Epidemiology of classical Hodgkin lymphoma and its association with Epstein Barr virus in Northern China.

<h4>Background</h4>The incidence of classical Hodgkin lymphoma (cHL) and its association with Epstein-Barr virus (EBV) varies significantly with age, sex, ethnicity and geographic location. This is the first report on epidemiological features of cHL patients from Northern regions of Chin...

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Autores principales:	Xin Huang, Ilja Nolte, Zifen Gao, Hans Vos, Bouke Hepkema, Sibrand Poppema, Anke van den Berg, Arjan Diepstra
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a42cc37fd59c46959cddee27e9d705d1
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spelling	oai:doaj.org-article:a42cc37fd59c46959cddee27e9d705d12021-11-18T06:52:17ZEpidemiology of classical Hodgkin lymphoma and its association with Epstein Barr virus in Northern China.1932-620310.1371/journal.pone.0021152https://doaj.org/article/a42cc37fd59c46959cddee27e9d705d12011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21695175/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The incidence of classical Hodgkin lymphoma (cHL) and its association with Epstein-Barr virus (EBV) varies significantly with age, sex, ethnicity and geographic location. This is the first report on epidemiological features of cHL patients from Northern regions of China. These features are compared to data from a previously published Dutch cHL population.<h4>Methodology/principal findings</h4>157 cHL patients diagnosed between 1997 and 2008 in the North of China were included after histopathological re-evaluation. The Dutch population-based cohort consisted of 515 cHL patients diagnosed between 1987 and 2000. EBV status was determined by in situ hybridization of EBV- encoded small RNAs. In the Chinese population, tumor cells of 39% of the cHL patients were EBV+ and this was significantly associated with male sex, mixed cellularity subtype and young age (<20 y). The median age of the Chinese patients was 9 years younger than that of the Dutch patients (28 y vs. 37 y). In addition, the age distribution between the two populations was strikingly different in both the EBV+ subgroups (p<0.001) and the EBV- subgroups (p = 0.01). The mixed cellularity subtype was almost 3x more frequent amongst the Chinese (p<0.001).<h4>Conclusion/significance</h4>CHL patients from Northern regions of China show a distinctive age distribution pattern with a striking incidence peak of EBV+ mixed cellularity cases among children and adolescents and another high incidence peak of EBV- nodular sclerosis cases in young adults. In comparison to Dutch cHL patients there are pronounced differences in age distribution, subtype and EBV status, presumably caused by complex gene-environmental interactions.Xin HuangIlja NolteZifen GaoHans VosBouke HepkemaSibrand PoppemaAnke van den BergArjan DiepstraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e21152 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xin Huang Ilja Nolte Zifen Gao Hans Vos Bouke Hepkema Sibrand Poppema Anke van den Berg Arjan Diepstra Epidemiology of classical Hodgkin lymphoma and its association with Epstein Barr virus in Northern China.
description	<h4>Background</h4>The incidence of classical Hodgkin lymphoma (cHL) and its association with Epstein-Barr virus (EBV) varies significantly with age, sex, ethnicity and geographic location. This is the first report on epidemiological features of cHL patients from Northern regions of China. These features are compared to data from a previously published Dutch cHL population.<h4>Methodology/principal findings</h4>157 cHL patients diagnosed between 1997 and 2008 in the North of China were included after histopathological re-evaluation. The Dutch population-based cohort consisted of 515 cHL patients diagnosed between 1987 and 2000. EBV status was determined by in situ hybridization of EBV- encoded small RNAs. In the Chinese population, tumor cells of 39% of the cHL patients were EBV+ and this was significantly associated with male sex, mixed cellularity subtype and young age (<20 y). The median age of the Chinese patients was 9 years younger than that of the Dutch patients (28 y vs. 37 y). In addition, the age distribution between the two populations was strikingly different in both the EBV+ subgroups (p<0.001) and the EBV- subgroups (p = 0.01). The mixed cellularity subtype was almost 3x more frequent amongst the Chinese (p<0.001).<h4>Conclusion/significance</h4>CHL patients from Northern regions of China show a distinctive age distribution pattern with a striking incidence peak of EBV+ mixed cellularity cases among children and adolescents and another high incidence peak of EBV- nodular sclerosis cases in young adults. In comparison to Dutch cHL patients there are pronounced differences in age distribution, subtype and EBV status, presumably caused by complex gene-environmental interactions.
format	article
author	Xin Huang Ilja Nolte Zifen Gao Hans Vos Bouke Hepkema Sibrand Poppema Anke van den Berg Arjan Diepstra
author_facet	Xin Huang Ilja Nolte Zifen Gao Hans Vos Bouke Hepkema Sibrand Poppema Anke van den Berg Arjan Diepstra
author_sort	Xin Huang
title	Epidemiology of classical Hodgkin lymphoma and its association with Epstein Barr virus in Northern China.
title_short	Epidemiology of classical Hodgkin lymphoma and its association with Epstein Barr virus in Northern China.
title_full	Epidemiology of classical Hodgkin lymphoma and its association with Epstein Barr virus in Northern China.
title_fullStr	Epidemiology of classical Hodgkin lymphoma and its association with Epstein Barr virus in Northern China.
title_full_unstemmed	Epidemiology of classical Hodgkin lymphoma and its association with Epstein Barr virus in Northern China.
title_sort	epidemiology of classical hodgkin lymphoma and its association with epstein barr virus in northern china.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/a42cc37fd59c46959cddee27e9d705d1
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Epidemiology of classical Hodgkin lymphoma and its association with Epstein Barr virus in Northern China.

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