From oscillatory transcranial current stimulation to scalp EEG changes: a biophysical and physiological modeling study.

Both biophysical and neurophysiological aspects need to be considered to assess the impact of electric fields induced by transcranial current stimulation (tCS) on the cerebral cortex and the subsequent effects occurring on scalp EEG. The objective of this work was to elaborate a global model allowin...

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Autores principales:	Isabelle Merlet, Gwénaël Birot, Ricardo Salvador, Behnam Molaee-Ardekani, Abeye Mekonnen, Aureli Soria-Frish, Giulio Ruffini, Pedro C Miranda, Fabrice Wendling
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a40fc0f5bf844952be1b8f917ac92c42
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spelling	oai:doaj.org-article:a40fc0f5bf844952be1b8f917ac92c422021-11-18T07:55:33ZFrom oscillatory transcranial current stimulation to scalp EEG changes: a biophysical and physiological modeling study.1932-620310.1371/journal.pone.0057330https://doaj.org/article/a40fc0f5bf844952be1b8f917ac92c422013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23468970/?tool=EBIhttps://doaj.org/toc/1932-6203Both biophysical and neurophysiological aspects need to be considered to assess the impact of electric fields induced by transcranial current stimulation (tCS) on the cerebral cortex and the subsequent effects occurring on scalp EEG. The objective of this work was to elaborate a global model allowing for the simulation of scalp EEG signals under tCS. In our integrated modeling approach, realistic meshes of the head tissues and of the stimulation electrodes were first built to map the generated electric field distribution on the cortical surface. Secondly, source activities at various cortical macro-regions were generated by means of a computational model of neuronal populations. The model parameters were adjusted so that populations generated an oscillating activity around 10 Hz resembling typical EEG alpha activity. In order to account for tCS effects and following current biophysical models, the calculated component of the electric field normal to the cortex was used to locally influence the activity of neuronal populations. Lastly, EEG under both spontaneous and tACS-stimulated (transcranial sinunoidal tCS from 4 to 16 Hz) brain activity was simulated at the level of scalp electrodes by solving the forward problem in the aforementioned realistic head model. Under the 10 Hz-tACS condition, a significant increase in alpha power occurred in simulated scalp EEG signals as compared to the no-stimulation condition. This increase involved most channels bilaterally, was more pronounced on posterior electrodes and was only significant for tACS frequencies from 8 to 12 Hz. The immediate effects of tACS in the model agreed with the post-tACS results previously reported in real subjects. Moreover, additional information was also brought by the model at other electrode positions or stimulation frequency. This suggests that our modeling approach can be used to compare, interpret and predict changes occurring on EEG with respect to parameters used in specific stimulation configurations.Isabelle MerletGwénaël BirotRicardo SalvadorBehnam Molaee-ArdekaniAbeye MekonnenAureli Soria-FrishGiulio RuffiniPedro C MirandaFabrice WendlingPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e57330 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Isabelle Merlet Gwénaël Birot Ricardo Salvador Behnam Molaee-Ardekani Abeye Mekonnen Aureli Soria-Frish Giulio Ruffini Pedro C Miranda Fabrice Wendling From oscillatory transcranial current stimulation to scalp EEG changes: a biophysical and physiological modeling study.
description	Both biophysical and neurophysiological aspects need to be considered to assess the impact of electric fields induced by transcranial current stimulation (tCS) on the cerebral cortex and the subsequent effects occurring on scalp EEG. The objective of this work was to elaborate a global model allowing for the simulation of scalp EEG signals under tCS. In our integrated modeling approach, realistic meshes of the head tissues and of the stimulation electrodes were first built to map the generated electric field distribution on the cortical surface. Secondly, source activities at various cortical macro-regions were generated by means of a computational model of neuronal populations. The model parameters were adjusted so that populations generated an oscillating activity around 10 Hz resembling typical EEG alpha activity. In order to account for tCS effects and following current biophysical models, the calculated component of the electric field normal to the cortex was used to locally influence the activity of neuronal populations. Lastly, EEG under both spontaneous and tACS-stimulated (transcranial sinunoidal tCS from 4 to 16 Hz) brain activity was simulated at the level of scalp electrodes by solving the forward problem in the aforementioned realistic head model. Under the 10 Hz-tACS condition, a significant increase in alpha power occurred in simulated scalp EEG signals as compared to the no-stimulation condition. This increase involved most channels bilaterally, was more pronounced on posterior electrodes and was only significant for tACS frequencies from 8 to 12 Hz. The immediate effects of tACS in the model agreed with the post-tACS results previously reported in real subjects. Moreover, additional information was also brought by the model at other electrode positions or stimulation frequency. This suggests that our modeling approach can be used to compare, interpret and predict changes occurring on EEG with respect to parameters used in specific stimulation configurations.
format	article
author	Isabelle Merlet Gwénaël Birot Ricardo Salvador Behnam Molaee-Ardekani Abeye Mekonnen Aureli Soria-Frish Giulio Ruffini Pedro C Miranda Fabrice Wendling
author_facet	Isabelle Merlet Gwénaël Birot Ricardo Salvador Behnam Molaee-Ardekani Abeye Mekonnen Aureli Soria-Frish Giulio Ruffini Pedro C Miranda Fabrice Wendling
author_sort	Isabelle Merlet
title	From oscillatory transcranial current stimulation to scalp EEG changes: a biophysical and physiological modeling study.
title_short	From oscillatory transcranial current stimulation to scalp EEG changes: a biophysical and physiological modeling study.
title_full	From oscillatory transcranial current stimulation to scalp EEG changes: a biophysical and physiological modeling study.
title_fullStr	From oscillatory transcranial current stimulation to scalp EEG changes: a biophysical and physiological modeling study.
title_full_unstemmed	From oscillatory transcranial current stimulation to scalp EEG changes: a biophysical and physiological modeling study.
title_sort	from oscillatory transcranial current stimulation to scalp eeg changes: a biophysical and physiological modeling study.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/a40fc0f5bf844952be1b8f917ac92c42
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From oscillatory transcranial current stimulation to scalp EEG changes: a biophysical and physiological modeling study.

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