The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis

Yap is a transcriptional factor involved in tumorigenesis. Here the authors show that a previously unknown post-translational modification of Yap, O-GlcNAcylation, increases its transcriptional activity and is required for high glucose-induced liver cancer development.

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Autores principales:	Xiao Zhang, Yongxia Qiao, Qi Wu, Yan Chen, Shaowu Zou, Xiangfan Liu, Guoqing Zhu, Yinghui Zhao, Yuxin Chen, Yongchun Yu, Qiuhui Pan, Jiayi Wang, Fenyong Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a41aed7f74b947d7ae8619b5e9637eb2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:a41aed7f74b947d7ae8619b5e9637eb22021-12-02T14:40:34ZThe essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis10.1038/ncomms152802041-1723https://doaj.org/article/a41aed7f74b947d7ae8619b5e9637eb22017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15280https://doaj.org/toc/2041-1723Yap is a transcriptional factor involved in tumorigenesis. Here the authors show that a previously unknown post-translational modification of Yap, O-GlcNAcylation, increases its transcriptional activity and is required for high glucose-induced liver cancer development.Xiao ZhangYongxia QiaoQi WuYan ChenShaowu ZouXiangfan LiuGuoqing ZhuYinghui ZhaoYuxin ChenYongchun YuQiuhui PanJiayi WangFenyong SunNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiao Zhang Yongxia Qiao Qi Wu Yan Chen Shaowu Zou Xiangfan Liu Guoqing Zhu Yinghui Zhao Yuxin Chen Yongchun Yu Qiuhui Pan Jiayi Wang Fenyong Sun The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis
description	Yap is a transcriptional factor involved in tumorigenesis. Here the authors show that a previously unknown post-translational modification of Yap, O-GlcNAcylation, increases its transcriptional activity and is required for high glucose-induced liver cancer development.
format	article
author	Xiao Zhang Yongxia Qiao Qi Wu Yan Chen Shaowu Zou Xiangfan Liu Guoqing Zhu Yinghui Zhao Yuxin Chen Yongchun Yu Qiuhui Pan Jiayi Wang Fenyong Sun
author_facet	Xiao Zhang Yongxia Qiao Qi Wu Yan Chen Shaowu Zou Xiangfan Liu Guoqing Zhu Yinghui Zhao Yuxin Chen Yongchun Yu Qiuhui Pan Jiayi Wang Fenyong Sun
author_sort	Xiao Zhang
title	The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis
title_short	The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis
title_full	The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis
title_fullStr	The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis
title_full_unstemmed	The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis
title_sort	essential role of yap o-glcnacylation in high-glucose-stimulated liver tumorigenesis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/a41aed7f74b947d7ae8619b5e9637eb2
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The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis

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