The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration

Fibroblast growth factors (FGFs) are a large family of secretory molecules that act through tyrosine kinase receptors known as FGF receptors. They play crucial roles in a wide variety of cellular functions, including cell proliferation, survival, metabolism, morphogenesis, and differentiation, as we...

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Autores principales:	Mariya Farooq, Abdul Waheed Khan, Moon Suk Kim, Sangdun Choi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	FGF FGFR tissue repair tissue regeneration cell proliferation cell differentiation Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a4312aca583c4c55b03c327910579722
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spelling	oai:doaj.org-article:a4312aca583c4c55b03c3279105797222021-11-25T17:13:12ZThe Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration10.3390/cells101132422073-4409https://doaj.org/article/a4312aca583c4c55b03c3279105797222021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3242https://doaj.org/toc/2073-4409Fibroblast growth factors (FGFs) are a large family of secretory molecules that act through tyrosine kinase receptors known as FGF receptors. They play crucial roles in a wide variety of cellular functions, including cell proliferation, survival, metabolism, morphogenesis, and differentiation, as well as in tissue repair and regeneration. The signaling pathways regulated by FGFs include RAS/mitogen-activated protein kinase (MAPK), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)–protein kinase B (AKT), phospholipase C gamma (PLCγ), and signal transducer and activator of transcription (STAT). To date, 22 FGFs have been discovered, involved in different functions in the body. Several FGFs directly or indirectly interfere with repair during tissue regeneration, in addition to their critical functions in the maintenance of pluripotency and dedifferentiation of stem cells. In this review, we summarize the roles of FGFs in diverse cellular processes and shed light on the importance of FGF signaling in mechanisms of tissue repair and regeneration.Mariya FarooqAbdul Waheed KhanMoon Suk KimSangdun ChoiMDPI AGarticleFGFFGFRtissue repairtissue regenerationcell proliferationcell differentiationBiology (General)QH301-705.5ENCells, Vol 10, Iss 3242, p 3242 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	FGF FGFR tissue repair tissue regeneration cell proliferation cell differentiation Biology (General) QH301-705.5
spellingShingle	FGF FGFR tissue repair tissue regeneration cell proliferation cell differentiation Biology (General) QH301-705.5 Mariya Farooq Abdul Waheed Khan Moon Suk Kim Sangdun Choi The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration
description	Fibroblast growth factors (FGFs) are a large family of secretory molecules that act through tyrosine kinase receptors known as FGF receptors. They play crucial roles in a wide variety of cellular functions, including cell proliferation, survival, metabolism, morphogenesis, and differentiation, as well as in tissue repair and regeneration. The signaling pathways regulated by FGFs include RAS/mitogen-activated protein kinase (MAPK), phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)–protein kinase B (AKT), phospholipase C gamma (PLCγ), and signal transducer and activator of transcription (STAT). To date, 22 FGFs have been discovered, involved in different functions in the body. Several FGFs directly or indirectly interfere with repair during tissue regeneration, in addition to their critical functions in the maintenance of pluripotency and dedifferentiation of stem cells. In this review, we summarize the roles of FGFs in diverse cellular processes and shed light on the importance of FGF signaling in mechanisms of tissue repair and regeneration.
format	article
author	Mariya Farooq Abdul Waheed Khan Moon Suk Kim Sangdun Choi
author_facet	Mariya Farooq Abdul Waheed Khan Moon Suk Kim Sangdun Choi
author_sort	Mariya Farooq
title	The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration
title_short	The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration
title_full	The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration
title_fullStr	The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration
title_full_unstemmed	The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration
title_sort	role of fibroblast growth factor (fgf) signaling in tissue repair and regeneration
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a4312aca583c4c55b03c327910579722
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The Role of Fibroblast Growth Factor (FGF) Signaling in Tissue Repair and Regeneration

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