Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits

Brain structural traits are highly heritable and have been linked to disease. Here the authors have used gene expression data to perform a transcriptome-wide association study on 211 brain structural traits, discovering 273 associated genes.

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Autores principales:	Bingxin Zhao, Yue Shan, Yue Yang, Zhaolong Yu, Tengfei Li, Xifeng Wang, Tianyou Luo, Ziliang Zhu, Patrick Sullivan, Hongyu Zhao, Yun Li, Hongtu Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a41c53e39c6b4004b0b33daeee32b305
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spelling	oai:doaj.org-article:a41c53e39c6b4004b0b33daeee32b3052021-12-02T15:52:23ZTranscriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits10.1038/s41467-021-23130-y2041-1723https://doaj.org/article/a41c53e39c6b4004b0b33daeee32b3052021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23130-yhttps://doaj.org/toc/2041-1723Brain structural traits are highly heritable and have been linked to disease. Here the authors have used gene expression data to perform a transcriptome-wide association study on 211 brain structural traits, discovering 273 associated genes.Bingxin ZhaoYue ShanYue YangZhaolong YuTengfei LiXifeng WangTianyou LuoZiliang ZhuPatrick SullivanHongyu ZhaoYun LiHongtu ZhuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bingxin Zhao Yue Shan Yue Yang Zhaolong Yu Tengfei Li Xifeng Wang Tianyou Luo Ziliang Zhu Patrick Sullivan Hongyu Zhao Yun Li Hongtu Zhu Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits
description	Brain structural traits are highly heritable and have been linked to disease. Here the authors have used gene expression data to perform a transcriptome-wide association study on 211 brain structural traits, discovering 273 associated genes.
format	article
author	Bingxin Zhao Yue Shan Yue Yang Zhaolong Yu Tengfei Li Xifeng Wang Tianyou Luo Ziliang Zhu Patrick Sullivan Hongyu Zhao Yun Li Hongtu Zhu
author_facet	Bingxin Zhao Yue Shan Yue Yang Zhaolong Yu Tengfei Li Xifeng Wang Tianyou Luo Ziliang Zhu Patrick Sullivan Hongyu Zhao Yun Li Hongtu Zhu
author_sort	Bingxin Zhao
title	Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits
title_short	Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits
title_full	Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits
title_fullStr	Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits
title_full_unstemmed	Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits
title_sort	transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a41c53e39c6b4004b0b33daeee32b305
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Transcriptome-wide association analysis of brain structures yields insights into pleiotropy with complex neuropsychiatric traits

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