Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme
Mutations in the chromatin modifier Chd7 have been associated with CHARGE syndrome and other developmental disorders. Here the authors show that Chd7 is required for the activation of genes essential for cerebellar granule cell differentiation, and that disrupting Chd7 leads to cerebellar hypoplasia...
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2017
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oai:doaj.org-article:a402443280f6419d867e3b5b78b484b12021-12-02T15:38:31ZChd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme10.1038/ncomms147582041-1723https://doaj.org/article/a402443280f6419d867e3b5b78b484b12017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14758https://doaj.org/toc/2041-1723Mutations in the chromatin modifier Chd7 have been associated with CHARGE syndrome and other developmental disorders. Here the authors show that Chd7 is required for the activation of genes essential for cerebellar granule cell differentiation, and that disrupting Chd7 leads to cerebellar hypoplasia in mice.Weijun FengDaisuke KawauchiHuiqin Körkel-QuHuan DengElisabeth SergerLaura SieberJenna Ariel LiebermanSilvia Jimeno-GonzálezSander LamboBola S. HannaYassin HarimMalin JansenAnna NeuerburgOlga FriesenMarc ZuckermannVijayanad RajendranJan GronychOlivier AyraultAndrey KorshunovDavid T. W. JonesMarcel KoolPaul A. NorthcottPeter LichterFelipe Cortés-LedesmaStefan M. PfisterHai-Kun LiuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
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| topic |
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Science Q Weijun Feng Daisuke Kawauchi Huiqin Körkel-Qu Huan Deng Elisabeth Serger Laura Sieber Jenna Ariel Lieberman Silvia Jimeno-González Sander Lambo Bola S. Hanna Yassin Harim Malin Jansen Anna Neuerburg Olga Friesen Marc Zuckermann Vijayanad Rajendran Jan Gronych Olivier Ayrault Andrey Korshunov David T. W. Jones Marcel Kool Paul A. Northcott Peter Lichter Felipe Cortés-Ledesma Stefan M. Pfister Hai-Kun Liu Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme |
| description |
Mutations in the chromatin modifier Chd7 have been associated with CHARGE syndrome and other developmental disorders. Here the authors show that Chd7 is required for the activation of genes essential for cerebellar granule cell differentiation, and that disrupting Chd7 leads to cerebellar hypoplasia in mice. |
| format |
article |
| author |
Weijun Feng Daisuke Kawauchi Huiqin Körkel-Qu Huan Deng Elisabeth Serger Laura Sieber Jenna Ariel Lieberman Silvia Jimeno-González Sander Lambo Bola S. Hanna Yassin Harim Malin Jansen Anna Neuerburg Olga Friesen Marc Zuckermann Vijayanad Rajendran Jan Gronych Olivier Ayrault Andrey Korshunov David T. W. Jones Marcel Kool Paul A. Northcott Peter Lichter Felipe Cortés-Ledesma Stefan M. Pfister Hai-Kun Liu |
| author_facet |
Weijun Feng Daisuke Kawauchi Huiqin Körkel-Qu Huan Deng Elisabeth Serger Laura Sieber Jenna Ariel Lieberman Silvia Jimeno-González Sander Lambo Bola S. Hanna Yassin Harim Malin Jansen Anna Neuerburg Olga Friesen Marc Zuckermann Vijayanad Rajendran Jan Gronych Olivier Ayrault Andrey Korshunov David T. W. Jones Marcel Kool Paul A. Northcott Peter Lichter Felipe Cortés-Ledesma Stefan M. Pfister Hai-Kun Liu |
| author_sort |
Weijun Feng |
| title |
Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme |
| title_short |
Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme |
| title_full |
Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme |
| title_fullStr |
Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme |
| title_full_unstemmed |
Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme |
| title_sort |
chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/a402443280f6419d867e3b5b78b484b1 |
| work_keys_str_mv |
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1718386191101853696 |