Maternal Perinatal Characteristics in Patients with Severe Preeclampsia: A Case-Control Nested Cohort Study

Preeclampsia is one of the most worrisome complications during pregnancy, affecting approximately 1 out of 20 women worldwide. Preeclampsia is mainly characterized by a sustained hypertension, proteinuria, also involving a significant organ dysfunction. Moreover, 25% of the cases could be classified...

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Autores principales:	Irene Aracil Moreno, Patrocinio Rodríguez-Benitez, Maria Ruiz-Minaya, Mireia Bernal Claverol, Virginia Ortega Abad, Concepción Hernández Martin, Pilar Pintado Recarte, Fátima Yllana, Cristina Oliver-Barrecheguren, Melchor Álvarez-Mon, Miguel A. Ortega, Juan A. De Leon-Luis
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	severe preeclampsia maternal risk factors pregnancy outcome Medicine R
Acceso en línea:	https://doaj.org/article/a42cf12c3baa49d8897d798812b074cf
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spelling	oai:doaj.org-article:a42cf12c3baa49d8897d798812b074cf2021-11-25T17:48:20ZMaternal Perinatal Characteristics in Patients with Severe Preeclampsia: A Case-Control Nested Cohort Study10.3390/ijerph1822117831660-46011661-7827https://doaj.org/article/a42cf12c3baa49d8897d798812b074cf2021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/22/11783https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Preeclampsia is one of the most worrisome complications during pregnancy, affecting approximately 1 out of 20 women worldwide. Preeclampsia is mainly characterized by a sustained hypertension, proteinuria, also involving a significant organ dysfunction. Moreover, 25% of the cases could be classified as severe preeclampsia (SP), a serious condition that could be life-threatening for both the mother and fetus. Although there are many studies focusing on preeclampsia, less efforts have been made in SP, frequently limited to some specific situations. Thus, the present study aims to conduct a comparative analysis of risk factors, maternal characteristics, obstetric and neonatal outcomes and maternal complications in patients with severe preeclampsia versus patients without severe preeclampsia. Hence, 235 cases and 470 controls were evaluated and followed in our study. We described a set of variables related to the development of severe preeclampsia, including maternal age > 35 years (69.8%), gestational (26.8%) or chronic arterial hypertension (18.3%), obesity (22.6%), use of assisted reproduction techniques (12.3%), prior history of preeclampsia (10.2%) and chronic kidney disease (7.7%) All patients had severe hypertension (>160 mmHg) and some of them presented with additional complications, such as acute renal failure (51 cases), HELLP syndrome (22 cases), eclampsia (9 cases) and acute cerebrovascular accidents (3 cases). No case of maternal death was recorded, although the SP group had a higher cesarean section rate than the control group (60% vs. 20.9%) (<i>p</i> < 0.001), and there was a notably higher perinatal morbidity and mortality in these patients, who had a prematurity rate of 58.3% (<i>p</i> < 0.001) and 14 perinatal deaths, compared to 1 in the control group. Overall, our study recognized a series of factors related to the development of SP and related complications, which may be of great aid for improving the clinical management of this condition.Irene Aracil MorenoPatrocinio Rodríguez-BenitezMaria Ruiz-MinayaMireia Bernal ClaverolVirginia Ortega AbadConcepción Hernández MartinPilar Pintado RecarteFátima YllanaCristina Oliver-BarrechegurenMelchor Álvarez-MonMiguel A. OrtegaJuan A. De Leon-LuisMDPI AGarticlesevere preeclampsiamaternal risk factorspregnancy outcomeMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11783, p 11783 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	severe preeclampsia maternal risk factors pregnancy outcome Medicine R
spellingShingle	severe preeclampsia maternal risk factors pregnancy outcome Medicine R Irene Aracil Moreno Patrocinio Rodríguez-Benitez Maria Ruiz-Minaya Mireia Bernal Claverol Virginia Ortega Abad Concepción Hernández Martin Pilar Pintado Recarte Fátima Yllana Cristina Oliver-Barrecheguren Melchor Álvarez-Mon Miguel A. Ortega Juan A. De Leon-Luis Maternal Perinatal Characteristics in Patients with Severe Preeclampsia: A Case-Control Nested Cohort Study
description	Preeclampsia is one of the most worrisome complications during pregnancy, affecting approximately 1 out of 20 women worldwide. Preeclampsia is mainly characterized by a sustained hypertension, proteinuria, also involving a significant organ dysfunction. Moreover, 25% of the cases could be classified as severe preeclampsia (SP), a serious condition that could be life-threatening for both the mother and fetus. Although there are many studies focusing on preeclampsia, less efforts have been made in SP, frequently limited to some specific situations. Thus, the present study aims to conduct a comparative analysis of risk factors, maternal characteristics, obstetric and neonatal outcomes and maternal complications in patients with severe preeclampsia versus patients without severe preeclampsia. Hence, 235 cases and 470 controls were evaluated and followed in our study. We described a set of variables related to the development of severe preeclampsia, including maternal age > 35 years (69.8%), gestational (26.8%) or chronic arterial hypertension (18.3%), obesity (22.6%), use of assisted reproduction techniques (12.3%), prior history of preeclampsia (10.2%) and chronic kidney disease (7.7%) All patients had severe hypertension (>160 mmHg) and some of them presented with additional complications, such as acute renal failure (51 cases), HELLP syndrome (22 cases), eclampsia (9 cases) and acute cerebrovascular accidents (3 cases). No case of maternal death was recorded, although the SP group had a higher cesarean section rate than the control group (60% vs. 20.9%) (<i>p</i> < 0.001), and there was a notably higher perinatal morbidity and mortality in these patients, who had a prematurity rate of 58.3% (<i>p</i> < 0.001) and 14 perinatal deaths, compared to 1 in the control group. Overall, our study recognized a series of factors related to the development of SP and related complications, which may be of great aid for improving the clinical management of this condition.
format	article
author	Irene Aracil Moreno Patrocinio Rodríguez-Benitez Maria Ruiz-Minaya Mireia Bernal Claverol Virginia Ortega Abad Concepción Hernández Martin Pilar Pintado Recarte Fátima Yllana Cristina Oliver-Barrecheguren Melchor Álvarez-Mon Miguel A. Ortega Juan A. De Leon-Luis
author_facet	Irene Aracil Moreno Patrocinio Rodríguez-Benitez Maria Ruiz-Minaya Mireia Bernal Claverol Virginia Ortega Abad Concepción Hernández Martin Pilar Pintado Recarte Fátima Yllana Cristina Oliver-Barrecheguren Melchor Álvarez-Mon Miguel A. Ortega Juan A. De Leon-Luis
author_sort	Irene Aracil Moreno
title	Maternal Perinatal Characteristics in Patients with Severe Preeclampsia: A Case-Control Nested Cohort Study
title_short	Maternal Perinatal Characteristics in Patients with Severe Preeclampsia: A Case-Control Nested Cohort Study
title_full	Maternal Perinatal Characteristics in Patients with Severe Preeclampsia: A Case-Control Nested Cohort Study
title_fullStr	Maternal Perinatal Characteristics in Patients with Severe Preeclampsia: A Case-Control Nested Cohort Study
title_full_unstemmed	Maternal Perinatal Characteristics in Patients with Severe Preeclampsia: A Case-Control Nested Cohort Study
title_sort	maternal perinatal characteristics in patients with severe preeclampsia: a case-control nested cohort study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a42cf12c3baa49d8897d798812b074cf
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Maternal Perinatal Characteristics in Patients with Severe Preeclampsia: A Case-Control Nested Cohort Study

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