The Polyphosphate Kinase of <named-content content-type="genus-species">Escherichia coli</named-content> Is Required for Full Production of the Genotoxin Colibactin

The Polyphosphate Kinase of <named-content content-type="genus-species">Escherichia coli</named-content> Is Required for Full Production of the Genotoxin Colibactin

ABSTRACT Colibactin induces DNA damage in mammalian cells and has been linked to the virulence of Escherichia coli and the promotion of colorectal cancer (CRC). By looking for mutants attenuated in the promoter activity of clbB encoding one of the key enzymes for the production of colibactin, we fou...

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Autores principales: Min Tang-Fichaux, Camille V. Chagneau, Nadège Bossuet-Greif, Jean-Philippe Nougayrède, Éric Oswald, Priscilla Branchu
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2020
Materias:
pks
genotoxicity
PPK
mesalamine
colibactin
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/a41f1f2131b848ea963a2694822a22c8
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