Relation of Prenatal Air Pollutant and Nutritional Exposures with Biomarkers of Allergic Disease in Adolescence

Abstract Prenatal exposures may be critical for immune system development, with consequences for allergic disease susceptibility. We examined associations of prenatal exposures (nutrient intakes and air pollutants) with allergic disease biomarkers in adolescence. We used data from 857 mother-child p...

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Autores principales:	Joanne E. Sordillo, Karen M. Switkowski, Brent A. Coull, Joel Schwartz, Itai Kloog, Heike Gibson, Augusto A. Litonjua, Jennifer Bobb, Petros Koutrakis, Sheryl L. Rifas-Shiman, Emily Oken, Diane R. Gold
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a4172cd2fd1b42678353581c5f1dd19e
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spelling	oai:doaj.org-article:a4172cd2fd1b42678353581c5f1dd19e2021-12-02T15:07:59ZRelation of Prenatal Air Pollutant and Nutritional Exposures with Biomarkers of Allergic Disease in Adolescence10.1038/s41598-018-28216-02045-2322https://doaj.org/article/a4172cd2fd1b42678353581c5f1dd19e2018-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-28216-0https://doaj.org/toc/2045-2322Abstract Prenatal exposures may be critical for immune system development, with consequences for allergic disease susceptibility. We examined associations of prenatal exposures (nutrient intakes and air pollutants) with allergic disease biomarkers in adolescence. We used data from 857 mother-child pairs in Project Viva, a Massachusetts-based pre-birth cohort. Outcomes of interest at follow-up (median age 12.9 years) were fractional exhaled nitric oxide (FeNO) and total serum IgE. We applied Bayesian Kernel Machine Regression analyses to estimate multivariate exposure-response functions, allowing for exposure interactions. Exposures were expressed as z-scores of log-transformed data and we report effects in % change in FeNO or IgE z-score per increase in exposure from the 25th to 75th percentile. FeNO levels were lower with higher intakes of prenatal vitamin D (−16.15%, 95% CI: −20.38 to −2.88%), folate from foods (−3.86%, 95% CI: −8.33 to 0.83%) and n-3 PUFAs (−9.21%, 95% CI −16.81 to −0.92%). Prenatal air pollutants were associated with higher FeNO and IgE, with the strongest associations detected for PM2.5 with IgE (25.6% increase, 95% CI 9.34% to 44.29%). We identified a potential synergistic interaction (p = 0.02) between vitamin E (food + supplements) and PM2.5; this exposure combination was associated with further increases in FeNO levels.Joanne E. SordilloKaren M. SwitkowskiBrent A. CoullJoel SchwartzItai KloogHeike GibsonAugusto A. LitonjuaJennifer BobbPetros KoutrakisSheryl L. Rifas-ShimanEmily OkenDiane R. GoldNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joanne E. Sordillo Karen M. Switkowski Brent A. Coull Joel Schwartz Itai Kloog Heike Gibson Augusto A. Litonjua Jennifer Bobb Petros Koutrakis Sheryl L. Rifas-Shiman Emily Oken Diane R. Gold Relation of Prenatal Air Pollutant and Nutritional Exposures with Biomarkers of Allergic Disease in Adolescence
description	Abstract Prenatal exposures may be critical for immune system development, with consequences for allergic disease susceptibility. We examined associations of prenatal exposures (nutrient intakes and air pollutants) with allergic disease biomarkers in adolescence. We used data from 857 mother-child pairs in Project Viva, a Massachusetts-based pre-birth cohort. Outcomes of interest at follow-up (median age 12.9 years) were fractional exhaled nitric oxide (FeNO) and total serum IgE. We applied Bayesian Kernel Machine Regression analyses to estimate multivariate exposure-response functions, allowing for exposure interactions. Exposures were expressed as z-scores of log-transformed data and we report effects in % change in FeNO or IgE z-score per increase in exposure from the 25th to 75th percentile. FeNO levels were lower with higher intakes of prenatal vitamin D (−16.15%, 95% CI: −20.38 to −2.88%), folate from foods (−3.86%, 95% CI: −8.33 to 0.83%) and n-3 PUFAs (−9.21%, 95% CI −16.81 to −0.92%). Prenatal air pollutants were associated with higher FeNO and IgE, with the strongest associations detected for PM2.5 with IgE (25.6% increase, 95% CI 9.34% to 44.29%). We identified a potential synergistic interaction (p = 0.02) between vitamin E (food + supplements) and PM2.5; this exposure combination was associated with further increases in FeNO levels.
format	article
author	Joanne E. Sordillo Karen M. Switkowski Brent A. Coull Joel Schwartz Itai Kloog Heike Gibson Augusto A. Litonjua Jennifer Bobb Petros Koutrakis Sheryl L. Rifas-Shiman Emily Oken Diane R. Gold
author_facet	Joanne E. Sordillo Karen M. Switkowski Brent A. Coull Joel Schwartz Itai Kloog Heike Gibson Augusto A. Litonjua Jennifer Bobb Petros Koutrakis Sheryl L. Rifas-Shiman Emily Oken Diane R. Gold
author_sort	Joanne E. Sordillo
title	Relation of Prenatal Air Pollutant and Nutritional Exposures with Biomarkers of Allergic Disease in Adolescence
title_short	Relation of Prenatal Air Pollutant and Nutritional Exposures with Biomarkers of Allergic Disease in Adolescence
title_full	Relation of Prenatal Air Pollutant and Nutritional Exposures with Biomarkers of Allergic Disease in Adolescence
title_fullStr	Relation of Prenatal Air Pollutant and Nutritional Exposures with Biomarkers of Allergic Disease in Adolescence
title_full_unstemmed	Relation of Prenatal Air Pollutant and Nutritional Exposures with Biomarkers of Allergic Disease in Adolescence
title_sort	relation of prenatal air pollutant and nutritional exposures with biomarkers of allergic disease in adolescence
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a4172cd2fd1b42678353581c5f1dd19e
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Relation of Prenatal Air Pollutant and Nutritional Exposures with Biomarkers of Allergic Disease in Adolescence

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