The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis

The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis

Yap is a transcriptional factor involved in tumorigenesis. Here the authors show that a previously unknown post-translational modification of Yap, O-GlcNAcylation, increases its transcriptional activity and is required for high glucose-induced liver cancer development.

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Detalles Bibliográficos
Autores principales: Xiao Zhang, Yongxia Qiao, Qi Wu, Yan Chen, Shaowu Zou, Xiangfan Liu, Guoqing Zhu, Yinghui Zhao, Yuxin Chen, Yongchun Yu, Qiuhui Pan, Jiayi Wang, Fenyong Sun
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/a41aed7f74b947d7ae8619b5e9637eb2
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