Homocysteine and the Risk of Cardiovascular Events and All-Cause Death in Elderly Population: A Community-Based Prospective Cohort Study

Zhongying Zhang,1 Xiang Gu,2 Xianghua Fang,3 Zhe Tang,4 Shaochen Guan,3 Hongjun Liu,3 Xiaoguang Wu,3 Chunxiu Wang,3 Yan Zhao5 1Geriatric Department, Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Medical Affair Department,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhang Z, Gu X, Fang X, Tang Z, Guan S, Liu H, Wu X, Wang C, Zhao Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	homocysteine cardiovascular disease all-cause death prospective cohort study Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/a41e9650ff5e4236a522e660ec14d712
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a41e9650ff5e4236a522e660ec14d712
record_format	dspace
spelling	oai:doaj.org-article:a41e9650ff5e4236a522e660ec14d7122021-12-02T12:06:56ZHomocysteine and the Risk of Cardiovascular Events and All-Cause Death in Elderly Population: A Community-Based Prospective Cohort Study1178-203Xhttps://doaj.org/article/a41e9650ff5e4236a522e660ec14d7122020-05-01T00:00:00Zhttps://www.dovepress.com/homocysteine-and-the-risk-of-cardiovascular-events-and-all-cause-death-peer-reviewed-article-TCRMhttps://doaj.org/toc/1178-203XZhongying Zhang,1 Xiang Gu,2 Xianghua Fang,3 Zhe Tang,4 Shaochen Guan,3 Hongjun Liu,3 Xiaoguang Wu,3 Chunxiu Wang,3 Yan Zhao5 1Geriatric Department, Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Medical Affair Department, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 4Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 5Education Department, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Xianghua FangEvidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Beijing 100053, People’s Republic of ChinaTel/Fax +86-010-63153439Email fangxh_2015@126.comBackground: The association between homocysteine and cardiovascular diseases (CVD) and all-cause death was inconclusive. A community-based prospective cohort study was carried out in Beijing to evaluate this association in elderly population for more effective clinical prediction and primary prevention of CVD.Patients and Methods: Participants were randomly selected from Beijing, China. Questionnaire survey, physical examinations, and laboratory tests were carried out to collect baseline information and investigate clinical characteristics. Each participant was predetermined to be followed by 5 years. CVD events and death were collected as primary variables. A Cox regression analysis was performed to assess the risk of CVD events, CVD death, and all-cause death contributed by homocysteine as well as some other risk factors.Results: A total of 1257 participants with an average age of 69.16 years were enrolled in this study. After adjusting for confounders, the hazard ratios (HRs) and 95% confidence intervals of CVD event, CVD death, and all-cause death caused by intermediate-to-severe hyperhomocysteinemia as compared with normal homocysteine levels were 1.68 (95% CI 1.06– 2.67), 1.97 (95% CI 0.95– 4.29) and 2.02 (95% CI 1.26– 3.24), respectively. Intermediate-to-severe hyperhomocysteinemia increased the risks of CVD event (HR 2.07, 95% CI 1.01– 4.26) and all-cause death (HR 3.08, 95% CI 1.56– 6.07) among male participants. However, the positive association was not statistically significant among female participants (HR 1.59, 95% CI 0.83– 3.04 for CVD event and HR 0.90, 95% CI 0.52– 6.07 for all-cause death). Every 5μmol/L increment in homocysteine concentration was shown to be associated with a 4% (HR 1.04, 95% CI 1.01– 1.07) and 5% (HR 1.05, 95% CI 1.01– 1.07) higher risk of CVD events and all-cause death in all participants. There was no significant association between moderate hyperhomocysteinemia and the risk of the CVD events and all-cause death.Conclusion: Intermediate-to-severe hyperhomocysteinemia was significantly associated with CVD events and all-cause death in elderly population without a history of ischemia or congestive heart failure (CHF). The positive association was pronounced among males.Keywords: homocysteine, cardiovascular disease, all-cause death, prospective cohort studyZhang ZGu XFang XTang ZGuan SLiu HWu XWang CZhao YDove Medical Pressarticlehomocysteinecardiovascular diseaseall-cause deathprospective cohort studyTherapeutics. PharmacologyRM1-950ENTherapeutics and Clinical Risk Management, Vol Volume 16, Pp 471-481 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	homocysteine cardiovascular disease all-cause death prospective cohort study Therapeutics. Pharmacology RM1-950
spellingShingle	homocysteine cardiovascular disease all-cause death prospective cohort study Therapeutics. Pharmacology RM1-950 Zhang Z Gu X Fang X Tang Z Guan S Liu H Wu X Wang C Zhao Y Homocysteine and the Risk of Cardiovascular Events and All-Cause Death in Elderly Population: A Community-Based Prospective Cohort Study
description	Zhongying Zhang,1 Xiang Gu,2 Xianghua Fang,3 Zhe Tang,4 Shaochen Guan,3 Hongjun Liu,3 Xiaoguang Wu,3 Chunxiu Wang,3 Yan Zhao5 1Geriatric Department, Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Medical Affair Department, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 4Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 5Education Department, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of ChinaCorrespondence: Xianghua FangEvidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Beijing 100053, People’s Republic of ChinaTel/Fax +86-010-63153439Email fangxh_2015@126.comBackground: The association between homocysteine and cardiovascular diseases (CVD) and all-cause death was inconclusive. A community-based prospective cohort study was carried out in Beijing to evaluate this association in elderly population for more effective clinical prediction and primary prevention of CVD.Patients and Methods: Participants were randomly selected from Beijing, China. Questionnaire survey, physical examinations, and laboratory tests were carried out to collect baseline information and investigate clinical characteristics. Each participant was predetermined to be followed by 5 years. CVD events and death were collected as primary variables. A Cox regression analysis was performed to assess the risk of CVD events, CVD death, and all-cause death contributed by homocysteine as well as some other risk factors.Results: A total of 1257 participants with an average age of 69.16 years were enrolled in this study. After adjusting for confounders, the hazard ratios (HRs) and 95% confidence intervals of CVD event, CVD death, and all-cause death caused by intermediate-to-severe hyperhomocysteinemia as compared with normal homocysteine levels were 1.68 (95% CI 1.06– 2.67), 1.97 (95% CI 0.95– 4.29) and 2.02 (95% CI 1.26– 3.24), respectively. Intermediate-to-severe hyperhomocysteinemia increased the risks of CVD event (HR 2.07, 95% CI 1.01– 4.26) and all-cause death (HR 3.08, 95% CI 1.56– 6.07) among male participants. However, the positive association was not statistically significant among female participants (HR 1.59, 95% CI 0.83– 3.04 for CVD event and HR 0.90, 95% CI 0.52– 6.07 for all-cause death). Every 5μmol/L increment in homocysteine concentration was shown to be associated with a 4% (HR 1.04, 95% CI 1.01– 1.07) and 5% (HR 1.05, 95% CI 1.01– 1.07) higher risk of CVD events and all-cause death in all participants. There was no significant association between moderate hyperhomocysteinemia and the risk of the CVD events and all-cause death.Conclusion: Intermediate-to-severe hyperhomocysteinemia was significantly associated with CVD events and all-cause death in elderly population without a history of ischemia or congestive heart failure (CHF). The positive association was pronounced among males.Keywords: homocysteine, cardiovascular disease, all-cause death, prospective cohort study
format	article
author	Zhang Z Gu X Fang X Tang Z Guan S Liu H Wu X Wang C Zhao Y
author_facet	Zhang Z Gu X Fang X Tang Z Guan S Liu H Wu X Wang C Zhao Y
author_sort	Zhang Z
title	Homocysteine and the Risk of Cardiovascular Events and All-Cause Death in Elderly Population: A Community-Based Prospective Cohort Study
title_short	Homocysteine and the Risk of Cardiovascular Events and All-Cause Death in Elderly Population: A Community-Based Prospective Cohort Study
title_full	Homocysteine and the Risk of Cardiovascular Events and All-Cause Death in Elderly Population: A Community-Based Prospective Cohort Study
title_fullStr	Homocysteine and the Risk of Cardiovascular Events and All-Cause Death in Elderly Population: A Community-Based Prospective Cohort Study
title_full_unstemmed	Homocysteine and the Risk of Cardiovascular Events and All-Cause Death in Elderly Population: A Community-Based Prospective Cohort Study
title_sort	homocysteine and the risk of cardiovascular events and all-cause death in elderly population: a community-based prospective cohort study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/a41e9650ff5e4236a522e660ec14d712
work_keys_str_mv	AT zhangz homocysteineandtheriskofcardiovasculareventsandallcausedeathinelderlypopulationacommunitybasedprospectivecohortstudy AT gux homocysteineandtheriskofcardiovasculareventsandallcausedeathinelderlypopulationacommunitybasedprospectivecohortstudy AT fangx homocysteineandtheriskofcardiovasculareventsandallcausedeathinelderlypopulationacommunitybasedprospectivecohortstudy AT tangz homocysteineandtheriskofcardiovasculareventsandallcausedeathinelderlypopulationacommunitybasedprospectivecohortstudy AT guans homocysteineandtheriskofcardiovasculareventsandallcausedeathinelderlypopulationacommunitybasedprospectivecohortstudy AT liuh homocysteineandtheriskofcardiovasculareventsandallcausedeathinelderlypopulationacommunitybasedprospectivecohortstudy AT wux homocysteineandtheriskofcardiovasculareventsandallcausedeathinelderlypopulationacommunitybasedprospectivecohortstudy AT wangc homocysteineandtheriskofcardiovasculareventsandallcausedeathinelderlypopulationacommunitybasedprospectivecohortstudy AT zhaoy homocysteineandtheriskofcardiovasculareventsandallcausedeathinelderlypopulationacommunitybasedprospectivecohortstudy
_version_	1718394706457526272

Homocysteine and the Risk of Cardiovascular Events and All-Cause Death in Elderly Population: A Community-Based Prospective Cohort Study

Ejemplares similares