Safety and efficacy of testosterone gel in the treatment of male hypogonadism

Kishore M Lakshman, Shehzad BasariaSection of Endocrinology, Diabetes, and Nutrition. Boston University School of Medicine, Boston Medical Center, Boston, MA, USAAbstract: Transdermal testosterone gels were first introduced in the US in 2000. Since then, they have emerged as a favorable mode of test...

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Autores principales:	Kishore M Lakshman, Shehzad Basaria
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Testosterone gel Androgel Testim hypogonadism Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/a3f38ab65bf44289b982b69c16cd4fea
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spelling	oai:doaj.org-article:a3f38ab65bf44289b982b69c16cd4fea2021-12-02T01:17:52ZSafety and efficacy of testosterone gel in the treatment of male hypogonadism1178-1998https://doaj.org/article/a3f38ab65bf44289b982b69c16cd4fea2009-10-01T00:00:00Zhttps://www.dovepress.com/safety-and-efficacy-of-testosterone-gel-in-the-treatment-of-male-hypog-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Kishore M Lakshman, Shehzad BasariaSection of Endocrinology, Diabetes, and Nutrition. Boston University School of Medicine, Boston Medical Center, Boston, MA, USAAbstract: Transdermal testosterone gels were first introduced in the US in 2000. Since then, they have emerged as a favorable mode of testosterone substitution. Serum testosterone levels reach a steady-state in the first 24 hours of application and remain in the normal range for the duration of the application. This pharmacokinetic profile is comparable to that of testosterone patch but superior to injectable testosterone esters that are associated with peaks and troughs with each dose. Testosterone gels are as efficacious as patches and injectable forms in their effects on sexual function and mood. Anticipated increases in prostate-specific antigen with testosterone therapy are not significantly different with testosterone gels, and the risk of polycythemia is lower than injectable modalities. Application site reactions, a major drawback of testosterone patches, occur less frequently with testosterone gels. However, inter-personal transfer is a concern if appropriate precautions are not taken. Superior tolerability and dose flexibility make testosterone gel highly desirable over other modalities of testosterone replacement. Androgel and Testim, the two currently available testosterone gel products in the US, have certain brandspecific properties that clinicians may consider prior to prescribing.Keywords: testosterone gel, Androgel, Testim, hypogonadismKishore M LakshmanShehzad BasariaDove Medical PressarticleTestosterone gelAndrogelTestimhypogonadismGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 4, Pp 397-412 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Testosterone gel Androgel Testim hypogonadism Geriatrics RC952-954.6
spellingShingle	Testosterone gel Androgel Testim hypogonadism Geriatrics RC952-954.6 Kishore M Lakshman Shehzad Basaria Safety and efficacy of testosterone gel in the treatment of male hypogonadism
description	Kishore M Lakshman, Shehzad BasariaSection of Endocrinology, Diabetes, and Nutrition. Boston University School of Medicine, Boston Medical Center, Boston, MA, USAAbstract: Transdermal testosterone gels were first introduced in the US in 2000. Since then, they have emerged as a favorable mode of testosterone substitution. Serum testosterone levels reach a steady-state in the first 24 hours of application and remain in the normal range for the duration of the application. This pharmacokinetic profile is comparable to that of testosterone patch but superior to injectable testosterone esters that are associated with peaks and troughs with each dose. Testosterone gels are as efficacious as patches and injectable forms in their effects on sexual function and mood. Anticipated increases in prostate-specific antigen with testosterone therapy are not significantly different with testosterone gels, and the risk of polycythemia is lower than injectable modalities. Application site reactions, a major drawback of testosterone patches, occur less frequently with testosterone gels. However, inter-personal transfer is a concern if appropriate precautions are not taken. Superior tolerability and dose flexibility make testosterone gel highly desirable over other modalities of testosterone replacement. Androgel and Testim, the two currently available testosterone gel products in the US, have certain brandspecific properties that clinicians may consider prior to prescribing.Keywords: testosterone gel, Androgel, Testim, hypogonadism
format	article
author	Kishore M Lakshman Shehzad Basaria
author_facet	Kishore M Lakshman Shehzad Basaria
author_sort	Kishore M Lakshman
title	Safety and efficacy of testosterone gel in the treatment of male hypogonadism
title_short	Safety and efficacy of testosterone gel in the treatment of male hypogonadism
title_full	Safety and efficacy of testosterone gel in the treatment of male hypogonadism
title_fullStr	Safety and efficacy of testosterone gel in the treatment of male hypogonadism
title_full_unstemmed	Safety and efficacy of testosterone gel in the treatment of male hypogonadism
title_sort	safety and efficacy of testosterone gel in the treatment of male hypogonadism
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/a3f38ab65bf44289b982b69c16cd4fea
work_keys_str_mv	AT kishoremlakshman safetyandefficacyoftestosteronegelinthetreatmentofmalehypogonadism AT shehzadbasaria safetyandefficacyoftestosteronegelinthetreatmentofmalehypogonadism
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Safety and efficacy of testosterone gel in the treatment of male hypogonadism

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