The Emergence of Human Coronavirus EMC: How Scared Should We Be?

ABSTRACT A novel betacoronavirus, human coronavirus (HCoV-EMC), has recently been detected in humans with severe respiratory disease. Further characterization of HCoV-EMC suggests that this virus is different from severe acute respiratory syndrome coronavirus (SARS-CoV) because it is able to replica...

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Autores principales:	Renee W. Y. Chan, Leo L. M. Poon
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2013
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/a43291164c4d4fbc84818c174c37918a
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spelling	oai:doaj.org-article:a43291164c4d4fbc84818c174c37918a2021-11-15T15:40:30ZThe Emergence of Human Coronavirus EMC: How Scared Should We Be?10.1128/mBio.00191-132150-7511https://doaj.org/article/a43291164c4d4fbc84818c174c37918a2013-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00191-13https://doaj.org/toc/2150-7511ABSTRACT A novel betacoronavirus, human coronavirus (HCoV-EMC), has recently been detected in humans with severe respiratory disease. Further characterization of HCoV-EMC suggests that this virus is different from severe acute respiratory syndrome coronavirus (SARS-CoV) because it is able to replicate in multiple mammalian cell lines and it does not use angiotensin-converting enzyme 2 as a receptor to achieve infection. Additional research is urgently needed to better understand the pathogenicity and tissue tropism of this virus in humans. In their recent study published in mBio, Kindler et al. shed some light on these important topics (E. Kindler, H. R. Jónsdóttir, M. Muth, O. J. Hamming, R. Hartmann, R. Rodriguez, R. Geffers, R. A. Fouchier, C. Drosten, M. A. Müller, R. Dijkman, and V. Thiel, mBio 4[1]:e00611-12, 2013). These authors report the use of differentiated pseudostratified human primary airway epithelial cells, an in vitro model with high physiological relevance to the human airway epithelium, to characterize the cellular tropism of HCoV-EMC. More importantly, the authors demonstrate the potential use of type I and type III interferons (IFNs) to control viral infection.Renee W. Y. ChanLeo L. M. PoonAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 4, Iss 2 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Renee W. Y. Chan Leo L. M. Poon The Emergence of Human Coronavirus EMC: How Scared Should We Be?
description	ABSTRACT A novel betacoronavirus, human coronavirus (HCoV-EMC), has recently been detected in humans with severe respiratory disease. Further characterization of HCoV-EMC suggests that this virus is different from severe acute respiratory syndrome coronavirus (SARS-CoV) because it is able to replicate in multiple mammalian cell lines and it does not use angiotensin-converting enzyme 2 as a receptor to achieve infection. Additional research is urgently needed to better understand the pathogenicity and tissue tropism of this virus in humans. In their recent study published in mBio, Kindler et al. shed some light on these important topics (E. Kindler, H. R. Jónsdóttir, M. Muth, O. J. Hamming, R. Hartmann, R. Rodriguez, R. Geffers, R. A. Fouchier, C. Drosten, M. A. Müller, R. Dijkman, and V. Thiel, mBio 4[1]:e00611-12, 2013). These authors report the use of differentiated pseudostratified human primary airway epithelial cells, an in vitro model with high physiological relevance to the human airway epithelium, to characterize the cellular tropism of HCoV-EMC. More importantly, the authors demonstrate the potential use of type I and type III interferons (IFNs) to control viral infection.
format	article
author	Renee W. Y. Chan Leo L. M. Poon
author_facet	Renee W. Y. Chan Leo L. M. Poon
author_sort	Renee W. Y. Chan
title	The Emergence of Human Coronavirus EMC: How Scared Should We Be?
title_short	The Emergence of Human Coronavirus EMC: How Scared Should We Be?
title_full	The Emergence of Human Coronavirus EMC: How Scared Should We Be?
title_fullStr	The Emergence of Human Coronavirus EMC: How Scared Should We Be?
title_full_unstemmed	The Emergence of Human Coronavirus EMC: How Scared Should We Be?
title_sort	emergence of human coronavirus emc: how scared should we be?
publisher	American Society for Microbiology
publishDate	2013
url	https://doaj.org/article/a43291164c4d4fbc84818c174c37918a
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The Emergence of Human Coronavirus EMC: How Scared Should We Be?

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