Vascular risk modulates the relationship between cerebral amyloid deposition and subjective memory complaints

Jee Wook Kim,1,2 Min Soo Byun,3 Dahyun Yi,3 Jun Ho Lee,4 Kang Ko,4 Gijung Jung,5 Dong Young Lee3,4,6 On behalf of the KBASE Research Group 1Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Republic of Korea; 2Department of Psychiatry, Hallym University Coll...

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Autores principales:	Kim JW, Byun MS, Yi D, Lee JH, Ko K, Jung G, Lee DY
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Subjective memory complaints Amyloid beta (A) Vascular risk Alzheimer’s disease (AD) Cognitively normal. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/a3f5271276614b6c868fb322c92ed35b
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spelling	oai:doaj.org-article:a3f5271276614b6c868fb322c92ed35b2021-12-02T01:56:38ZVascular risk modulates the relationship between cerebral amyloid deposition and subjective memory complaints1178-2021https://doaj.org/article/a3f5271276614b6c868fb322c92ed35b2019-03-01T00:00:00Zhttps://www.dovepress.com/vascular-risk-modulates-the-relationship-between-cerebral-amyloid-depo-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jee Wook Kim,1,2 Min Soo Byun,3 Dahyun Yi,3 Jun Ho Lee,4 Kang Ko,4 Gijung Jung,5 Dong Young Lee3,4,6 On behalf of the KBASE Research Group 1Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Republic of Korea; 2Department of Psychiatry, Hallym University College of Medicine, Chuncheon, Republic of Korea; 3Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea; 4Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; 5Department of Nursing, Graduate School, Kyung Hee University, Seoul, Republic of Korea; 6Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea Purpose: We aimed to investigate the relationships of cerebral amyloid beta (Aβ) deposition and neurodegeneration (ND) with subjective memory complaints (SMCs) in cognitively normal (CN) individuals, focusing specially on the modulating effects of vascular risk (VR) on those relationships. Participants and methods: A total of 230 CN elderly individuals underwent comprehensive clinical assessments including the Subjective Memory Complaints Questionnaire (SMCQ), VR assessment, and multimodal brain imaging including [11C] Pittsburgh compound B positron emission tomography (PET), [18F] fluorodeoxyglucose-PET, and magnetic resonance imaging. Results: We found a significant overall positive association between cerebral Aβ retention and SMCQ score. In addition, we found a significant cerebral Aβ retention × VR interaction effect on the SMCQ score. Subgroup analyses showed that the Aβ–SMC association was found only in VR-negative, and not in VR-positive, individuals. We found no relationship between ND and SMCQ. Conclusion: Our findings suggest that SMC in CN elderly individuals reflects early accumulation of Aβ in the brain. Given the modulating effect of VR on the Aβ–SMC relationship, SMC can be used as a meaningful marker of early Aβ deposition in individuals without VR. Keywords: subjective memory complaints, amyloid beta, vascular risk, Alzheimer’s disease, cognitively normalKim JWByun MSYi DLee JHKo KJung GLee DYDove Medical PressarticleSubjective memory complaintsAmyloid beta (A)Vascular riskAlzheimer’s disease (AD)Cognitively normal.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 637-645 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Subjective memory complaints Amyloid beta (A) Vascular risk Alzheimer’s disease (AD) Cognitively normal. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Subjective memory complaints Amyloid beta (A) Vascular risk Alzheimer’s disease (AD) Cognitively normal. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kim JW Byun MS Yi D Lee JH Ko K Jung G Lee DY Vascular risk modulates the relationship between cerebral amyloid deposition and subjective memory complaints
description	Jee Wook Kim,1,2 Min Soo Byun,3 Dahyun Yi,3 Jun Ho Lee,4 Kang Ko,4 Gijung Jung,5 Dong Young Lee3,4,6 On behalf of the KBASE Research Group 1Department of Neuropsychiatry, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Republic of Korea; 2Department of Psychiatry, Hallym University College of Medicine, Chuncheon, Republic of Korea; 3Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea; 4Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea; 5Department of Nursing, Graduate School, Kyung Hee University, Seoul, Republic of Korea; 6Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea Purpose: We aimed to investigate the relationships of cerebral amyloid beta (Aβ) deposition and neurodegeneration (ND) with subjective memory complaints (SMCs) in cognitively normal (CN) individuals, focusing specially on the modulating effects of vascular risk (VR) on those relationships. Participants and methods: A total of 230 CN elderly individuals underwent comprehensive clinical assessments including the Subjective Memory Complaints Questionnaire (SMCQ), VR assessment, and multimodal brain imaging including [11C] Pittsburgh compound B positron emission tomography (PET), [18F] fluorodeoxyglucose-PET, and magnetic resonance imaging. Results: We found a significant overall positive association between cerebral Aβ retention and SMCQ score. In addition, we found a significant cerebral Aβ retention × VR interaction effect on the SMCQ score. Subgroup analyses showed that the Aβ–SMC association was found only in VR-negative, and not in VR-positive, individuals. We found no relationship between ND and SMCQ. Conclusion: Our findings suggest that SMC in CN elderly individuals reflects early accumulation of Aβ in the brain. Given the modulating effect of VR on the Aβ–SMC relationship, SMC can be used as a meaningful marker of early Aβ deposition in individuals without VR. Keywords: subjective memory complaints, amyloid beta, vascular risk, Alzheimer’s disease, cognitively normal
format	article
author	Kim JW Byun MS Yi D Lee JH Ko K Jung G Lee DY
author_facet	Kim JW Byun MS Yi D Lee JH Ko K Jung G Lee DY
author_sort	Kim JW
title	Vascular risk modulates the relationship between cerebral amyloid deposition and subjective memory complaints
title_short	Vascular risk modulates the relationship between cerebral amyloid deposition and subjective memory complaints
title_full	Vascular risk modulates the relationship between cerebral amyloid deposition and subjective memory complaints
title_fullStr	Vascular risk modulates the relationship between cerebral amyloid deposition and subjective memory complaints
title_full_unstemmed	Vascular risk modulates the relationship between cerebral amyloid deposition and subjective memory complaints
title_sort	vascular risk modulates the relationship between cerebral amyloid deposition and subjective memory complaints
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/a3f5271276614b6c868fb322c92ed35b
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Vascular risk modulates the relationship between cerebral amyloid deposition and subjective memory complaints

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