Applications for Induced Pluripotent Stem Cells in Disease Modelling and Drug Development for Heart Diseases

Induced pluripotent stem cells (iPSCs) are derived from reprogrammed somatic cells by the introduction of defined transcription factors. They are characterised by a capacity for self-renewal and pluripotency. Human (h)iPSCs are expected to be used extensively for disease modelling, drug screening an...

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Autores principales:	Shu Nakao, Dai Ihara, Koji Hasegawa, Teruhisa Kawamura
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2020
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/a4356f951c42478085d04105768d19b4
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spelling	oai:doaj.org-article:a4356f951c42478085d04105768d19b42021-12-04T16:02:27ZApplications for Induced Pluripotent Stem Cells in Disease Modelling and Drug Development for Heart Diseases10.15420/ecr.2019.031758-37641758-3756https://doaj.org/article/a4356f951c42478085d04105768d19b42020-02-01T00:00:00Zhttps://www.ecrjournal.com/articleindex/ecr.2019.03https://doaj.org/toc/1758-3756https://doaj.org/toc/1758-3764Induced pluripotent stem cells (iPSCs) are derived from reprogrammed somatic cells by the introduction of defined transcription factors. They are characterised by a capacity for self-renewal and pluripotency. Human (h)iPSCs are expected to be used extensively for disease modelling, drug screening and regenerative medicine. Obtaining cardiac tissue from patients with mutations for genetic studies and functional analyses is a highly invasive procedure. In contrast, disease-specific hiPSCs are derived from the somatic cells of patients with specific genetic mutations responsible for disease phenotypes. These disease-specific hiPSCs are a better tool for studies of the pathophysiology and cellular responses to therapeutic agents. This article focuses on the current understanding, limitations and future direction of disease-specific hiPSC-derived cardiomyocytes for further applications.Shu NakaoDai IharaKoji HasegawaTeruhisa KawamuraRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENEuropean Cardiology Review , Vol 15, Iss , Pp - (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Shu Nakao Dai Ihara Koji Hasegawa Teruhisa Kawamura Applications for Induced Pluripotent Stem Cells in Disease Modelling and Drug Development for Heart Diseases
description	Induced pluripotent stem cells (iPSCs) are derived from reprogrammed somatic cells by the introduction of defined transcription factors. They are characterised by a capacity for self-renewal and pluripotency. Human (h)iPSCs are expected to be used extensively for disease modelling, drug screening and regenerative medicine. Obtaining cardiac tissue from patients with mutations for genetic studies and functional analyses is a highly invasive procedure. In contrast, disease-specific hiPSCs are derived from the somatic cells of patients with specific genetic mutations responsible for disease phenotypes. These disease-specific hiPSCs are a better tool for studies of the pathophysiology and cellular responses to therapeutic agents. This article focuses on the current understanding, limitations and future direction of disease-specific hiPSC-derived cardiomyocytes for further applications.
format	article
author	Shu Nakao Dai Ihara Koji Hasegawa Teruhisa Kawamura
author_facet	Shu Nakao Dai Ihara Koji Hasegawa Teruhisa Kawamura
author_sort	Shu Nakao
title	Applications for Induced Pluripotent Stem Cells in Disease Modelling and Drug Development for Heart Diseases
title_short	Applications for Induced Pluripotent Stem Cells in Disease Modelling and Drug Development for Heart Diseases
title_full	Applications for Induced Pluripotent Stem Cells in Disease Modelling and Drug Development for Heart Diseases
title_fullStr	Applications for Induced Pluripotent Stem Cells in Disease Modelling and Drug Development for Heart Diseases
title_full_unstemmed	Applications for Induced Pluripotent Stem Cells in Disease Modelling and Drug Development for Heart Diseases
title_sort	applications for induced pluripotent stem cells in disease modelling and drug development for heart diseases
publisher	Radcliffe Medical Media
publishDate	2020
url	https://doaj.org/article/a4356f951c42478085d04105768d19b4
work_keys_str_mv	AT shunakao applicationsforinducedpluripotentstemcellsindiseasemodellinganddrugdevelopmentforheartdiseases AT daiihara applicationsforinducedpluripotentstemcellsindiseasemodellinganddrugdevelopmentforheartdiseases AT kojihasegawa applicationsforinducedpluripotentstemcellsindiseasemodellinganddrugdevelopmentforheartdiseases AT teruhisakawamura applicationsforinducedpluripotentstemcellsindiseasemodellinganddrugdevelopmentforheartdiseases
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Applications for Induced Pluripotent Stem Cells in Disease Modelling and Drug Development for Heart Diseases

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