Changes in parafoveal and peripapillary perfusion after decompression surgery in chiasmal compression due to pituitary tumors

Abstract We evaluated changes in parafoveal and peripapillary vessel density in chiasmal compression after decompression surgery using optical coherence tomography angiography (OCT-A). Sixty-two eyes with chiasmal compression for which preoperative and postoperative (4–6 months) OCT, OCT-A, visual f...

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Autores principales:	Ga-In Lee, Kyung-Ah Park, Sei Yeul Oh, Doo-Sik Kong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a3f06dedda954271b1ac108a25244f2e
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spelling	oai:doaj.org-article:a3f06dedda954271b1ac108a25244f2e2021-12-02T13:30:34ZChanges in parafoveal and peripapillary perfusion after decompression surgery in chiasmal compression due to pituitary tumors10.1038/s41598-021-82151-12045-2322https://doaj.org/article/a3f06dedda954271b1ac108a25244f2e2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82151-1https://doaj.org/toc/2045-2322Abstract We evaluated changes in parafoveal and peripapillary vessel density in chiasmal compression after decompression surgery using optical coherence tomography angiography (OCT-A). Sixty-two eyes with chiasmal compression for which preoperative and postoperative (4–6 months) OCT, OCT-A, visual field (VF), and comprehensive ophthalmic data were available, and 44 healthy eyes were evaluated. Vessel densities of the superficial retinal capillary plexus (SRCP), deep retinal capillary plexus (DRCP), and radial peripapillary capillary (RPC) segment were assessed using OCT-A. The postoperative measurements were compared with preoperative data. Preoperative peripapillary retinal nerve fiber layer, macular ganglion cell-inner plexiform layer thickness, and vessel densities of SRCP and RPC segments in patients’ eyes were significantly reduced compared to those of healthy controls (P < 0.0001, P < 0.0001, P = 0.0052, and P = 0.0085, respectively). Vessel densities were significantly decreased in the SRCP (P < 0.0001), DRCP (P = 0.0017), and RPC segments (P < 0.0001) after surgery compared to the preoperative values. Significant associations between the postoperative SRCP and DRCP vessel density changes and preoperative SRCP (r = − 0.3195, P = 0.0114) and DRCP (r = − 0.5165, P < 0.0001) vessel densities were found, respectively. There were also significant associations between postoperative SRCP vessel density changes and VF changes (r = − 0.2586, P = 0.0424). These findings indicate that decreased perfusion around the optic nerve head and on the macula associated with chiasmal compression could further progress after decompression surgery. Further functional and longer-term clinical studies are needed to elucidate the clinical implications of these findings.Ga-In LeeKyung-Ah ParkSei Yeul OhDoo-Sik KongNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ga-In Lee Kyung-Ah Park Sei Yeul Oh Doo-Sik Kong Changes in parafoveal and peripapillary perfusion after decompression surgery in chiasmal compression due to pituitary tumors
description	Abstract We evaluated changes in parafoveal and peripapillary vessel density in chiasmal compression after decompression surgery using optical coherence tomography angiography (OCT-A). Sixty-two eyes with chiasmal compression for which preoperative and postoperative (4–6 months) OCT, OCT-A, visual field (VF), and comprehensive ophthalmic data were available, and 44 healthy eyes were evaluated. Vessel densities of the superficial retinal capillary plexus (SRCP), deep retinal capillary plexus (DRCP), and radial peripapillary capillary (RPC) segment were assessed using OCT-A. The postoperative measurements were compared with preoperative data. Preoperative peripapillary retinal nerve fiber layer, macular ganglion cell-inner plexiform layer thickness, and vessel densities of SRCP and RPC segments in patients’ eyes were significantly reduced compared to those of healthy controls (P < 0.0001, P < 0.0001, P = 0.0052, and P = 0.0085, respectively). Vessel densities were significantly decreased in the SRCP (P < 0.0001), DRCP (P = 0.0017), and RPC segments (P < 0.0001) after surgery compared to the preoperative values. Significant associations between the postoperative SRCP and DRCP vessel density changes and preoperative SRCP (r = − 0.3195, P = 0.0114) and DRCP (r = − 0.5165, P < 0.0001) vessel densities were found, respectively. There were also significant associations between postoperative SRCP vessel density changes and VF changes (r = − 0.2586, P = 0.0424). These findings indicate that decreased perfusion around the optic nerve head and on the macula associated with chiasmal compression could further progress after decompression surgery. Further functional and longer-term clinical studies are needed to elucidate the clinical implications of these findings.
format	article
author	Ga-In Lee Kyung-Ah Park Sei Yeul Oh Doo-Sik Kong
author_facet	Ga-In Lee Kyung-Ah Park Sei Yeul Oh Doo-Sik Kong
author_sort	Ga-In Lee
title	Changes in parafoveal and peripapillary perfusion after decompression surgery in chiasmal compression due to pituitary tumors
title_short	Changes in parafoveal and peripapillary perfusion after decompression surgery in chiasmal compression due to pituitary tumors
title_full	Changes in parafoveal and peripapillary perfusion after decompression surgery in chiasmal compression due to pituitary tumors
title_fullStr	Changes in parafoveal and peripapillary perfusion after decompression surgery in chiasmal compression due to pituitary tumors
title_full_unstemmed	Changes in parafoveal and peripapillary perfusion after decompression surgery in chiasmal compression due to pituitary tumors
title_sort	changes in parafoveal and peripapillary perfusion after decompression surgery in chiasmal compression due to pituitary tumors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a3f06dedda954271b1ac108a25244f2e
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Changes in parafoveal and peripapillary perfusion after decompression surgery in chiasmal compression due to pituitary tumors

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