Regulation of transforming growth factor-β signalling by SUMOylation and its role in fibrosis

Fibrosis is an abnormal healing process that only repairs the structure of an organ after injury and does not address damaged functions. The pathogenesis of fibrosis is multifactorial and highly complex; numerous signalling pathways are involved in this process, with the transforming growth factor-β...

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Autores principales:	Xinyi Wang, Ting Liu, Yifei Huang, Yifeng Dai, Hui Lin
Formato:	article
Lenguaje:	EN
Publicado:	The Royal Society 2021
Materias:	transforming growth factor-β SUMOylation fibrosis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a435da304d0f48979356daf89ce3e8ef
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spelling	oai:doaj.org-article:a435da304d0f48979356daf89ce3e8ef2021-11-12T09:28:26ZRegulation of transforming growth factor-β signalling by SUMOylation and its role in fibrosis10.1098/rsob.2100432046-2441https://doaj.org/article/a435da304d0f48979356daf89ce3e8ef2021-11-01T00:00:00Zhttps://royalsocietypublishing.org/doi/10.1098/rsob.210043https://doaj.org/toc/2046-2441Fibrosis is an abnormal healing process that only repairs the structure of an organ after injury and does not address damaged functions. The pathogenesis of fibrosis is multifactorial and highly complex; numerous signalling pathways are involved in this process, with the transforming growth factor-β (TGF-β) signalling pathway playing a central role. TGF-β regulates the generation of myofibroblasts and the epithelial–mesenchymal transition by regulating transcription and translation of downstream genes and precisely regulating fibrogenesis. The TGF-β signalling pathway can be modulated by various post-translational modifications, of which SUMOylation has been shown to play a key role. In this review, we focus on the function of SUMOylation in canonical and non-canonical TGF-β signalling and its role in fibrosis, providing promising therapeutic strategies for fibrosis.Xinyi WangTing LiuYifei HuangYifeng DaiHui LinThe Royal Societyarticletransforming growth factor-βSUMOylationfibrosisBiology (General)QH301-705.5ENOpen Biology, Vol 11, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	transforming growth factor-β SUMOylation fibrosis Biology (General) QH301-705.5
spellingShingle	transforming growth factor-β SUMOylation fibrosis Biology (General) QH301-705.5 Xinyi Wang Ting Liu Yifei Huang Yifeng Dai Hui Lin Regulation of transforming growth factor-β signalling by SUMOylation and its role in fibrosis
description	Fibrosis is an abnormal healing process that only repairs the structure of an organ after injury and does not address damaged functions. The pathogenesis of fibrosis is multifactorial and highly complex; numerous signalling pathways are involved in this process, with the transforming growth factor-β (TGF-β) signalling pathway playing a central role. TGF-β regulates the generation of myofibroblasts and the epithelial–mesenchymal transition by regulating transcription and translation of downstream genes and precisely regulating fibrogenesis. The TGF-β signalling pathway can be modulated by various post-translational modifications, of which SUMOylation has been shown to play a key role. In this review, we focus on the function of SUMOylation in canonical and non-canonical TGF-β signalling and its role in fibrosis, providing promising therapeutic strategies for fibrosis.
format	article
author	Xinyi Wang Ting Liu Yifei Huang Yifeng Dai Hui Lin
author_facet	Xinyi Wang Ting Liu Yifei Huang Yifeng Dai Hui Lin
author_sort	Xinyi Wang
title	Regulation of transforming growth factor-β signalling by SUMOylation and its role in fibrosis
title_short	Regulation of transforming growth factor-β signalling by SUMOylation and its role in fibrosis
title_full	Regulation of transforming growth factor-β signalling by SUMOylation and its role in fibrosis
title_fullStr	Regulation of transforming growth factor-β signalling by SUMOylation and its role in fibrosis
title_full_unstemmed	Regulation of transforming growth factor-β signalling by SUMOylation and its role in fibrosis
title_sort	regulation of transforming growth factor-β signalling by sumoylation and its role in fibrosis
publisher	The Royal Society
publishDate	2021
url	https://doaj.org/article/a435da304d0f48979356daf89ce3e8ef
work_keys_str_mv	AT xinyiwang regulationoftransforminggrowthfactorbsignallingbysumoylationanditsroleinfibrosis AT tingliu regulationoftransforminggrowthfactorbsignallingbysumoylationanditsroleinfibrosis AT yifeihuang regulationoftransforminggrowthfactorbsignallingbysumoylationanditsroleinfibrosis AT yifengdai regulationoftransforminggrowthfactorbsignallingbysumoylationanditsroleinfibrosis AT huilin regulationoftransforminggrowthfactorbsignallingbysumoylationanditsroleinfibrosis
_version_	1718431068747464704

Regulation of transforming growth factor-β signalling by SUMOylation and its role in fibrosis

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