Modern management of malignant pleural mesothelioma

Shivani C Patel,1 Jonathan E Dowell1,2 1Division of Hematology and Oncology, University of Texas Southwestern, 2Section of Hematology and Oncology, Veterans Affairs North Texas Healthcare System, Dallas, TX, USA Abstract: Malignant pleural mesothelioma (MPM) is a deadly disease that produces a sign...

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Autores principales:	Patel SC, Dowell JE
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	mesothelioma asbestos chemotherapy surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/a420535fb0ac49c59fade232196eaa9c
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spelling	oai:doaj.org-article:a420535fb0ac49c59fade232196eaa9c2021-12-02T00:19:05ZModern management of malignant pleural mesothelioma1179-2728https://doaj.org/article/a420535fb0ac49c59fade232196eaa9c2016-05-01T00:00:00Zhttps://www.dovepress.com/modern-management-of-malignant-pleural-mesothelioma-peer-reviewed-article-LCTThttps://doaj.org/toc/1179-2728Shivani C Patel,1 Jonathan E Dowell1,2 1Division of Hematology and Oncology, University of Texas Southwestern, 2Section of Hematology and Oncology, Veterans Affairs North Texas Healthcare System, Dallas, TX, USA Abstract: Malignant pleural mesothelioma (MPM) is a deadly disease that produces a significant worldwide health care burden. The majority of cases are associated with prior asbestos exposure, but recent studies have identified a possible genetic predisposition in a minority of patients. Historically, obtaining a pathologic diagnosis of MPM was challenging, but with current pathological techniques, a secure diagnosis is possible in the majority of patients. Curative therapy for MPM remains elusive, and the primary treatment option for fit patients is platinum-based chemotherapy. Encouraging recent reports suggest that there may be a benefit to the addition of bevacizumab to standard chemotherapy as well as with the use of immune checkpoint inhibitors in MPM. Selected patients may be considered for aggressive surgical approaches, but there is considerable controversy regarding the true benefit of surgery and multimodality therapy in this disease. Keywords: mesothelioma, asbestos, chemotherapy, surgeryPatel SCDowell JEDove Medical PressarticlemesotheliomaasbestoschemotherapysurgeryNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENLung Cancer: Targets and Therapy, Vol 2016, Iss Issue 1, Pp 63-72 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	mesothelioma asbestos chemotherapy surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	mesothelioma asbestos chemotherapy surgery Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Patel SC Dowell JE Modern management of malignant pleural mesothelioma
description	Shivani C Patel,1 Jonathan E Dowell1,2 1Division of Hematology and Oncology, University of Texas Southwestern, 2Section of Hematology and Oncology, Veterans Affairs North Texas Healthcare System, Dallas, TX, USA Abstract: Malignant pleural mesothelioma (MPM) is a deadly disease that produces a significant worldwide health care burden. The majority of cases are associated with prior asbestos exposure, but recent studies have identified a possible genetic predisposition in a minority of patients. Historically, obtaining a pathologic diagnosis of MPM was challenging, but with current pathological techniques, a secure diagnosis is possible in the majority of patients. Curative therapy for MPM remains elusive, and the primary treatment option for fit patients is platinum-based chemotherapy. Encouraging recent reports suggest that there may be a benefit to the addition of bevacizumab to standard chemotherapy as well as with the use of immune checkpoint inhibitors in MPM. Selected patients may be considered for aggressive surgical approaches, but there is considerable controversy regarding the true benefit of surgery and multimodality therapy in this disease. Keywords: mesothelioma, asbestos, chemotherapy, surgery
format	article
author	Patel SC Dowell JE
author_facet	Patel SC Dowell JE
author_sort	Patel SC
title	Modern management of malignant pleural mesothelioma
title_short	Modern management of malignant pleural mesothelioma
title_full	Modern management of malignant pleural mesothelioma
title_fullStr	Modern management of malignant pleural mesothelioma
title_full_unstemmed	Modern management of malignant pleural mesothelioma
title_sort	modern management of malignant pleural mesothelioma
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/a420535fb0ac49c59fade232196eaa9c
work_keys_str_mv	AT patelsc modernmanagementofmalignantpleuralmesothelioma AT dowellje modernmanagementofmalignantpleuralmesothelioma
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Modern management of malignant pleural mesothelioma

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