Serum Cystatin C in Patients with Delayed Graft Function

Despite recent studies showing that serum Cystatin C (CysC) is a better marker for glomerular filtration rate (GFR) than the ubiquitously used creatinine, the clinical utility of these findings remains to be evaluated. This marker is very sensitive for allograft function after renal transplantation....

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Autores principales:	Boncheva M., Gruev T., Nikolov G.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	renal transplantation delayed graft function cystatin c Medicine R
Acceso en línea:	https://doaj.org/article/a3fe18d0903b4baf989b5cd0e5dc6aef
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spelling	oai:doaj.org-article:a3fe18d0903b4baf989b5cd0e5dc6aef2021-12-02T19:11:12ZSerum Cystatin C in Patients with Delayed Graft Function0324-175010.1515/amb-2016-0002https://doaj.org/article/a3fe18d0903b4baf989b5cd0e5dc6aef2016-03-01T00:00:00Zhttps://doi.org/10.1515/amb-2016-0002https://doaj.org/toc/0324-1750Despite recent studies showing that serum Cystatin C (CysC) is a better marker for glomerular filtration rate (GFR) than the ubiquitously used creatinine, the clinical utility of these findings remains to be evaluated. This marker is very sensitive for allograft function after renal transplantation. The concentration of CysC was compared with that of the creatinine. Decreased renal function was followed in 64 transplanted patients. Serum CysC significantly correlated with creatinine in healthy controls (r = 0.625, p < 0.0001), whereas in the transplanted patients the mean serum creatinine and CysC concentrations were: 81 ± 13 mmol/L and 0.90 ± 0.22 mg/L, respectively. Serum CysC and creatinine significantly correlated throughout the post transplantation period (r = 0.686, p < 0.001), but we confirmed differences between kinetics of these parameters. In the first four days after transplantation the CysC concentration was normalized faster than the creatinine concentration. Development of acute rejection episode (between 5 and 7 days) showed high sensitivity and specificity of the changes of CysC compared with those of creatinine.Boncheva M.Gruev T.Nikolov G.Sciendoarticlerenal transplantationdelayed graft functioncystatin cMedicineRENActa Medica Bulgarica, Vol 43, Iss 1, Pp 14-22 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	renal transplantation delayed graft function cystatin c Medicine R
spellingShingle	renal transplantation delayed graft function cystatin c Medicine R Boncheva M. Gruev T. Nikolov G. Serum Cystatin C in Patients with Delayed Graft Function
description	Despite recent studies showing that serum Cystatin C (CysC) is a better marker for glomerular filtration rate (GFR) than the ubiquitously used creatinine, the clinical utility of these findings remains to be evaluated. This marker is very sensitive for allograft function after renal transplantation. The concentration of CysC was compared with that of the creatinine. Decreased renal function was followed in 64 transplanted patients. Serum CysC significantly correlated with creatinine in healthy controls (r = 0.625, p < 0.0001), whereas in the transplanted patients the mean serum creatinine and CysC concentrations were: 81 ± 13 mmol/L and 0.90 ± 0.22 mg/L, respectively. Serum CysC and creatinine significantly correlated throughout the post transplantation period (r = 0.686, p < 0.001), but we confirmed differences between kinetics of these parameters. In the first four days after transplantation the CysC concentration was normalized faster than the creatinine concentration. Development of acute rejection episode (between 5 and 7 days) showed high sensitivity and specificity of the changes of CysC compared with those of creatinine.
format	article
author	Boncheva M. Gruev T. Nikolov G.
author_facet	Boncheva M. Gruev T. Nikolov G.
author_sort	Boncheva M.
title	Serum Cystatin C in Patients with Delayed Graft Function
title_short	Serum Cystatin C in Patients with Delayed Graft Function
title_full	Serum Cystatin C in Patients with Delayed Graft Function
title_fullStr	Serum Cystatin C in Patients with Delayed Graft Function
title_full_unstemmed	Serum Cystatin C in Patients with Delayed Graft Function
title_sort	serum cystatin c in patients with delayed graft function
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/a3fe18d0903b4baf989b5cd0e5dc6aef
work_keys_str_mv	AT bonchevam serumcystatincinpatientswithdelayedgraftfunction AT gruevt serumcystatincinpatientswithdelayedgraftfunction AT nikolovg serumcystatincinpatientswithdelayedgraftfunction
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Serum Cystatin C in Patients with Delayed Graft Function

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