Cortical thickness, gyrification and sulcal depth in trigeminal neuralgia

Abstract Neuroimaging studies have documented brain structural alterations induced by chronic pain, particularly in gray matter volume. However, the effects of trigeminal neuralgia (TN), a severe paroxysmal pain disorder, on cortical morphology are not yet known. In this study, we recruited 30 TN pa...

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Autores principales:	Meng Li, Jianhao Yan, Hua Wen, Jinzhi Lin, Lianbao Liang, Shumei Li, Shuangcong Xie, Wuming Li, Chulan Lin, Guihua Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a3f57af8169b49c997e849c9d5cfdd25
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spelling	oai:doaj.org-article:a3f57af8169b49c997e849c9d5cfdd252021-12-02T19:06:42ZCortical thickness, gyrification and sulcal depth in trigeminal neuralgia10.1038/s41598-021-95811-z2045-2322https://doaj.org/article/a3f57af8169b49c997e849c9d5cfdd252021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95811-zhttps://doaj.org/toc/2045-2322Abstract Neuroimaging studies have documented brain structural alterations induced by chronic pain, particularly in gray matter volume. However, the effects of trigeminal neuralgia (TN), a severe paroxysmal pain disorder, on cortical morphology are not yet known. In this study, we recruited 30 TN patients and 30 age-, and gender-matched healthy controls (HCs). Using Computational Anatomy Toolbox (CAT12), we calculated and compared group differences in cortical thickness, gyrification, and sulcal depth with two-sample t tests (p < 0.05, multiple comparison corrected). Relationships between altered cortical characteristics and pain intensity were investigated with correlation analysis. Compared to HCs, TN patients exhibited significantly decreased cortical thickness in the left inferior frontal, and left medial orbitofrontal cortex; decreased gyrification in the left superior frontal cortex; and decreased sulcal depth in the bilateral superior frontal (extending to anterior cingulate) cortex. In addition, we found significantly negative correlations between the mean cortical thickness in left medial orbitofrontal cortex and pain intensity, and between the mean gyrification in left superior frontal cortex and pain intensity. Chronic pain may be associated with abnormal cortical thickness, gyrification and sulcal depth in trigeminal neuralgia. These morphological changes might contribute to understand the underlying neurobiological mechanism of trigeminal neuralgia.Meng LiJianhao YanHua WenJinzhi LinLianbao LiangShumei LiShuangcong XieWuming LiChulan LinGuihua JiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Meng Li Jianhao Yan Hua Wen Jinzhi Lin Lianbao Liang Shumei Li Shuangcong Xie Wuming Li Chulan Lin Guihua Jiang Cortical thickness, gyrification and sulcal depth in trigeminal neuralgia
description	Abstract Neuroimaging studies have documented brain structural alterations induced by chronic pain, particularly in gray matter volume. However, the effects of trigeminal neuralgia (TN), a severe paroxysmal pain disorder, on cortical morphology are not yet known. In this study, we recruited 30 TN patients and 30 age-, and gender-matched healthy controls (HCs). Using Computational Anatomy Toolbox (CAT12), we calculated and compared group differences in cortical thickness, gyrification, and sulcal depth with two-sample t tests (p < 0.05, multiple comparison corrected). Relationships between altered cortical characteristics and pain intensity were investigated with correlation analysis. Compared to HCs, TN patients exhibited significantly decreased cortical thickness in the left inferior frontal, and left medial orbitofrontal cortex; decreased gyrification in the left superior frontal cortex; and decreased sulcal depth in the bilateral superior frontal (extending to anterior cingulate) cortex. In addition, we found significantly negative correlations between the mean cortical thickness in left medial orbitofrontal cortex and pain intensity, and between the mean gyrification in left superior frontal cortex and pain intensity. Chronic pain may be associated with abnormal cortical thickness, gyrification and sulcal depth in trigeminal neuralgia. These morphological changes might contribute to understand the underlying neurobiological mechanism of trigeminal neuralgia.
format	article
author	Meng Li Jianhao Yan Hua Wen Jinzhi Lin Lianbao Liang Shumei Li Shuangcong Xie Wuming Li Chulan Lin Guihua Jiang
author_facet	Meng Li Jianhao Yan Hua Wen Jinzhi Lin Lianbao Liang Shumei Li Shuangcong Xie Wuming Li Chulan Lin Guihua Jiang
author_sort	Meng Li
title	Cortical thickness, gyrification and sulcal depth in trigeminal neuralgia
title_short	Cortical thickness, gyrification and sulcal depth in trigeminal neuralgia
title_full	Cortical thickness, gyrification and sulcal depth in trigeminal neuralgia
title_fullStr	Cortical thickness, gyrification and sulcal depth in trigeminal neuralgia
title_full_unstemmed	Cortical thickness, gyrification and sulcal depth in trigeminal neuralgia
title_sort	cortical thickness, gyrification and sulcal depth in trigeminal neuralgia
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a3f57af8169b49c997e849c9d5cfdd25
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Cortical thickness, gyrification and sulcal depth in trigeminal neuralgia

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