Performance of a cardiac lipid panel compared to four prognostic scores in chronic heart failure

Abstract The cardiac lipid panel (CLP) is a novel panel of metabolomic biomarkers that has previously shown to improve the diagnostic and prognostic value for CHF patients. Several prognostic scores have been developed for cardiovascular disease risk, but their use is limited to specific populations...

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Autores principales:	Peter McGranaghan, Anshul Saxena, Hans-Dirk Düngen, Muni Rubens, Sandeep Appunni, Joseph Salami, Emir Veledar, Philipp Lacour, Florian Blaschke, Danilo Obradovic, Goran Loncar, Elvis Tahirovic, Frank Edelmann, Burkert Pieske, Tobias Daniel Trippel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a41b0e9c9ddb425f95deab8acb9aae5f
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spelling	oai:doaj.org-article:a41b0e9c9ddb425f95deab8acb9aae5f2021-12-02T14:26:20ZPerformance of a cardiac lipid panel compared to four prognostic scores in chronic heart failure10.1038/s41598-021-87776-w2045-2322https://doaj.org/article/a41b0e9c9ddb425f95deab8acb9aae5f2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87776-whttps://doaj.org/toc/2045-2322Abstract The cardiac lipid panel (CLP) is a novel panel of metabolomic biomarkers that has previously shown to improve the diagnostic and prognostic value for CHF patients. Several prognostic scores have been developed for cardiovascular disease risk, but their use is limited to specific populations and precision is still inadequate. We compared a risk score using the CLP plus NT-proBNP to four commonly used risk scores: The Seattle Heart Failure Model (SHFM), Framingham risk score (FRS), Barcelona bio-HF (BCN Bio-HF) and Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) score. We included 280 elderly CHF patients from the Cardiac Insufficiency Bisoprolol Study in Elderly trial. Cox Regression and hierarchical cluster analysis was performed. Integrated area under the curves (IAUC) was used as criterium for comparison. The mean (SD) follow-up period was 81 (33) months, and 95 (34%) subjects met the primary endpoint. The IAUC for FRS was 0.53, SHFM 0.61, BCN Bio-HF 0.72, MAGGIC 0.68, and CLP 0.78. Subjects were partitioned into three risk clusters: low, moderate, high with the CLP score showing the best ability to group patients into their respective risk cluster. A risk score composed of a novel panel of metabolite biomarkers plus NT-proBNP outperformed other common prognostic scores in predicting 10-year cardiovascular death in elderly ambulatory CHF patients. This approach could improve the clinical risk assessment of CHF patients.Peter McGranaghanAnshul SaxenaHans-Dirk DüngenMuni RubensSandeep AppunniJoseph SalamiEmir VeledarPhilipp LacourFlorian BlaschkeDanilo ObradovicGoran LoncarElvis TahirovicFrank EdelmannBurkert PieskeTobias Daniel TrippelNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Peter McGranaghan Anshul Saxena Hans-Dirk Düngen Muni Rubens Sandeep Appunni Joseph Salami Emir Veledar Philipp Lacour Florian Blaschke Danilo Obradovic Goran Loncar Elvis Tahirovic Frank Edelmann Burkert Pieske Tobias Daniel Trippel Performance of a cardiac lipid panel compared to four prognostic scores in chronic heart failure
description	Abstract The cardiac lipid panel (CLP) is a novel panel of metabolomic biomarkers that has previously shown to improve the diagnostic and prognostic value for CHF patients. Several prognostic scores have been developed for cardiovascular disease risk, but their use is limited to specific populations and precision is still inadequate. We compared a risk score using the CLP plus NT-proBNP to four commonly used risk scores: The Seattle Heart Failure Model (SHFM), Framingham risk score (FRS), Barcelona bio-HF (BCN Bio-HF) and Meta-Analysis Global Group in Chronic Heart Failure (MAGGIC) score. We included 280 elderly CHF patients from the Cardiac Insufficiency Bisoprolol Study in Elderly trial. Cox Regression and hierarchical cluster analysis was performed. Integrated area under the curves (IAUC) was used as criterium for comparison. The mean (SD) follow-up period was 81 (33) months, and 95 (34%) subjects met the primary endpoint. The IAUC for FRS was 0.53, SHFM 0.61, BCN Bio-HF 0.72, MAGGIC 0.68, and CLP 0.78. Subjects were partitioned into three risk clusters: low, moderate, high with the CLP score showing the best ability to group patients into their respective risk cluster. A risk score composed of a novel panel of metabolite biomarkers plus NT-proBNP outperformed other common prognostic scores in predicting 10-year cardiovascular death in elderly ambulatory CHF patients. This approach could improve the clinical risk assessment of CHF patients.
format	article
author	Peter McGranaghan Anshul Saxena Hans-Dirk Düngen Muni Rubens Sandeep Appunni Joseph Salami Emir Veledar Philipp Lacour Florian Blaschke Danilo Obradovic Goran Loncar Elvis Tahirovic Frank Edelmann Burkert Pieske Tobias Daniel Trippel
author_facet	Peter McGranaghan Anshul Saxena Hans-Dirk Düngen Muni Rubens Sandeep Appunni Joseph Salami Emir Veledar Philipp Lacour Florian Blaschke Danilo Obradovic Goran Loncar Elvis Tahirovic Frank Edelmann Burkert Pieske Tobias Daniel Trippel
author_sort	Peter McGranaghan
title	Performance of a cardiac lipid panel compared to four prognostic scores in chronic heart failure
title_short	Performance of a cardiac lipid panel compared to four prognostic scores in chronic heart failure
title_full	Performance of a cardiac lipid panel compared to four prognostic scores in chronic heart failure
title_fullStr	Performance of a cardiac lipid panel compared to four prognostic scores in chronic heart failure
title_full_unstemmed	Performance of a cardiac lipid panel compared to four prognostic scores in chronic heart failure
title_sort	performance of a cardiac lipid panel compared to four prognostic scores in chronic heart failure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a41b0e9c9ddb425f95deab8acb9aae5f
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Performance of a cardiac lipid panel compared to four prognostic scores in chronic heart failure

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