Immunological Targets of Biologic Drugs in Allergic Skin Diseases in Children

Atopic dermatitis and urticaria are two invalidating skin disorders that are very common in children. Recent advances in the understanding of their specific intracellular molecular pathways have permitted the development of precise biological molecules, targeting inflammatory mediators and arresting...

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Autores principales:	Paola Di Filippo, Daniele Russo, Marina Attanasi, Sabrina Di Pillo, Francesco Chiarelli
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	atopic dermatitis chronic urticaria children biologics molecular pathways IgE Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/a436256ab94e4fc586001026c3d6a310
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spelling	oai:doaj.org-article:a436256ab94e4fc586001026c3d6a3102021-11-25T16:49:38ZImmunological Targets of Biologic Drugs in Allergic Skin Diseases in Children10.3390/biomedicines91116152227-9059https://doaj.org/article/a436256ab94e4fc586001026c3d6a3102021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1615https://doaj.org/toc/2227-9059Atopic dermatitis and urticaria are two invalidating skin disorders that are very common in children. Recent advances in the understanding of their specific intracellular molecular pathways have permitted the development of precise biological molecules, targeting inflammatory mediators and arresting the pathogenetic pathways of skin diseases. Many biologics with promising results have been studied, although few are currently approved in children. In this review, we aim to provide the latest evidence about the use, indications, efficacy and safety of biologic therapies to treat atopic dermatitis and chronic urticaria in children and adolescents.Paola Di FilippoDaniele RussoMarina AttanasiSabrina Di PilloFrancesco ChiarelliMDPI AGarticleatopic dermatitischronic urticariachildrenbiologicsmolecular pathwaysIgEBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1615, p 1615 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	atopic dermatitis chronic urticaria children biologics molecular pathways IgE Biology (General) QH301-705.5
spellingShingle	atopic dermatitis chronic urticaria children biologics molecular pathways IgE Biology (General) QH301-705.5 Paola Di Filippo Daniele Russo Marina Attanasi Sabrina Di Pillo Francesco Chiarelli Immunological Targets of Biologic Drugs in Allergic Skin Diseases in Children
description	Atopic dermatitis and urticaria are two invalidating skin disorders that are very common in children. Recent advances in the understanding of their specific intracellular molecular pathways have permitted the development of precise biological molecules, targeting inflammatory mediators and arresting the pathogenetic pathways of skin diseases. Many biologics with promising results have been studied, although few are currently approved in children. In this review, we aim to provide the latest evidence about the use, indications, efficacy and safety of biologic therapies to treat atopic dermatitis and chronic urticaria in children and adolescents.
format	article
author	Paola Di Filippo Daniele Russo Marina Attanasi Sabrina Di Pillo Francesco Chiarelli
author_facet	Paola Di Filippo Daniele Russo Marina Attanasi Sabrina Di Pillo Francesco Chiarelli
author_sort	Paola Di Filippo
title	Immunological Targets of Biologic Drugs in Allergic Skin Diseases in Children
title_short	Immunological Targets of Biologic Drugs in Allergic Skin Diseases in Children
title_full	Immunological Targets of Biologic Drugs in Allergic Skin Diseases in Children
title_fullStr	Immunological Targets of Biologic Drugs in Allergic Skin Diseases in Children
title_full_unstemmed	Immunological Targets of Biologic Drugs in Allergic Skin Diseases in Children
title_sort	immunological targets of biologic drugs in allergic skin diseases in children
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/a436256ab94e4fc586001026c3d6a310
work_keys_str_mv	AT paoladifilippo immunologicaltargetsofbiologicdrugsinallergicskindiseasesinchildren AT danielerusso immunologicaltargetsofbiologicdrugsinallergicskindiseasesinchildren AT marinaattanasi immunologicaltargetsofbiologicdrugsinallergicskindiseasesinchildren AT sabrinadipillo immunologicaltargetsofbiologicdrugsinallergicskindiseasesinchildren AT francescochiarelli immunologicaltargetsofbiologicdrugsinallergicskindiseasesinchildren
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Immunological Targets of Biologic Drugs in Allergic Skin Diseases in Children

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