What Do We Know about Inequalities in NAFLD Distribution and Outcomes? A Scoping Review

With prevalence high and rising given the close relationship with obesity and diabetes mellitus, non-alcoholic fatty liver disease (NAFLD) is progressively becoming the most common chronic liver condition worldwide. However, little is known about the health inequalities in NAFLD distribution and out...

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Autores principales:	Mar Talens, Natalia Tumas, Jeffrey V. Lazarus, Joan Benach, Juan M. Pericàs
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	non-alcoholic fatty liver disease health inequalities social determinants of health Medicine R
Acceso en línea:	https://doaj.org/article/a42c00b753864be7acc2cd161357fbaf
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spelling	oai:doaj.org-article:a42c00b753864be7acc2cd161357fbaf2021-11-11T17:38:53ZWhat Do We Know about Inequalities in NAFLD Distribution and Outcomes? A Scoping Review10.3390/jcm102150192077-0383https://doaj.org/article/a42c00b753864be7acc2cd161357fbaf2021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5019https://doaj.org/toc/2077-0383With prevalence high and rising given the close relationship with obesity and diabetes mellitus, non-alcoholic fatty liver disease (NAFLD) is progressively becoming the most common chronic liver condition worldwide. However, little is known about the health inequalities in NAFLD distribution and outcomes. This review aims to analyze health inequalities in NAFLD distribution globally and to assess the health disparities in NAFLD-related outcomes. We conducted a scoping review of global health inequalities in NAFLD distribution and outcomes according to gender/sex, ethnicity/race, and socioeconomic position from PubMed’s inception to May 2021. Ultimately, 20 articles were included in the review, most (75%) of them carried out in the United States. Males were found to have a higher NAFLD prevalence (three articles), while available evidence suggests that women have an overall higher burden of advanced liver disease and complications (four articles), whereas they are less likely to be liver-transplanted once cirrhosis develops (one article). In the US, the Hispanic population had the highest NAFLD prevalence and poorer outcomes (seven articles), whereas Whites had fewer complications than other ethnicities (two articles). Patients with low socioeconomic status had higher NAFLD prevalence (four articles) and a higher likelihood of progression and complications (five articles). In conclusion, globally there is a lack of studies analyzing NAFLD prevalence and outcomes according to various axes of inequality through joint intersectional appraisals, and most studies included in our review were based on the US population. Available evidence suggests that NAFLD distribution and outcomes show large inequalities by social group. Further research on this issue is warranted.Mar TalensNatalia TumasJeffrey V. LazarusJoan BenachJuan M. PericàsMDPI AGarticlenon-alcoholic fatty liver diseasehealth inequalitiessocial determinants of healthMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5019, p 5019 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	non-alcoholic fatty liver disease health inequalities social determinants of health Medicine R
spellingShingle	non-alcoholic fatty liver disease health inequalities social determinants of health Medicine R Mar Talens Natalia Tumas Jeffrey V. Lazarus Joan Benach Juan M. Pericàs What Do We Know about Inequalities in NAFLD Distribution and Outcomes? A Scoping Review
description	With prevalence high and rising given the close relationship with obesity and diabetes mellitus, non-alcoholic fatty liver disease (NAFLD) is progressively becoming the most common chronic liver condition worldwide. However, little is known about the health inequalities in NAFLD distribution and outcomes. This review aims to analyze health inequalities in NAFLD distribution globally and to assess the health disparities in NAFLD-related outcomes. We conducted a scoping review of global health inequalities in NAFLD distribution and outcomes according to gender/sex, ethnicity/race, and socioeconomic position from PubMed’s inception to May 2021. Ultimately, 20 articles were included in the review, most (75%) of them carried out in the United States. Males were found to have a higher NAFLD prevalence (three articles), while available evidence suggests that women have an overall higher burden of advanced liver disease and complications (four articles), whereas they are less likely to be liver-transplanted once cirrhosis develops (one article). In the US, the Hispanic population had the highest NAFLD prevalence and poorer outcomes (seven articles), whereas Whites had fewer complications than other ethnicities (two articles). Patients with low socioeconomic status had higher NAFLD prevalence (four articles) and a higher likelihood of progression and complications (five articles). In conclusion, globally there is a lack of studies analyzing NAFLD prevalence and outcomes according to various axes of inequality through joint intersectional appraisals, and most studies included in our review were based on the US population. Available evidence suggests that NAFLD distribution and outcomes show large inequalities by social group. Further research on this issue is warranted.
format	article
author	Mar Talens Natalia Tumas Jeffrey V. Lazarus Joan Benach Juan M. Pericàs
author_facet	Mar Talens Natalia Tumas Jeffrey V. Lazarus Joan Benach Juan M. Pericàs
author_sort	Mar Talens
title	What Do We Know about Inequalities in NAFLD Distribution and Outcomes? A Scoping Review
title_short	What Do We Know about Inequalities in NAFLD Distribution and Outcomes? A Scoping Review
title_full	What Do We Know about Inequalities in NAFLD Distribution and Outcomes? A Scoping Review
title_fullStr	What Do We Know about Inequalities in NAFLD Distribution and Outcomes? A Scoping Review
title_full_unstemmed	What Do We Know about Inequalities in NAFLD Distribution and Outcomes? A Scoping Review
title_sort	what do we know about inequalities in nafld distribution and outcomes? a scoping review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a42c00b753864be7acc2cd161357fbaf
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What Do We Know about Inequalities in NAFLD Distribution and Outcomes? A Scoping Review

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