Soluble vascular cell adhesion molecule-1 levels and severity of dengue hemorrhagic fever in children

Background The clinical manifestations of dengue infection vary widely, ranging from asymptomatic to severe forms that can cause death. In severe infections, the expression of soluble vascular cell adhesion molecule-1 (sVCAM-1) in endothelial cells is reportedly excessive, causing endothelial cell g...

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Autores principales:	Nolitriani Nolitriani, Rinang Mariko, Mayetti Mayetti
Formato:	article
Lenguaje:	EN
Publicado:	Indonesian Pediatric Society Publishing House 2021
Materias:	pediatric, dengue hemorrhagic fever, svcam-1 Medicine R Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/a42f21a92f3649b386da3eb2a0b47910
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spelling	oai:doaj.org-article:a42f21a92f3649b386da3eb2a0b479102021-11-29T02:29:22ZSoluble vascular cell adhesion molecule-1 levels and severity of dengue hemorrhagic fever in children0030-93112338-476X10.14238/pi61.6.2021.328-35https://doaj.org/article/a42f21a92f3649b386da3eb2a0b479102021-11-01T00:00:00Zhttps://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/2644https://doaj.org/toc/0030-9311https://doaj.org/toc/2338-476XBackground The clinical manifestations of dengue infection vary widely, ranging from asymptomatic to severe forms that can cause death. In severe infections, the expression of soluble vascular cell adhesion molecule-1 (sVCAM-1) in endothelial cells is reportedly excessive, causing endothelial cell gaps through VE-cadherin and plasma leakage, which is the basic mechanism for shock in dengue hemorrhagic fever (DHF). Objective To determine the association between sVCAM-1 levels and severity of dengue hemorrhagic fever in children. Methods This cross-sectional study was done in children with DHF at Dr. M. Djamil Hospital, Padang, West Sumatera. Subjects were diagnosed according to the 2011 WHO criteria and selected by consecutive sampling. They were grouped as DHF with or without shock. Examination of sVCAM-1 levels was done by ELISA method. Mann-Whitney test with a significance of P<0.05 was used for statistical analysis. Results A total of 66 patients were collected from January 2018 to December 2019, but 2 patients were excluded. The 64 subjects who met the inclusion criteria consisted of 32 (50%) DHF without shock and 32 (50%) DHF with shock. Median sVCAM-1 was significantly higher in the DHF with shock group (840 ng/mL) than in DHF without shock group (598 ng/mL) (P<0.05). Conclusion There was a significant association between higher sVCAM-1 levels and greater severity of dengue hemorrhagic fever in children.Nolitriani NolitrianiRinang MarikoMayetti MayettiIndonesian Pediatric Society Publishing Housearticlepediatric, dengue hemorrhagic fever, svcam-1MedicineRPediatricsRJ1-570ENPaediatrica Indonesiana, Vol 61, Iss 6, Pp 328-35 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pediatric, dengue hemorrhagic fever, svcam-1 Medicine R Pediatrics RJ1-570
spellingShingle	pediatric, dengue hemorrhagic fever, svcam-1 Medicine R Pediatrics RJ1-570 Nolitriani Nolitriani Rinang Mariko Mayetti Mayetti Soluble vascular cell adhesion molecule-1 levels and severity of dengue hemorrhagic fever in children
description	Background The clinical manifestations of dengue infection vary widely, ranging from asymptomatic to severe forms that can cause death. In severe infections, the expression of soluble vascular cell adhesion molecule-1 (sVCAM-1) in endothelial cells is reportedly excessive, causing endothelial cell gaps through VE-cadherin and plasma leakage, which is the basic mechanism for shock in dengue hemorrhagic fever (DHF). Objective To determine the association between sVCAM-1 levels and severity of dengue hemorrhagic fever in children. Methods This cross-sectional study was done in children with DHF at Dr. M. Djamil Hospital, Padang, West Sumatera. Subjects were diagnosed according to the 2011 WHO criteria and selected by consecutive sampling. They were grouped as DHF with or without shock. Examination of sVCAM-1 levels was done by ELISA method. Mann-Whitney test with a significance of P<0.05 was used for statistical analysis. Results A total of 66 patients were collected from January 2018 to December 2019, but 2 patients were excluded. The 64 subjects who met the inclusion criteria consisted of 32 (50%) DHF without shock and 32 (50%) DHF with shock. Median sVCAM-1 was significantly higher in the DHF with shock group (840 ng/mL) than in DHF without shock group (598 ng/mL) (P<0.05). Conclusion There was a significant association between higher sVCAM-1 levels and greater severity of dengue hemorrhagic fever in children.
format	article
author	Nolitriani Nolitriani Rinang Mariko Mayetti Mayetti
author_facet	Nolitriani Nolitriani Rinang Mariko Mayetti Mayetti
author_sort	Nolitriani Nolitriani
title	Soluble vascular cell adhesion molecule-1 levels and severity of dengue hemorrhagic fever in children
title_short	Soluble vascular cell adhesion molecule-1 levels and severity of dengue hemorrhagic fever in children
title_full	Soluble vascular cell adhesion molecule-1 levels and severity of dengue hemorrhagic fever in children
title_fullStr	Soluble vascular cell adhesion molecule-1 levels and severity of dengue hemorrhagic fever in children
title_full_unstemmed	Soluble vascular cell adhesion molecule-1 levels and severity of dengue hemorrhagic fever in children
title_sort	soluble vascular cell adhesion molecule-1 levels and severity of dengue hemorrhagic fever in children
publisher	Indonesian Pediatric Society Publishing House
publishDate	2021
url	https://doaj.org/article/a42f21a92f3649b386da3eb2a0b47910
work_keys_str_mv	AT nolitrianinolitriani solublevascularcelladhesionmolecule1levelsandseverityofdenguehemorrhagicfeverinchildren AT rinangmariko solublevascularcelladhesionmolecule1levelsandseverityofdenguehemorrhagicfeverinchildren AT mayettimayetti solublevascularcelladhesionmolecule1levelsandseverityofdenguehemorrhagicfeverinchildren
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Soluble vascular cell adhesion molecule-1 levels and severity of dengue hemorrhagic fever in children

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