Prognostic factors of restrictive myopathy in thyroid eye disease

Abstract To investigate the prognostic factors of extraocular muscle restriction in patients with thyroid eye disease (TED), 65 patients with TED and restrictive myopathy were evaluated. Demographics, clinical activity score (CAS), smoking status, thyroid disease status, thyroid hormone status, thyr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jae Hwan Choi, Hoon Noh, Yoon-Duck Kim, Kyung In Woo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a4368f63ac6b4d7a8daf9c326cf9b5cb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:a4368f63ac6b4d7a8daf9c326cf9b5cb
record_format	dspace
spelling	oai:doaj.org-article:a4368f63ac6b4d7a8daf9c326cf9b5cb2021-12-02T16:10:24ZPrognostic factors of restrictive myopathy in thyroid eye disease10.1038/s41598-021-93275-92045-2322https://doaj.org/article/a4368f63ac6b4d7a8daf9c326cf9b5cb2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93275-9https://doaj.org/toc/2045-2322Abstract To investigate the prognostic factors of extraocular muscle restriction in patients with thyroid eye disease (TED), 65 patients with TED and restrictive myopathy were evaluated. Demographics, clinical activity score (CAS), smoking status, thyroid disease status, thyroid hormone status, thyroid autoantibody status, orbital computed tomography (CT) scan at initial presentation, and treatment regimens were assessed. The movements of the most severely affected extraocular muscles were categorized into five grades. The patients were divided into the improved and the not-improved group based on the improvement in the limitation of the extraocular muscle excursion (LOM) throughout the follow-up, and the groups were compared using clinical factors. The mean LOM significantly improved from 2.3 ± 1.1 to 1.7 ± 1.2 after 1 year of follow-up. The excursion of the most restricted muscle improved in 32 patients but not in 33 patients during the follow-up. The initial concentration of the thyroid-stimulating antibody (TSAb) was significantly lower in the improved (229.3 ± 114.1) than in the not-improved group (345.0 ± 178.6) (P = 0.02) Age, sex, smoking status, CAS, thyroid status, and muscle thickness on the CT scan did not significantly differ in the groups. This study showed that the initial concentration of TSAb is a factor affecting the recovery of restrictive myopathy.Jae Hwan ChoiHoon NohYoon-Duck KimKyung In WooNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jae Hwan Choi Hoon Noh Yoon-Duck Kim Kyung In Woo Prognostic factors of restrictive myopathy in thyroid eye disease
description	Abstract To investigate the prognostic factors of extraocular muscle restriction in patients with thyroid eye disease (TED), 65 patients with TED and restrictive myopathy were evaluated. Demographics, clinical activity score (CAS), smoking status, thyroid disease status, thyroid hormone status, thyroid autoantibody status, orbital computed tomography (CT) scan at initial presentation, and treatment regimens were assessed. The movements of the most severely affected extraocular muscles were categorized into five grades. The patients were divided into the improved and the not-improved group based on the improvement in the limitation of the extraocular muscle excursion (LOM) throughout the follow-up, and the groups were compared using clinical factors. The mean LOM significantly improved from 2.3 ± 1.1 to 1.7 ± 1.2 after 1 year of follow-up. The excursion of the most restricted muscle improved in 32 patients but not in 33 patients during the follow-up. The initial concentration of the thyroid-stimulating antibody (TSAb) was significantly lower in the improved (229.3 ± 114.1) than in the not-improved group (345.0 ± 178.6) (P = 0.02) Age, sex, smoking status, CAS, thyroid status, and muscle thickness on the CT scan did not significantly differ in the groups. This study showed that the initial concentration of TSAb is a factor affecting the recovery of restrictive myopathy.
format	article
author	Jae Hwan Choi Hoon Noh Yoon-Duck Kim Kyung In Woo
author_facet	Jae Hwan Choi Hoon Noh Yoon-Duck Kim Kyung In Woo
author_sort	Jae Hwan Choi
title	Prognostic factors of restrictive myopathy in thyroid eye disease
title_short	Prognostic factors of restrictive myopathy in thyroid eye disease
title_full	Prognostic factors of restrictive myopathy in thyroid eye disease
title_fullStr	Prognostic factors of restrictive myopathy in thyroid eye disease
title_full_unstemmed	Prognostic factors of restrictive myopathy in thyroid eye disease
title_sort	prognostic factors of restrictive myopathy in thyroid eye disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a4368f63ac6b4d7a8daf9c326cf9b5cb
work_keys_str_mv	AT jaehwanchoi prognosticfactorsofrestrictivemyopathyinthyroideyedisease AT hoonnoh prognosticfactorsofrestrictivemyopathyinthyroideyedisease AT yoonduckkim prognosticfactorsofrestrictivemyopathyinthyroideyedisease AT kyunginwoo prognosticfactorsofrestrictivemyopathyinthyroideyedisease
_version_	1718384429393510400

Prognostic factors of restrictive myopathy in thyroid eye disease

Ejemplares similares