Experimental Modeling of Osteoporosis in Animals

Experimental studies on animals under conditions of osteopenia and osteoporosis modeling significantly expand the view of the mechanisms of primary and secondary osteoporosis development, help determining the effect of various factors affecting the bone tissue, evaluate the effect of medications, ne...

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Autores principales:	N.V. Dedukh, N.N. Yakovenchuk, O.A. Nikolchenko
Formato:	article
Lenguaje:	EN RU UK
Publicado:	Zaslavsky O.Yu. 2021
Materias:	osteoporosis, osteopenia, animal modeling, rats, mice, bone pathomorphology Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a421719e8e004839bbc315c0b1d25131
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spelling	oai:doaj.org-article:a421719e8e004839bbc315c0b1d251312021-11-12T07:53:10ZExperimental Modeling of Osteoporosis in Animals2224-15072307-113310.22141/2224-1507.11.3.2021.243046https://doaj.org/article/a421719e8e004839bbc315c0b1d251312021-10-01T00:00:00Zhttp://pjs.zaslavsky.com.ua/article/view/243046https://doaj.org/toc/2224-1507https://doaj.org/toc/2307-1133Experimental studies on animals under conditions of osteopenia and osteoporosis modeling significantly expand the view of the mechanisms of primary and secondary osteoporosis development, help determining the effect of various factors affecting the bone tissue, evaluate the effect of medications, new biomaterials, etc. Osteoporosis is a multifactorial disease; its clinical manifestations depend on a complex interplay of environmental, lifestyle and genetic factors. The review of the literature analyzes the data on the use of animals to assess the features of osteoporosis course when modeling this pathology by surgical and non-surgical methods. The article features the models of osteoporosis which are reproduced on rats and mice being the most accessible objects and the most frequently used by experimenters. The details of modeling the course of such types of osteoporosis as postmenopausal, senile, glucocorticoid-induced, testosterone deficiency (orchiectomy)-induced, immobilization, hypothermia, radiation-induced, etc. are explored. A specific aspect of recent advances in modeling osteoporosis is the creation of transgenic and knockout mice, whose models may be used to detect components of genetic lesions and will certainly contribute to the development of new methods of prevention and therapy of this severe pathology. The similarity and difference of experimental models of osteoporosis describing the pathophysiological changes in humans due to osteoporosis are noted. Emphasis is placed on bioethical norms of working with experimental animals.N.V. DedukhN.N. YakovenchukO.A. NikolchenkoZaslavsky O.Yu.articleosteoporosis, osteopenia, animal modeling, rats, mice, bone pathomorphologyMedicine (General)R5-920ENRUUKBolʹ, Sustavy, Pozvonočnik, Vol 11, Iss 3, Pp 97-109 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU UK
topic	osteoporosis, osteopenia, animal modeling, rats, mice, bone pathomorphology Medicine (General) R5-920
spellingShingle	osteoporosis, osteopenia, animal modeling, rats, mice, bone pathomorphology Medicine (General) R5-920 N.V. Dedukh N.N. Yakovenchuk O.A. Nikolchenko Experimental Modeling of Osteoporosis in Animals
description	Experimental studies on animals under conditions of osteopenia and osteoporosis modeling significantly expand the view of the mechanisms of primary and secondary osteoporosis development, help determining the effect of various factors affecting the bone tissue, evaluate the effect of medications, new biomaterials, etc. Osteoporosis is a multifactorial disease; its clinical manifestations depend on a complex interplay of environmental, lifestyle and genetic factors. The review of the literature analyzes the data on the use of animals to assess the features of osteoporosis course when modeling this pathology by surgical and non-surgical methods. The article features the models of osteoporosis which are reproduced on rats and mice being the most accessible objects and the most frequently used by experimenters. The details of modeling the course of such types of osteoporosis as postmenopausal, senile, glucocorticoid-induced, testosterone deficiency (orchiectomy)-induced, immobilization, hypothermia, radiation-induced, etc. are explored. A specific aspect of recent advances in modeling osteoporosis is the creation of transgenic and knockout mice, whose models may be used to detect components of genetic lesions and will certainly contribute to the development of new methods of prevention and therapy of this severe pathology. The similarity and difference of experimental models of osteoporosis describing the pathophysiological changes in humans due to osteoporosis are noted. Emphasis is placed on bioethical norms of working with experimental animals.
format	article
author	N.V. Dedukh N.N. Yakovenchuk O.A. Nikolchenko
author_facet	N.V. Dedukh N.N. Yakovenchuk O.A. Nikolchenko
author_sort	N.V. Dedukh
title	Experimental Modeling of Osteoporosis in Animals
title_short	Experimental Modeling of Osteoporosis in Animals
title_full	Experimental Modeling of Osteoporosis in Animals
title_fullStr	Experimental Modeling of Osteoporosis in Animals
title_full_unstemmed	Experimental Modeling of Osteoporosis in Animals
title_sort	experimental modeling of osteoporosis in animals
publisher	Zaslavsky O.Yu.
publishDate	2021
url	https://doaj.org/article/a421719e8e004839bbc315c0b1d25131
work_keys_str_mv	AT nvdedukh experimentalmodelingofosteoporosisinanimals AT nnyakovenchuk experimentalmodelingofosteoporosisinanimals AT oanikolchenko experimentalmodelingofosteoporosisinanimals
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Experimental Modeling of Osteoporosis in Animals

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