Inhibitory activity of selenium nanoparticles functionalized with oseltamivir on H1N1 influenza virus

Yinghua Li,1 Zhengfang Lin,1 Min Guo,1 Yu Xia,1 Mingqi Zhao,1 Changbing Wang,1 Tiantian Xu,1 Tianfeng Chen,2 Bing Zhu1 1Virus Laboratory, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, 2Department of Chemistry, Jinan Univers...

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Autores principales:	Li Y, Lin Z, Guo M, Xia Y, Zhao M, Wang C, Xu T, Chen T, Zhu B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Selenium nanoparticles Oseltamivir Influenza virus Neuraminidase Apoptosis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/a4288da65c1649c6b3957bcaee5a9e19
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spelling	oai:doaj.org-article:a4288da65c1649c6b3957bcaee5a9e192021-12-02T05:40:29ZInhibitory activity of selenium nanoparticles functionalized with oseltamivir on H1N1 influenza virus1178-2013https://doaj.org/article/a4288da65c1649c6b3957bcaee5a9e192017-08-01T00:00:00Zhttps://www.dovepress.com/inhibitory-activity-of-selenium-nanoparticles-functionalized-with-osel-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yinghua Li,1 Zhengfang Lin,1 Min Guo,1 Yu Xia,1 Mingqi Zhao,1 Changbing Wang,1 Tiantian Xu,1 Tianfeng Chen,2 Bing Zhu1 1Virus Laboratory, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, 2Department of Chemistry, Jinan University, Guangzhou, People’s Republic of China Abstract: As an effective antiviral agent, the clinical application of oseltamivir (OTV) is limited by the appearance of drug-resistant viruses. Due to their low toxicity and excellent activity, the antiviral capabilities of selenium nanoparticles (SeNPs) has attracted increasing attention in recent years. To overcome the limitation of drug resistance, the use of modified NPs with biologics to explore novel anti-influenza drugs is developing rapidly. In this study, OTV surface-modified SeNPs with superior antiviral properties and restriction on drug resistance were synthesized. OTV decoration of SeNPs (Se@OTV) obviously inhibited H1N1 infection and had less toxicity. Se@OTV interfered with the H1N1 influenza virus to host cells through inhibiting the activity of hemagglutinin and neuraminidase. The mechanism was that Se@OTV was able to prevent H1N1 from infecting MDCK cells and block chromatin condensation and DNA fragmentation. Furthermore, Se@OTV inhibited the generation of reactive oxygen species and activation of p53 phosphorylation and Akt. These results demonstrate that Se@OTV is a promising efficient antiviral pharmaceutical for H1N1. Keywords: selenium nanoparticles, oseltamivir, influenza virus, neuraminidase, apoptosis Li YLin ZGuo MXia YZhao MWang CXu TChen TZhu BDove Medical PressarticleSelenium nanoparticlesOseltamivirInfluenza virusNeuraminidaseApoptosisMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 5733-5743 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Selenium nanoparticles Oseltamivir Influenza virus Neuraminidase Apoptosis Medicine (General) R5-920
spellingShingle	Selenium nanoparticles Oseltamivir Influenza virus Neuraminidase Apoptosis Medicine (General) R5-920 Li Y Lin Z Guo M Xia Y Zhao M Wang C Xu T Chen T Zhu B Inhibitory activity of selenium nanoparticles functionalized with oseltamivir on H1N1 influenza virus
description	Yinghua Li,1 Zhengfang Lin,1 Min Guo,1 Yu Xia,1 Mingqi Zhao,1 Changbing Wang,1 Tiantian Xu,1 Tianfeng Chen,2 Bing Zhu1 1Virus Laboratory, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, 2Department of Chemistry, Jinan University, Guangzhou, People’s Republic of China Abstract: As an effective antiviral agent, the clinical application of oseltamivir (OTV) is limited by the appearance of drug-resistant viruses. Due to their low toxicity and excellent activity, the antiviral capabilities of selenium nanoparticles (SeNPs) has attracted increasing attention in recent years. To overcome the limitation of drug resistance, the use of modified NPs with biologics to explore novel anti-influenza drugs is developing rapidly. In this study, OTV surface-modified SeNPs with superior antiviral properties and restriction on drug resistance were synthesized. OTV decoration of SeNPs (Se@OTV) obviously inhibited H1N1 infection and had less toxicity. Se@OTV interfered with the H1N1 influenza virus to host cells through inhibiting the activity of hemagglutinin and neuraminidase. The mechanism was that Se@OTV was able to prevent H1N1 from infecting MDCK cells and block chromatin condensation and DNA fragmentation. Furthermore, Se@OTV inhibited the generation of reactive oxygen species and activation of p53 phosphorylation and Akt. These results demonstrate that Se@OTV is a promising efficient antiviral pharmaceutical for H1N1. Keywords: selenium nanoparticles, oseltamivir, influenza virus, neuraminidase, apoptosis
format	article
author	Li Y Lin Z Guo M Xia Y Zhao M Wang C Xu T Chen T Zhu B
author_facet	Li Y Lin Z Guo M Xia Y Zhao M Wang C Xu T Chen T Zhu B
author_sort	Li Y
title	Inhibitory activity of selenium nanoparticles functionalized with oseltamivir on H1N1 influenza virus
title_short	Inhibitory activity of selenium nanoparticles functionalized with oseltamivir on H1N1 influenza virus
title_full	Inhibitory activity of selenium nanoparticles functionalized with oseltamivir on H1N1 influenza virus
title_fullStr	Inhibitory activity of selenium nanoparticles functionalized with oseltamivir on H1N1 influenza virus
title_full_unstemmed	Inhibitory activity of selenium nanoparticles functionalized with oseltamivir on H1N1 influenza virus
title_sort	inhibitory activity of selenium nanoparticles functionalized with oseltamivir on h1n1 influenza virus
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/a4288da65c1649c6b3957bcaee5a9e19
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Inhibitory activity of selenium nanoparticles functionalized with oseltamivir on H1N1 influenza virus

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