Increased VLCFA-lipids and ELOVL4 underlie neurodegeneration in frontotemporal dementia

Increased VLCFA-lipids and ELOVL4 underlie neurodegeneration in frontotemporal dementia

Abstract Rare, yet biologically critical, lipids that contain very long chain fatty acids (VLCFA-lipids) are synthesized in the brain by the enzyme ELOVL4. High levels of VLCFA-lipids are toxic to cells and excess VLCFA-lipids are actively removed by ABCD1 in an ATP-dependent manner. Virtually nothi...

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Bibliographic Details
Main Authors: Ying He, Katherine Phan, Surabhi Bhatia, Russell Pickford, YuHong Fu, Yue Yang, John R. Hodges, Olivier Piguet, Glenda M. Halliday, Woojin Scott Kim
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/a3ec9702bb7d490a87d9e995c901b490
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