Nascent RNA sequencing identifies a widespread sigma70-dependent pausing regulated by Gre factors in bacteria

Transcription by bacterial RNA polymerase is interrupted by pausing events that play diverse regulatory roles. Here, the authors find that a large number of E. coli sigma70-dependent pauses, clustered at a 10−20-bp distance from promoters, are regulated by Gre cleavage factors constituting a mechani...

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Autores principales:	Zhe Sun, Alexander V. Yakhnin, Peter C. FitzGerald, Carl E. Mclntosh, Mikhail Kashlev
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a3fc4f3397f444a2a4e04ebfd6d6f34c
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spelling	oai:doaj.org-article:a3fc4f3397f444a2a4e04ebfd6d6f34c2021-12-02T13:30:20ZNascent RNA sequencing identifies a widespread sigma70-dependent pausing regulated by Gre factors in bacteria10.1038/s41467-021-21150-22041-1723https://doaj.org/article/a3fc4f3397f444a2a4e04ebfd6d6f34c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21150-2https://doaj.org/toc/2041-1723Transcription by bacterial RNA polymerase is interrupted by pausing events that play diverse regulatory roles. Here, the authors find that a large number of E. coli sigma70-dependent pauses, clustered at a 10−20-bp distance from promoters, are regulated by Gre cleavage factors constituting a mechanism for rapid response to changing environmental cues.Zhe SunAlexander V. YakhninPeter C. FitzGeraldCarl E. MclntoshMikhail KashlevNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhe Sun Alexander V. Yakhnin Peter C. FitzGerald Carl E. Mclntosh Mikhail Kashlev Nascent RNA sequencing identifies a widespread sigma70-dependent pausing regulated by Gre factors in bacteria
description	Transcription by bacterial RNA polymerase is interrupted by pausing events that play diverse regulatory roles. Here, the authors find that a large number of E. coli sigma70-dependent pauses, clustered at a 10−20-bp distance from promoters, are regulated by Gre cleavage factors constituting a mechanism for rapid response to changing environmental cues.
format	article
author	Zhe Sun Alexander V. Yakhnin Peter C. FitzGerald Carl E. Mclntosh Mikhail Kashlev
author_facet	Zhe Sun Alexander V. Yakhnin Peter C. FitzGerald Carl E. Mclntosh Mikhail Kashlev
author_sort	Zhe Sun
title	Nascent RNA sequencing identifies a widespread sigma70-dependent pausing regulated by Gre factors in bacteria
title_short	Nascent RNA sequencing identifies a widespread sigma70-dependent pausing regulated by Gre factors in bacteria
title_full	Nascent RNA sequencing identifies a widespread sigma70-dependent pausing regulated by Gre factors in bacteria
title_fullStr	Nascent RNA sequencing identifies a widespread sigma70-dependent pausing regulated by Gre factors in bacteria
title_full_unstemmed	Nascent RNA sequencing identifies a widespread sigma70-dependent pausing regulated by Gre factors in bacteria
title_sort	nascent rna sequencing identifies a widespread sigma70-dependent pausing regulated by gre factors in bacteria
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a3fc4f3397f444a2a4e04ebfd6d6f34c
work_keys_str_mv	AT zhesun nascentrnasequencingidentifiesawidespreadsigma70dependentpausingregulatedbygrefactorsinbacteria AT alexandervyakhnin nascentrnasequencingidentifiesawidespreadsigma70dependentpausingregulatedbygrefactorsinbacteria AT petercfitzgerald nascentrnasequencingidentifiesawidespreadsigma70dependentpausingregulatedbygrefactorsinbacteria AT carlemclntosh nascentrnasequencingidentifiesawidespreadsigma70dependentpausingregulatedbygrefactorsinbacteria AT mikhailkashlev nascentrnasequencingidentifiesawidespreadsigma70dependentpausingregulatedbygrefactorsinbacteria
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Nascent RNA sequencing identifies a widespread sigma70-dependent pausing regulated by Gre factors in bacteria

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