p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis
Soluble misfolded proteins that fail to be degraded by the ubiquitin proteasome system (UPS) are redirected to autophagy via specific adaptors, such as p62. Here the authors show that p62 recognises N-degrons in these proteins, acting as a N-recognin from the proteolytic N-end rule pathway, and targ...
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2017
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oai:doaj.org-article:a427518b7ba242ffb3606852a4c4bba92021-12-02T13:24:14Zp62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis10.1038/s41467-017-00085-72041-1723https://doaj.org/article/a427518b7ba242ffb3606852a4c4bba92017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00085-7https://doaj.org/toc/2041-1723Soluble misfolded proteins that fail to be degraded by the ubiquitin proteasome system (UPS) are redirected to autophagy via specific adaptors, such as p62. Here the authors show that p62 recognises N-degrons in these proteins, acting as a N-recognin from the proteolytic N-end rule pathway, and targets these cargos to autophagosomal degradation.Hyunjoo Cha-MolstadJi Eun YuZhiwei FengSu Hyun LeeJung Gi KimPeng YangBitnara HanKi Woon SungYoung Dong YooJoonsung HwangTerry McGuireSang Mi ShimHyun Dong SongSrinivasrao GanipisettiNuozhou WangJun Min JangMin Jae LeeSeung Jun KimKyung Ho LeeJin Tae HongAaron CiechanoverInhee Mook-JungKwang Pyo KimXiang-Qun XieYong Tae KwonBo Yeon KimNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017) |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Hyunjoo Cha-Molstad Ji Eun Yu Zhiwei Feng Su Hyun Lee Jung Gi Kim Peng Yang Bitnara Han Ki Woon Sung Young Dong Yoo Joonsung Hwang Terry McGuire Sang Mi Shim Hyun Dong Song Srinivasrao Ganipisetti Nuozhou Wang Jun Min Jang Min Jae Lee Seung Jun Kim Kyung Ho Lee Jin Tae Hong Aaron Ciechanover Inhee Mook-Jung Kwang Pyo Kim Xiang-Qun Xie Yong Tae Kwon Bo Yeon Kim p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis |
| description |
Soluble misfolded proteins that fail to be degraded by the ubiquitin proteasome system (UPS) are redirected to autophagy via specific adaptors, such as p62. Here the authors show that p62 recognises N-degrons in these proteins, acting as a N-recognin from the proteolytic N-end rule pathway, and targets these cargos to autophagosomal degradation. |
| format |
article |
| author |
Hyunjoo Cha-Molstad Ji Eun Yu Zhiwei Feng Su Hyun Lee Jung Gi Kim Peng Yang Bitnara Han Ki Woon Sung Young Dong Yoo Joonsung Hwang Terry McGuire Sang Mi Shim Hyun Dong Song Srinivasrao Ganipisetti Nuozhou Wang Jun Min Jang Min Jae Lee Seung Jun Kim Kyung Ho Lee Jin Tae Hong Aaron Ciechanover Inhee Mook-Jung Kwang Pyo Kim Xiang-Qun Xie Yong Tae Kwon Bo Yeon Kim |
| author_facet |
Hyunjoo Cha-Molstad Ji Eun Yu Zhiwei Feng Su Hyun Lee Jung Gi Kim Peng Yang Bitnara Han Ki Woon Sung Young Dong Yoo Joonsung Hwang Terry McGuire Sang Mi Shim Hyun Dong Song Srinivasrao Ganipisetti Nuozhou Wang Jun Min Jang Min Jae Lee Seung Jun Kim Kyung Ho Lee Jin Tae Hong Aaron Ciechanover Inhee Mook-Jung Kwang Pyo Kim Xiang-Qun Xie Yong Tae Kwon Bo Yeon Kim |
| author_sort |
Hyunjoo Cha-Molstad |
| title |
p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis |
| title_short |
p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis |
| title_full |
p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis |
| title_fullStr |
p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis |
| title_full_unstemmed |
p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis |
| title_sort |
p62/sqstm1/sequestosome-1 is an n-recognin of the n-end rule pathway which modulates autophagosome biogenesis |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/a427518b7ba242ffb3606852a4c4bba9 |
| work_keys_str_mv |
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1718393111929946112 |