Cerebral A1 adenosine receptor availability in female and male participants and its relationship to sleep

The neuromodulator adenosine and its receptors are mediators of sleep-wake regulation which is known to differ between sexes. We, therefore, investigated sex differences in A1 adenosine receptor (A1AR) availability in healthy human subjects under well-rested conditions using [18F]CPFPX and positron...

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Autores principales:	Anna L. Pierling, Eva-Maria Elmenhorst, Denise Lange, Eva Hennecke, Diego M. Baur, Simone Beer, Tina Kroll, Bernd Neumaier, Daniel Aeschbach, Andreas Bauer, Hans-Peter Landolt, David Elmenhorst
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Adenosine receptors A1AR PET Sex differences [18F]CPFPX Sleep Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/a41ea1b9906f4daf9774164cc8bcffab
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spelling	oai:doaj.org-article:a41ea1b9906f4daf9774164cc8bcffab2021-11-04T04:26:50ZCerebral A1 adenosine receptor availability in female and male participants and its relationship to sleep1095-957210.1016/j.neuroimage.2021.118695https://doaj.org/article/a41ea1b9906f4daf9774164cc8bcffab2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S105381192100968Xhttps://doaj.org/toc/1095-9572The neuromodulator adenosine and its receptors are mediators of sleep-wake regulation which is known to differ between sexes. We, therefore, investigated sex differences in A1 adenosine receptor (A1AR) availability in healthy human subjects under well-rested conditions using [18F]CPFPX and positron emission tomography (PET). [18F]CPFPX PET scans were acquired in 50 healthy human participants (20 females; mean age ± SD 28.0 ± 5.3 years). Mean binding potential (BPND; Logan's reference tissue model with cerebellum as reference region) and volume of distribution (VT) values were calculated in 12 and 15 grey matter brain regions, respectively. [18F]CPFPX BPND was higher in females compared to males in all investigated brain regions (p < 0.025). The largest differences were found in the pallidum and anterior cingulate cortex, where mean BPND values were higher by 29% in females than in males. In females, sleep efficiency correlated positively and sleep latency negatively with BPND in most brain regions. VT values did not differ between sexes. Sleep efficiency correlated positively with VT in most brain regions in female participants. In conclusion, our analysis gives a first indication for potential sex differences in A1AR availability even under well-rested conditions. A1AR availability as measured by [18F]CPFPX BPND is higher in females compared to males. Considering the involvement of adenosine in sleep-wake control, this finding might partially explain the known sex differences in sleep efficiency and sleep latency.Anna L. PierlingEva-Maria ElmenhorstDenise LangeEva HenneckeDiego M. BaurSimone BeerTina KrollBernd NeumaierDaniel AeschbachAndreas BauerHans-Peter LandoltDavid ElmenhorstElsevierarticleAdenosine receptorsA1ARPETSex differences[18F]CPFPXSleepNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENNeuroImage, Vol 245, Iss , Pp 118695- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Adenosine receptors A1AR PET Sex differences [18F]CPFPX Sleep Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Adenosine receptors A1AR PET Sex differences [18F]CPFPX Sleep Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Anna L. Pierling Eva-Maria Elmenhorst Denise Lange Eva Hennecke Diego M. Baur Simone Beer Tina Kroll Bernd Neumaier Daniel Aeschbach Andreas Bauer Hans-Peter Landolt David Elmenhorst Cerebral A1 adenosine receptor availability in female and male participants and its relationship to sleep
description	The neuromodulator adenosine and its receptors are mediators of sleep-wake regulation which is known to differ between sexes. We, therefore, investigated sex differences in A1 adenosine receptor (A1AR) availability in healthy human subjects under well-rested conditions using [18F]CPFPX and positron emission tomography (PET). [18F]CPFPX PET scans were acquired in 50 healthy human participants (20 females; mean age ± SD 28.0 ± 5.3 years). Mean binding potential (BPND; Logan's reference tissue model with cerebellum as reference region) and volume of distribution (VT) values were calculated in 12 and 15 grey matter brain regions, respectively. [18F]CPFPX BPND was higher in females compared to males in all investigated brain regions (p < 0.025). The largest differences were found in the pallidum and anterior cingulate cortex, where mean BPND values were higher by 29% in females than in males. In females, sleep efficiency correlated positively and sleep latency negatively with BPND in most brain regions. VT values did not differ between sexes. Sleep efficiency correlated positively with VT in most brain regions in female participants. In conclusion, our analysis gives a first indication for potential sex differences in A1AR availability even under well-rested conditions. A1AR availability as measured by [18F]CPFPX BPND is higher in females compared to males. Considering the involvement of adenosine in sleep-wake control, this finding might partially explain the known sex differences in sleep efficiency and sleep latency.
format	article
author	Anna L. Pierling Eva-Maria Elmenhorst Denise Lange Eva Hennecke Diego M. Baur Simone Beer Tina Kroll Bernd Neumaier Daniel Aeschbach Andreas Bauer Hans-Peter Landolt David Elmenhorst
author_facet	Anna L. Pierling Eva-Maria Elmenhorst Denise Lange Eva Hennecke Diego M. Baur Simone Beer Tina Kroll Bernd Neumaier Daniel Aeschbach Andreas Bauer Hans-Peter Landolt David Elmenhorst
author_sort	Anna L. Pierling
title	Cerebral A1 adenosine receptor availability in female and male participants and its relationship to sleep
title_short	Cerebral A1 adenosine receptor availability in female and male participants and its relationship to sleep
title_full	Cerebral A1 adenosine receptor availability in female and male participants and its relationship to sleep
title_fullStr	Cerebral A1 adenosine receptor availability in female and male participants and its relationship to sleep
title_full_unstemmed	Cerebral A1 adenosine receptor availability in female and male participants and its relationship to sleep
title_sort	cerebral a1 adenosine receptor availability in female and male participants and its relationship to sleep
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/a41ea1b9906f4daf9774164cc8bcffab
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Cerebral A1 adenosine receptor availability in female and male participants and its relationship to sleep

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