differentiate into antibody-producing plasma cells. Here the authors show that T cells produce interleukin-2 to activate ERK/ELK1 and suppress BACH2 expression by modulating the BACH2 super-enhancer, thereby altering BACH2 downstream transcription programs for plasma cell dif...

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Autores principales:	Nicolas Hipp, Hannah Symington, Cédric Pastoret, Gersende Caron, Céline Monvoisin, Karin Tarte, Thierry Fest, Céline Delaloy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a3ec2df437fa44eea5f94d2e5946e484
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spelling	oai:doaj.org-article:a3ec2df437fa44eea5f94d2e5946e4842021-12-02T15:37:06ZIL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression10.1038/s41467-017-01475-72041-1723https://doaj.org/article/a3ec2df437fa44eea5f94d2e5946e4842017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01475-7https://doaj.org/toc/2041-1723T cells help B cells to differentiate into antibody-producing plasma cells. Here the authors show that T cells produce interleukin-2 to activate ERK/ELK1 and suppress BACH2 expression by modulating the BACH2 super-enhancer, thereby altering BACH2 downstream transcription programs for plasma cell differentiation.Nicolas HippHannah SymingtonCédric PastoretGersende CaronCéline MonvoisinKarin TarteThierry FestCéline DelaloyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicolas Hipp Hannah Symington Cédric Pastoret Gersende Caron Céline Monvoisin Karin Tarte Thierry Fest Céline Delaloy IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression
description	T cells help B cells to differentiate into antibody-producing plasma cells. Here the authors show that T cells produce interleukin-2 to activate ERK/ELK1 and suppress BACH2 expression by modulating the BACH2 super-enhancer, thereby altering BACH2 downstream transcription programs for plasma cell differentiation.
format	article
author	Nicolas Hipp Hannah Symington Cédric Pastoret Gersende Caron Céline Monvoisin Karin Tarte Thierry Fest Céline Delaloy
author_facet	Nicolas Hipp Hannah Symington Cédric Pastoret Gersende Caron Céline Monvoisin Karin Tarte Thierry Fest Céline Delaloy
author_sort	Nicolas Hipp
title	IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression
title_short	IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression
title_full	IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression
title_fullStr	IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression
title_full_unstemmed	IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression
title_sort	il-2 imprints human naive b cell fate towards plasma cell through erk/elk1-mediated bach2 repression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a3ec2df437fa44eea5f94d2e5946e484
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IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression

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