Novel moisturized and antimicrobial hand gel based on zinc-aminoclay and Opuntia humifusa extract

Abstract The high antimicrobial ability and low toxicity of zinc-aminoclay (ZnAC) are claimed in our previous reports. In this study, we formulate a novel hand gel based on ZnAC and Opuntia humifusa (O. humifusa) extract, which is a high moisturizing agent. The antimicrobial activity, cytotoxicity,...

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Autores principales:	Hien Thi Hoang, Vinh Van Tran, Vu Khac Hoang Bui, Oh-Hyeok Kwon, Ju-Young Moon, Young-Chul Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a43b4402ebe64ac6877db5cf7700d017
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spelling	oai:doaj.org-article:a43b4402ebe64ac6877db5cf7700d0172021-12-02T17:19:16ZNovel moisturized and antimicrobial hand gel based on zinc-aminoclay and Opuntia humifusa extract10.1038/s41598-021-97363-82045-2322https://doaj.org/article/a43b4402ebe64ac6877db5cf7700d0172021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97363-8https://doaj.org/toc/2045-2322Abstract The high antimicrobial ability and low toxicity of zinc-aminoclay (ZnAC) are claimed in our previous reports. In this study, we formulate a novel hand gel based on ZnAC and Opuntia humifusa (O. humifusa) extract, which is a high moisturizing agent. The antimicrobial activity, cytotoxicity, moisturizing effect, and clinical skin irritation of the hand gel are evaluated. The hand gel with 0.5 wt.% ZnAC and 1.0 v/v% O. humifusa extract can kill more than 99% Escherichia coli (gram-negative bacteria) and Staphylococcus aureus (gram-positive bacteria) after 24 h. Toxicity evaluation shows that, the hand gel does not affect the viability of mammalian HaCaT cells. Additionally, skin moisture is increased by applying the hand gel while its viscosity is at the standard level of commercial products. The hand gel has a skin irritation index of 0.0 and is classified as a non-irritating product. We successfully formulated hand gel from ZnAC, glucomannan, glycerol, and O. humifusa extract. Owing to the high antimicrobial activity and skin protection of hand gels, they are suitable to be used as hand sanitizers in restaurants, hospitals, and homes effectively.Hien Thi HoangVinh Van TranVu Khac Hoang BuiOh-Hyeok KwonJu-Young MoonYoung-Chul LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hien Thi Hoang Vinh Van Tran Vu Khac Hoang Bui Oh-Hyeok Kwon Ju-Young Moon Young-Chul Lee Novel moisturized and antimicrobial hand gel based on zinc-aminoclay and Opuntia humifusa extract
description	Abstract The high antimicrobial ability and low toxicity of zinc-aminoclay (ZnAC) are claimed in our previous reports. In this study, we formulate a novel hand gel based on ZnAC and Opuntia humifusa (O. humifusa) extract, which is a high moisturizing agent. The antimicrobial activity, cytotoxicity, moisturizing effect, and clinical skin irritation of the hand gel are evaluated. The hand gel with 0.5 wt.% ZnAC and 1.0 v/v% O. humifusa extract can kill more than 99% Escherichia coli (gram-negative bacteria) and Staphylococcus aureus (gram-positive bacteria) after 24 h. Toxicity evaluation shows that, the hand gel does not affect the viability of mammalian HaCaT cells. Additionally, skin moisture is increased by applying the hand gel while its viscosity is at the standard level of commercial products. The hand gel has a skin irritation index of 0.0 and is classified as a non-irritating product. We successfully formulated hand gel from ZnAC, glucomannan, glycerol, and O. humifusa extract. Owing to the high antimicrobial activity and skin protection of hand gels, they are suitable to be used as hand sanitizers in restaurants, hospitals, and homes effectively.
format	article
author	Hien Thi Hoang Vinh Van Tran Vu Khac Hoang Bui Oh-Hyeok Kwon Ju-Young Moon Young-Chul Lee
author_facet	Hien Thi Hoang Vinh Van Tran Vu Khac Hoang Bui Oh-Hyeok Kwon Ju-Young Moon Young-Chul Lee
author_sort	Hien Thi Hoang
title	Novel moisturized and antimicrobial hand gel based on zinc-aminoclay and Opuntia humifusa extract
title_short	Novel moisturized and antimicrobial hand gel based on zinc-aminoclay and Opuntia humifusa extract
title_full	Novel moisturized and antimicrobial hand gel based on zinc-aminoclay and Opuntia humifusa extract
title_fullStr	Novel moisturized and antimicrobial hand gel based on zinc-aminoclay and Opuntia humifusa extract
title_full_unstemmed	Novel moisturized and antimicrobial hand gel based on zinc-aminoclay and Opuntia humifusa extract
title_sort	novel moisturized and antimicrobial hand gel based on zinc-aminoclay and opuntia humifusa extract
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a43b4402ebe64ac6877db5cf7700d017
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Novel moisturized and antimicrobial hand gel based on zinc-aminoclay and Opuntia humifusa extract

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