COMPARATIVE ANALYSIS OF CEREBROSPINAL FLUID ADA LEVELS IN TUBERCULOUS AND NON-TUBERCULOUS MENINGITIS

Objective: To find out the association of Cerebrospinal Fluid (CSF) adenosine deaminase (ADA) Levels with tuberculosis meningitis. Study Design: Case control study. Place and Duration of Study: This study was conducted in the department of Medicine, Pak Emirates Military Hospital, Rawalpind...

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Autores principales:	Zahid Ullah, Shazia Nisar, Waseem Wali
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2018
Materias:	ada csf meningitis Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a3fb88a7dcaa466dacc53ef36d92fa88
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spelling	oai:doaj.org-article:a3fb88a7dcaa466dacc53ef36d92fa882021-11-26T03:17:12ZCOMPARATIVE ANALYSIS OF CEREBROSPINAL FLUID ADA LEVELS IN TUBERCULOUS AND NON-TUBERCULOUS MENINGITIS0030-96482411-8842https://doaj.org/article/a3fb88a7dcaa466dacc53ef36d92fa882018-12-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/2558/2096https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To find out the association of Cerebrospinal Fluid (CSF) adenosine deaminase (ADA) Levels with tuberculosis meningitis. Study Design: Case control study. Place and Duration of Study: This study was conducted in the department of Medicine, Pak Emirates Military Hospital, Rawalpindi over a period of six months from May to Oct 2015. Material and Methods: One hundred and ten participants i.e. 55 cases and 55 controls were included in the study. Lumbar puncture were done and 2cc CSF was obtained. CSF for routine examination and ADA levels were sent to a single lab and pathologist verified report. Based on CSF report, patients were classified as tuberculous meningitis (TBM) and Non- tuberculous meningitis and comparative analysis of ADA level were done in both groups. Results: Mean age of the patients was 51.33 ± 21.60 and 41.76 ± 18.66 in tuberculosis meningitis and non-tuberculosis meningitis participants. In Tuberculous Meningitis patients, 33 (60.0%) were males while in non Tuberculous Meningitis participants, 35 (63.6%) were males. Mean ADA level in CSF (13.71 ± 4.25 vs. 4.76 ± 3.49, p<0.001), cerebrospinal fluid (CSF) protein level (144.71 ± 99.15 vs 58.27 ± 15.62, p<0.001) and mean cell count (185.00 ± 97.29 vs. 73.71 ± 111.38, p<0.001) were significantly higher in Tuberculous meningitis patients as compared to non Tuberculous Meningitis participants. However, mean glucose was significantly (p<0.001) lower 29.42 ± 8.63 in Tuberculous Meningitis patients in comparison to 57.38 ± 9.13 non-tuberculous meningitis participants. Conclusion: In conclusion, the estimation of CSF-ADA level is a speedy and simple method, which can be confidently used for diagnosis of tuberculous etiology in TBM patients and differentiating it from non- tuberculous etiology.Zahid UllahShazia NisarWaseem WaliArmy Medical College RawalpindiarticleadacsfmeningitisMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 68, Iss 6, Pp 1614-1618 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	ada csf meningitis Medicine R Medicine (General) R5-920
spellingShingle	ada csf meningitis Medicine R Medicine (General) R5-920 Zahid Ullah Shazia Nisar Waseem Wali COMPARATIVE ANALYSIS OF CEREBROSPINAL FLUID ADA LEVELS IN TUBERCULOUS AND NON-TUBERCULOUS MENINGITIS
description	Objective: To find out the association of Cerebrospinal Fluid (CSF) adenosine deaminase (ADA) Levels with tuberculosis meningitis. Study Design: Case control study. Place and Duration of Study: This study was conducted in the department of Medicine, Pak Emirates Military Hospital, Rawalpindi over a period of six months from May to Oct 2015. Material and Methods: One hundred and ten participants i.e. 55 cases and 55 controls were included in the study. Lumbar puncture were done and 2cc CSF was obtained. CSF for routine examination and ADA levels were sent to a single lab and pathologist verified report. Based on CSF report, patients were classified as tuberculous meningitis (TBM) and Non- tuberculous meningitis and comparative analysis of ADA level were done in both groups. Results: Mean age of the patients was 51.33 ± 21.60 and 41.76 ± 18.66 in tuberculosis meningitis and non-tuberculosis meningitis participants. In Tuberculous Meningitis patients, 33 (60.0%) were males while in non Tuberculous Meningitis participants, 35 (63.6%) were males. Mean ADA level in CSF (13.71 ± 4.25 vs. 4.76 ± 3.49, p<0.001), cerebrospinal fluid (CSF) protein level (144.71 ± 99.15 vs 58.27 ± 15.62, p<0.001) and mean cell count (185.00 ± 97.29 vs. 73.71 ± 111.38, p<0.001) were significantly higher in Tuberculous meningitis patients as compared to non Tuberculous Meningitis participants. However, mean glucose was significantly (p<0.001) lower 29.42 ± 8.63 in Tuberculous Meningitis patients in comparison to 57.38 ± 9.13 non-tuberculous meningitis participants. Conclusion: In conclusion, the estimation of CSF-ADA level is a speedy and simple method, which can be confidently used for diagnosis of tuberculous etiology in TBM patients and differentiating it from non- tuberculous etiology.
format	article
author	Zahid Ullah Shazia Nisar Waseem Wali
author_facet	Zahid Ullah Shazia Nisar Waseem Wali
author_sort	Zahid Ullah
title	COMPARATIVE ANALYSIS OF CEREBROSPINAL FLUID ADA LEVELS IN TUBERCULOUS AND NON-TUBERCULOUS MENINGITIS
title_short	COMPARATIVE ANALYSIS OF CEREBROSPINAL FLUID ADA LEVELS IN TUBERCULOUS AND NON-TUBERCULOUS MENINGITIS
title_full	COMPARATIVE ANALYSIS OF CEREBROSPINAL FLUID ADA LEVELS IN TUBERCULOUS AND NON-TUBERCULOUS MENINGITIS
title_fullStr	COMPARATIVE ANALYSIS OF CEREBROSPINAL FLUID ADA LEVELS IN TUBERCULOUS AND NON-TUBERCULOUS MENINGITIS
title_full_unstemmed	COMPARATIVE ANALYSIS OF CEREBROSPINAL FLUID ADA LEVELS IN TUBERCULOUS AND NON-TUBERCULOUS MENINGITIS
title_sort	comparative analysis of cerebrospinal fluid ada levels in tuberculous and non-tuberculous meningitis
publisher	Army Medical College Rawalpindi
publishDate	2018
url	https://doaj.org/article/a3fb88a7dcaa466dacc53ef36d92fa88
work_keys_str_mv	AT zahidullah comparativeanalysisofcerebrospinalfluidadalevelsintuberculousandnontuberculousmeningitis AT shazianisar comparativeanalysisofcerebrospinalfluidadalevelsintuberculousandnontuberculousmeningitis AT waseemwali comparativeanalysisofcerebrospinalfluidadalevelsintuberculousandnontuberculousmeningitis
_version_	1718409987013738496

COMPARATIVE ANALYSIS OF CEREBROSPINAL FLUID ADA LEVELS IN TUBERCULOUS AND NON-TUBERCULOUS MENINGITIS

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