GROWTH HORMONE LEVELS AT INDUCED HYPOGLYCEMIA; AN EFFECTIVE WAY OF DIAGNOSING GROWTH HORMONE DEFICIENCY

Objective: To introduce a relatively convenient and effective way of conducting Insulin Tolerance Test for diagnosis of Growth Hormone deficiency in children with short stature. Study Design: Cross sectional analytical study. Place and Duration of Study: Conducted at Department of Chemical Pat...

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Autores principales:	Nida Basharat, Asif Ali Memon, Sumbal Nida, Naveed Asif, Saima Shakil Malik, Muhammad Tahir Khadim
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2021
Materias:	growth hormone deficiency induced hypoglycemia insulin tolerance test serum growth hormone short stature Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a41d6e8a1b4f4de4a04933bda0b345ee
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spelling	oai:doaj.org-article:a41d6e8a1b4f4de4a04933bda0b345ee2021-12-02T18:44:46ZGROWTH HORMONE LEVELS AT INDUCED HYPOGLYCEMIA; AN EFFECTIVE WAY OF DIAGNOSING GROWTH HORMONE DEFICIENCY0030-96482411-884210.51253/pafmj.v71i1.2467https://doaj.org/article/a41d6e8a1b4f4de4a04933bda0b345ee2021-02-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/2467https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To introduce a relatively convenient and effective way of conducting Insulin Tolerance Test for diagnosis of Growth Hormone deficiency in children with short stature. Study Design: Cross sectional analytical study. Place and Duration of Study: Conducted at Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi, from May 2017 to Jul 2018. Methodology: A total of 185 cases were included. Sample selection was done by non-probability consecutive sampling technique. Insulin tolerance test was performed by taking basal sample for serum growth hormone and plasma glucose levels before giving intravenous insulin bolus according to dose of 0.15 IU/kg. Samples for Growth Hormone level were repeated at time of induced hypoglycemia (defined as plasma glucose level of <2.8 mmol/L), 30 minutes and 60 minutes post induction. Results: Mean age of the patients was 10 ± 4 years, majority 120 (65%) were males. In the study population, 41 (22%) patients showed adequate response to insulin tolerance test while 144 (78%) showed inadequate response. At level of induction, mean growth hormone levels were 31.9 ± 18.8 mIU/l and 4.7 ± 4.4 mIU/l in patients showing adequate and inadequate response respectively (p-value <0.05). Majority 32 (78%) of the patients showing adequate response had peak growth hormone response (>20 mIU/l) at induction alone, followed by 30 minutes post induction; reflecting the significance of these two samples in diagnosis of growth hormone deficiency. Conclusion: We concluded that there is a simpler ...........Nida BasharatAsif Ali MemonSumbal NidaNaveed AsifSaima Shakil MalikMuhammad Tahir KhadimArmy Medical College Rawalpindiarticlegrowth hormone deficiencyinduced hypoglycemiainsulin tolerance testserum growth hormoneshort statureMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 71, Iss 1, Pp 184-89 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	growth hormone deficiency induced hypoglycemia insulin tolerance test serum growth hormone short stature Medicine R Medicine (General) R5-920
spellingShingle	growth hormone deficiency induced hypoglycemia insulin tolerance test serum growth hormone short stature Medicine R Medicine (General) R5-920 Nida Basharat Asif Ali Memon Sumbal Nida Naveed Asif Saima Shakil Malik Muhammad Tahir Khadim GROWTH HORMONE LEVELS AT INDUCED HYPOGLYCEMIA; AN EFFECTIVE WAY OF DIAGNOSING GROWTH HORMONE DEFICIENCY
description	Objective: To introduce a relatively convenient and effective way of conducting Insulin Tolerance Test for diagnosis of Growth Hormone deficiency in children with short stature. Study Design: Cross sectional analytical study. Place and Duration of Study: Conducted at Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, Rawalpindi, from May 2017 to Jul 2018. Methodology: A total of 185 cases were included. Sample selection was done by non-probability consecutive sampling technique. Insulin tolerance test was performed by taking basal sample for serum growth hormone and plasma glucose levels before giving intravenous insulin bolus according to dose of 0.15 IU/kg. Samples for Growth Hormone level were repeated at time of induced hypoglycemia (defined as plasma glucose level of <2.8 mmol/L), 30 minutes and 60 minutes post induction. Results: Mean age of the patients was 10 ± 4 years, majority 120 (65%) were males. In the study population, 41 (22%) patients showed adequate response to insulin tolerance test while 144 (78%) showed inadequate response. At level of induction, mean growth hormone levels were 31.9 ± 18.8 mIU/l and 4.7 ± 4.4 mIU/l in patients showing adequate and inadequate response respectively (p-value <0.05). Majority 32 (78%) of the patients showing adequate response had peak growth hormone response (>20 mIU/l) at induction alone, followed by 30 minutes post induction; reflecting the significance of these two samples in diagnosis of growth hormone deficiency. Conclusion: We concluded that there is a simpler ...........
format	article
author	Nida Basharat Asif Ali Memon Sumbal Nida Naveed Asif Saima Shakil Malik Muhammad Tahir Khadim
author_facet	Nida Basharat Asif Ali Memon Sumbal Nida Naveed Asif Saima Shakil Malik Muhammad Tahir Khadim
author_sort	Nida Basharat
title	GROWTH HORMONE LEVELS AT INDUCED HYPOGLYCEMIA; AN EFFECTIVE WAY OF DIAGNOSING GROWTH HORMONE DEFICIENCY
title_short	GROWTH HORMONE LEVELS AT INDUCED HYPOGLYCEMIA; AN EFFECTIVE WAY OF DIAGNOSING GROWTH HORMONE DEFICIENCY
title_full	GROWTH HORMONE LEVELS AT INDUCED HYPOGLYCEMIA; AN EFFECTIVE WAY OF DIAGNOSING GROWTH HORMONE DEFICIENCY
title_fullStr	GROWTH HORMONE LEVELS AT INDUCED HYPOGLYCEMIA; AN EFFECTIVE WAY OF DIAGNOSING GROWTH HORMONE DEFICIENCY
title_full_unstemmed	GROWTH HORMONE LEVELS AT INDUCED HYPOGLYCEMIA; AN EFFECTIVE WAY OF DIAGNOSING GROWTH HORMONE DEFICIENCY
title_sort	growth hormone levels at induced hypoglycemia; an effective way of diagnosing growth hormone deficiency
publisher	Army Medical College Rawalpindi
publishDate	2021
url	https://doaj.org/article/a41d6e8a1b4f4de4a04933bda0b345ee
work_keys_str_mv	AT nidabasharat growthhormonelevelsatinducedhypoglycemiaaneffectivewayofdiagnosinggrowthhormonedeficiency AT asifalimemon growthhormonelevelsatinducedhypoglycemiaaneffectivewayofdiagnosinggrowthhormonedeficiency AT sumbalnida growthhormonelevelsatinducedhypoglycemiaaneffectivewayofdiagnosinggrowthhormonedeficiency AT naveedasif growthhormonelevelsatinducedhypoglycemiaaneffectivewayofdiagnosinggrowthhormonedeficiency AT saimashakilmalik growthhormonelevelsatinducedhypoglycemiaaneffectivewayofdiagnosinggrowthhormonedeficiency AT muhammadtahirkhadim growthhormonelevelsatinducedhypoglycemiaaneffectivewayofdiagnosinggrowthhormonedeficiency
_version_	1718377696566706176

GROWTH HORMONE LEVELS AT INDUCED HYPOGLYCEMIA; AN EFFECTIVE WAY OF DIAGNOSING GROWTH HORMONE DEFICIENCY

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