Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications

Mitochondrial dysfunction has been proven to play a critical role in the pathogenesis of cardiovascular diseases. The phenomenon of intercellular mitochondrial transfer has been discovered in the cardiovascular system. Studies have shown that cell-to-cell mitochondrial transfer plays an essential ro...

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Autores principales:	Jun Chen, Jinjie Zhong, Lin-lin Wang, Ying-ying Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cardiovascular disease mitochondria mitochondrial transfer mitochondrial transplantation tunneling nanotubes extracellular vesicles Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/a43529cd05964a74bf93745c4b7a6976
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spelling	oai:doaj.org-article:a43529cd05964a74bf93745c4b7a69762021-12-01T05:48:01ZMitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications2297-055X10.3389/fcvm.2021.771298https://doaj.org/article/a43529cd05964a74bf93745c4b7a69762021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.771298/fullhttps://doaj.org/toc/2297-055XMitochondrial dysfunction has been proven to play a critical role in the pathogenesis of cardiovascular diseases. The phenomenon of intercellular mitochondrial transfer has been discovered in the cardiovascular system. Studies have shown that cell-to-cell mitochondrial transfer plays an essential role in regulating cardiovascular system development and maintaining normal tissue homeostasis under physiological conditions. In pathological conditions, damaged cells transfer dysfunctional mitochondria toward recipient cells to ask for help and take up exogenous functional mitochondria to alleviate injury. In this review, we summarized the mechanism of mitochondrial transfer in the cardiovascular system and outlined the fate and functional role of donor mitochondria. We also discussed the advantage and challenges of mitochondrial transfer strategies, including cell-based mitochondrial transplantation, extracellular vesicle-based mitochondrial transplantation, and naked mitochondrial transplantation, for the treatment of cardiovascular disorders. We hope this review will provide perspectives on mitochondrial-targeted therapeutics in cardiovascular diseases.Jun ChenJinjie ZhongLin-lin WangYing-ying ChenFrontiers Media S.A.articlecardiovascular diseasemitochondriamitochondrial transfermitochondrial transplantationtunneling nanotubesextracellular vesiclesDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular disease mitochondria mitochondrial transfer mitochondrial transplantation tunneling nanotubes extracellular vesicles Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	cardiovascular disease mitochondria mitochondrial transfer mitochondrial transplantation tunneling nanotubes extracellular vesicles Diseases of the circulatory (Cardiovascular) system RC666-701 Jun Chen Jinjie Zhong Lin-lin Wang Ying-ying Chen Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications
description	Mitochondrial dysfunction has been proven to play a critical role in the pathogenesis of cardiovascular diseases. The phenomenon of intercellular mitochondrial transfer has been discovered in the cardiovascular system. Studies have shown that cell-to-cell mitochondrial transfer plays an essential role in regulating cardiovascular system development and maintaining normal tissue homeostasis under physiological conditions. In pathological conditions, damaged cells transfer dysfunctional mitochondria toward recipient cells to ask for help and take up exogenous functional mitochondria to alleviate injury. In this review, we summarized the mechanism of mitochondrial transfer in the cardiovascular system and outlined the fate and functional role of donor mitochondria. We also discussed the advantage and challenges of mitochondrial transfer strategies, including cell-based mitochondrial transplantation, extracellular vesicle-based mitochondrial transplantation, and naked mitochondrial transplantation, for the treatment of cardiovascular disorders. We hope this review will provide perspectives on mitochondrial-targeted therapeutics in cardiovascular diseases.
format	article
author	Jun Chen Jinjie Zhong Lin-lin Wang Ying-ying Chen
author_facet	Jun Chen Jinjie Zhong Lin-lin Wang Ying-ying Chen
author_sort	Jun Chen
title	Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications
title_short	Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications
title_full	Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications
title_fullStr	Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications
title_full_unstemmed	Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications
title_sort	mitochondrial transfer in cardiovascular disease: from mechanisms to therapeutic implications
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/a43529cd05964a74bf93745c4b7a6976
work_keys_str_mv	AT junchen mitochondrialtransferincardiovasculardiseasefrommechanismstotherapeuticimplications AT jinjiezhong mitochondrialtransferincardiovasculardiseasefrommechanismstotherapeuticimplications AT linlinwang mitochondrialtransferincardiovasculardiseasefrommechanismstotherapeuticimplications AT yingyingchen mitochondrialtransferincardiovasculardiseasefrommechanismstotherapeuticimplications
_version_	1718405496208097280

Mitochondrial Transfer in Cardiovascular Disease: From Mechanisms to Therapeutic Implications

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