No association between BDNFVal66Met polymorphism and treatment response in obsessive-compulsive disorder in the Japanese population

No association between BDNFVal66Met polymorphism and treatment response in obsessive-compulsive disorder in the Japanese population

Hidehiro Umehara,1 Shusuke Numata,1 Makoto Kinoshita,1 Shinya Watanabe,1 Shutaro Nakaaki,2 Satsuki Sumitani,1,3 Tetsuro Ohmori1 1Department of Psychiatry, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 2Laboratory of Aging, Behavior and Cognition, Department of N...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Umehara H, Numata S, Kinoshita M, Watanabe S, Nakaaki S, Sumitani S, Ohmori T
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2016
Materias:
obsessive-compulsive disorder
BDNF
treatment response
association study
SSRI
atypical antipsychotic
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/a4120ecddd35460bba9020c47044558b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:a4120ecddd35460bba9020c47044558b
record_format dspace
spelling oai:doaj.org-article:a4120ecddd35460bba9020c47044558b2021-12-02T04:09:30ZNo association between BDNFVal66Met polymorphism and treatment response in obsessive-compulsive disorder in the Japanese population1178-2021https://doaj.org/article/a4120ecddd35460bba9020c47044558b2016-03-01T00:00:00Zhttps://www.dovepress.com/no-association-between-bdnfval66met-polymorphism-and-treatment-respons-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Hidehiro Umehara,1 Shusuke Numata,1 Makoto Kinoshita,1 Shinya Watanabe,1 Shutaro Nakaaki,2 Satsuki Sumitani,1,3 Tetsuro Ohmori1 1Department of Psychiatry, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 2Laboratory of Aging, Behavior and Cognition, Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, 3Academic Support Office for Students with Special Needs, Tokushima University, Tokushima, Japan Aim: Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family, and it promotes the development and function of dopaminergic and serotonergic neurons. The Met allele of the BDNF Val66Met polymorphism is associated with a decrease in activity-dependent secretion of BDNF compared with the Val allele, and a number of studies have provided evidence for the association between this polymorphism and obsessive-compulsive disorder (OCD). The purpose of this study was to investigate whether this functional variant of the BDNF gene is associated with OCD and treatment response in patients with OCD in the Japanese population.Methods: We first performed a case–control association study between the BDNF Val66Met polymorphism and OCD (175 cases and 2,027 controls). Then, we examined an association between this polymorphism and treatment response in 96 patients with OCD.Results: We found no significant association between the Met allele and OCD risk or between the Met allele and treatment responses to selective serotonin reuptake inhibitors or serotonin reuptake inhibitor with an atypical antipsychotic (P>0.05).Conclusion: Our results suggest that the BDNF Val66Met polymorphism may not be associated as a risk factor for developing OCD or with therapeutic response in patients with OCD in the Japanese population. Keywords: obsessive-compulsive disorder, BDNF, treatment response, association study, SSRI, atypical antipsychoticUmehara HNumata SKinoshita MWatanabe SNakaaki SSumitani SOhmori TDove Medical Pressarticleobsessive-compulsive disorderBDNFtreatment responseassociation studySSRIatypical antipsychoticNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 611-615 (2016)
institution DOAJ
collection DOAJ
language EN
topic obsessive-compulsive disorder
BDNF
treatment response
association study
SSRI
atypical antipsychotic
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle obsessive-compulsive disorder
BDNF
treatment response
association study
SSRI
atypical antipsychotic
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Umehara H
Numata S
Kinoshita M
Watanabe S
Nakaaki S
Sumitani S
Ohmori T
No association between BDNFVal66Met polymorphism and treatment response in obsessive-compulsive disorder in the Japanese population
description Hidehiro Umehara,1 Shusuke Numata,1 Makoto Kinoshita,1 Shinya Watanabe,1 Shutaro Nakaaki,2 Satsuki Sumitani,1,3 Tetsuro Ohmori1 1Department of Psychiatry, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, 2Laboratory of Aging, Behavior and Cognition, Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, 3Academic Support Office for Students with Special Needs, Tokushima University, Tokushima, Japan Aim: Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family, and it promotes the development and function of dopaminergic and serotonergic neurons. The Met allele of the BDNF Val66Met polymorphism is associated with a decrease in activity-dependent secretion of BDNF compared with the Val allele, and a number of studies have provided evidence for the association between this polymorphism and obsessive-compulsive disorder (OCD). The purpose of this study was to investigate whether this functional variant of the BDNF gene is associated with OCD and treatment response in patients with OCD in the Japanese population.Methods: We first performed a case–control association study between the BDNF Val66Met polymorphism and OCD (175 cases and 2,027 controls). Then, we examined an association between this polymorphism and treatment response in 96 patients with OCD.Results: We found no significant association between the Met allele and OCD risk or between the Met allele and treatment responses to selective serotonin reuptake inhibitors or serotonin reuptake inhibitor with an atypical antipsychotic (P>0.05).Conclusion: Our results suggest that the BDNF Val66Met polymorphism may not be associated as a risk factor for developing OCD or with therapeutic response in patients with OCD in the Japanese population. Keywords: obsessive-compulsive disorder, BDNF, treatment response, association study, SSRI, atypical antipsychotic
format article
author Umehara H
Numata S
Kinoshita M
Watanabe S
Nakaaki S
Sumitani S
Ohmori T
author_facet Umehara H
Numata S
Kinoshita M
Watanabe S
Nakaaki S
Sumitani S
Ohmori T
author_sort Umehara H
title No association between BDNFVal66Met polymorphism and treatment response in obsessive-compulsive disorder in the Japanese population
title_short No association between BDNFVal66Met polymorphism and treatment response in obsessive-compulsive disorder in the Japanese population
title_full No association between BDNFVal66Met polymorphism and treatment response in obsessive-compulsive disorder in the Japanese population
title_fullStr No association between BDNFVal66Met polymorphism and treatment response in obsessive-compulsive disorder in the Japanese population
title_full_unstemmed No association between BDNFVal66Met polymorphism and treatment response in obsessive-compulsive disorder in the Japanese population
title_sort no association between bdnfval66met polymorphism and treatment response in obsessive-compulsive disorder in the japanese population
publisher Dove Medical Press
publishDate 2016
url https://doaj.org/article/a4120ecddd35460bba9020c47044558b
work_keys_str_mv AT umeharah noassociationbetweenbdnfval66metpolymorphismandtreatmentresponseinobsessivecompulsivedisorderinthejapanesenbsppopulation
AT numatas noassociationbetweenbdnfval66metpolymorphismandtreatmentresponseinobsessivecompulsivedisorderinthejapanesenbsppopulation
AT kinoshitam noassociationbetweenbdnfval66metpolymorphismandtreatmentresponseinobsessivecompulsivedisorderinthejapanesenbsppopulation
AT watanabes noassociationbetweenbdnfval66metpolymorphismandtreatmentresponseinobsessivecompulsivedisorderinthejapanesenbsppopulation
AT nakaakis noassociationbetweenbdnfval66metpolymorphismandtreatmentresponseinobsessivecompulsivedisorderinthejapanesenbsppopulation
AT sumitanis noassociationbetweenbdnfval66metpolymorphismandtreatmentresponseinobsessivecompulsivedisorderinthejapanesenbsppopulation
AT ohmorit noassociationbetweenbdnfval66metpolymorphismandtreatmentresponseinobsessivecompulsivedisorderinthejapanesenbsppopulation
_version_ 1718401449493266432

Ejemplares similares