EEG microstate in obstructive sleep apnea patients

Abstract Obstructive sleep apnea (OSA) is a common sleep respiratory disease. Previous studies have found that the wakefulness electroencephalogram (EEG) of OSA patients has changed, such as increased EEG power. However, whether the microstates reflecting the transient state of the brain is abnormal...

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Autores principales:	Xin Xiong, Yuyan Ren, Shenghan Gao, Jianhua Luo, Jiangli Liao, Chunwu Wang, Sanli Yi, Ruixiang Liu, Yan Xiang, Jianfeng He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a3fb1ede649f464697e61209765d0c69
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spelling	oai:doaj.org-article:a3fb1ede649f464697e61209765d0c692021-12-02T19:02:27ZEEG microstate in obstructive sleep apnea patients10.1038/s41598-021-95749-22045-2322https://doaj.org/article/a3fb1ede649f464697e61209765d0c692021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95749-2https://doaj.org/toc/2045-2322Abstract Obstructive sleep apnea (OSA) is a common sleep respiratory disease. Previous studies have found that the wakefulness electroencephalogram (EEG) of OSA patients has changed, such as increased EEG power. However, whether the microstates reflecting the transient state of the brain is abnormal is unclear during obstructive hypopnea (OH). We investigated the microstates of sleep EEG in 100 OSA patients. Then correlation analysis was carried out between microstate parameters and EEG markers of sleep disturbance, such as power spectrum, sample entropy and detrended fluctuation analysis (DFA). OSA_OH patients showed that the microstate C increased presence and the microstate D decreased presence compared to OSA_withoutOH patients and controls. The fifth microstate E appeared during N1-OH, but the probability of other microstates transferring to microstate E was small. According to the correlation analysis, OSA_OH patients in N1-OH showed that the microstate D was positively correlated with delta power, and negatively correlated with beta and alpha power; the transition probability of the microstate B → C and E → C was positively correlated with alpha power. In other sleep stages, the microstate parameters were not correlated with power, sample entropy and FDA. We might interpret that the abnormal transition of brain active areas of OSA patients in N1-OH stage leads to abnormal microstates, which might be related to the change of alpha activity in the cortex.Xin XiongYuyan RenShenghan GaoJianhua LuoJiangli LiaoChunwu WangSanli YiRuixiang LiuYan XiangJianfeng HeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xin Xiong Yuyan Ren Shenghan Gao Jianhua Luo Jiangli Liao Chunwu Wang Sanli Yi Ruixiang Liu Yan Xiang Jianfeng He EEG microstate in obstructive sleep apnea patients
description	Abstract Obstructive sleep apnea (OSA) is a common sleep respiratory disease. Previous studies have found that the wakefulness electroencephalogram (EEG) of OSA patients has changed, such as increased EEG power. However, whether the microstates reflecting the transient state of the brain is abnormal is unclear during obstructive hypopnea (OH). We investigated the microstates of sleep EEG in 100 OSA patients. Then correlation analysis was carried out between microstate parameters and EEG markers of sleep disturbance, such as power spectrum, sample entropy and detrended fluctuation analysis (DFA). OSA_OH patients showed that the microstate C increased presence and the microstate D decreased presence compared to OSA_withoutOH patients and controls. The fifth microstate E appeared during N1-OH, but the probability of other microstates transferring to microstate E was small. According to the correlation analysis, OSA_OH patients in N1-OH showed that the microstate D was positively correlated with delta power, and negatively correlated with beta and alpha power; the transition probability of the microstate B → C and E → C was positively correlated with alpha power. In other sleep stages, the microstate parameters were not correlated with power, sample entropy and FDA. We might interpret that the abnormal transition of brain active areas of OSA patients in N1-OH stage leads to abnormal microstates, which might be related to the change of alpha activity in the cortex.
format	article
author	Xin Xiong Yuyan Ren Shenghan Gao Jianhua Luo Jiangli Liao Chunwu Wang Sanli Yi Ruixiang Liu Yan Xiang Jianfeng He
author_facet	Xin Xiong Yuyan Ren Shenghan Gao Jianhua Luo Jiangli Liao Chunwu Wang Sanli Yi Ruixiang Liu Yan Xiang Jianfeng He
author_sort	Xin Xiong
title	EEG microstate in obstructive sleep apnea patients
title_short	EEG microstate in obstructive sleep apnea patients
title_full	EEG microstate in obstructive sleep apnea patients
title_fullStr	EEG microstate in obstructive sleep apnea patients
title_full_unstemmed	EEG microstate in obstructive sleep apnea patients
title_sort	eeg microstate in obstructive sleep apnea patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a3fb1ede649f464697e61209765d0c69
work_keys_str_mv	AT xinxiong eegmicrostateinobstructivesleepapneapatients AT yuyanren eegmicrostateinobstructivesleepapneapatients AT shenghangao eegmicrostateinobstructivesleepapneapatients AT jianhualuo eegmicrostateinobstructivesleepapneapatients AT jiangliliao eegmicrostateinobstructivesleepapneapatients AT chunwuwang eegmicrostateinobstructivesleepapneapatients AT sanliyi eegmicrostateinobstructivesleepapneapatients AT ruixiangliu eegmicrostateinobstructivesleepapneapatients AT yanxiang eegmicrostateinobstructivesleepapneapatients AT jianfenghe eegmicrostateinobstructivesleepapneapatients
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EEG microstate in obstructive sleep apnea patients

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