TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression

TRIM24 is stabilized in SPOP-mutated prostate cancers, but the regulation of TRIM24 in wild-type prostate cancers is unknown. Here, the authors show that TRIM28 interacts with TRIM24 to prevent SPOP-mediated ubiquitination of TRIM24 and enhances TRIM24 and AR signaling to induce prostate cancer tumo...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ka-wing Fong, Jonathan C. Zhao, Bing Song, Bin Zheng, Jindan Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a430e7c9c63d4512a8f2226634658d66
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a430e7c9c63d4512a8f2226634658d66
record_format	dspace
spelling	oai:doaj.org-article:a430e7c9c63d4512a8f2226634658d662021-12-02T16:49:33ZTRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression10.1038/s41467-018-07475-52041-1723https://doaj.org/article/a430e7c9c63d4512a8f2226634658d662018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07475-5https://doaj.org/toc/2041-1723TRIM24 is stabilized in SPOP-mutated prostate cancers, but the regulation of TRIM24 in wild-type prostate cancers is unknown. Here, the authors show that TRIM28 interacts with TRIM24 to prevent SPOP-mediated ubiquitination of TRIM24 and enhances TRIM24 and AR signaling to induce prostate cancer tumorigenesis.Ka-wing FongJonathan C. ZhaoBing SongBin ZhengJindan YuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ka-wing Fong Jonathan C. Zhao Bing Song Bin Zheng Jindan Yu TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression
description	TRIM24 is stabilized in SPOP-mutated prostate cancers, but the regulation of TRIM24 in wild-type prostate cancers is unknown. Here, the authors show that TRIM28 interacts with TRIM24 to prevent SPOP-mediated ubiquitination of TRIM24 and enhances TRIM24 and AR signaling to induce prostate cancer tumorigenesis.
format	article
author	Ka-wing Fong Jonathan C. Zhao Bing Song Bin Zheng Jindan Yu
author_facet	Ka-wing Fong Jonathan C. Zhao Bing Song Bin Zheng Jindan Yu
author_sort	Ka-wing Fong
title	TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression
title_short	TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression
title_full	TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression
title_fullStr	TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression
title_full_unstemmed	TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression
title_sort	trim28 protects trim24 from spop-mediated degradation and promotes prostate cancer progression
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/a430e7c9c63d4512a8f2226634658d66
work_keys_str_mv	AT kawingfong trim28protectstrim24fromspopmediateddegradationandpromotesprostatecancerprogression AT jonathanczhao trim28protectstrim24fromspopmediateddegradationandpromotesprostatecancerprogression AT bingsong trim28protectstrim24fromspopmediateddegradationandpromotesprostatecancerprogression AT binzheng trim28protectstrim24fromspopmediateddegradationandpromotesprostatecancerprogression AT jindanyu trim28protectstrim24fromspopmediateddegradationandpromotesprostatecancerprogression
_version_	1718383294663360512

TRIM28 protects TRIM24 from SPOP-mediated degradation and promotes prostate cancer progression

Ejemplares similares