Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease

Dietary choline metabolites, such as trimethylamine N-oxide and betaine, have been associated with coronary artery disease (CAD). Here, Hartiala et al. identify two genetic loci for betaine levels on chromosomes 2q34 and 5q14.1 and find that the 2q34 locus was also associated with other pathway inte...

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Autores principales:	Jaana A. Hartiala, W. H. Wilson Tang, Zeneng Wang, Amanda L. Crow, Alexandre F. R. Stewart, Robert Roberts, Ruth McPherson, Jeanette Erdmann, Christina Willenborg, Stanley L. Hazen, Hooman Allayee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a43466011e9a467bab3474f2025c21a0
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spelling	oai:doaj.org-article:a43466011e9a467bab3474f2025c21a02021-12-02T16:57:29ZGenome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease10.1038/ncomms105582041-1723https://doaj.org/article/a43466011e9a467bab3474f2025c21a02016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10558https://doaj.org/toc/2041-1723Dietary choline metabolites, such as trimethylamine N-oxide and betaine, have been associated with coronary artery disease (CAD). Here, Hartiala et al. identify two genetic loci for betaine levels on chromosomes 2q34 and 5q14.1 and find that the 2q34 locus was also associated with other pathway intermediates, and decreased risk of CAD in women.Jaana A. HartialaW. H. Wilson TangZeneng WangAmanda L. CrowAlexandre F. R. StewartRobert RobertsRuth McPhersonJeanette ErdmannChristina WillenborgStanley L. HazenHooman AllayeeNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jaana A. Hartiala W. H. Wilson Tang Zeneng Wang Amanda L. Crow Alexandre F. R. Stewart Robert Roberts Ruth McPherson Jeanette Erdmann Christina Willenborg Stanley L. Hazen Hooman Allayee Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease
description	Dietary choline metabolites, such as trimethylamine N-oxide and betaine, have been associated with coronary artery disease (CAD). Here, Hartiala et al. identify two genetic loci for betaine levels on chromosomes 2q34 and 5q14.1 and find that the 2q34 locus was also associated with other pathway intermediates, and decreased risk of CAD in women.
format	article
author	Jaana A. Hartiala W. H. Wilson Tang Zeneng Wang Amanda L. Crow Alexandre F. R. Stewart Robert Roberts Ruth McPherson Jeanette Erdmann Christina Willenborg Stanley L. Hazen Hooman Allayee
author_facet	Jaana A. Hartiala W. H. Wilson Tang Zeneng Wang Amanda L. Crow Alexandre F. R. Stewart Robert Roberts Ruth McPherson Jeanette Erdmann Christina Willenborg Stanley L. Hazen Hooman Allayee
author_sort	Jaana A. Hartiala
title	Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease
title_short	Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease
title_full	Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease
title_fullStr	Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease
title_full_unstemmed	Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease
title_sort	genome-wide association study and targeted metabolomics identifies sex-specific association of cps1 with coronary artery disease
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/a43466011e9a467bab3474f2025c21a0
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Genome-wide association study and targeted metabolomics identifies sex-specific association of CPS1 with coronary artery disease

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