Role of androgens, progestins and tibolone in the treatment of menopausal symptoms: a review of the clinical evidence

Maria Garefalakis, Martha HickeySchool of Women’s and Infants’ Health, The University of Western Australia, King Edward Memorial Hospital, Subiaco, Western Australia, AustraliaAbstract: Estrogen-containing hormone therapy (HT) is the most widely prescribed and wellestablished tre...

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Autores principales:	Maria Garefalakis, Martha Hickey
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/a43e269b3c01492392c5d8c1f50a31ec
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spelling	oai:doaj.org-article:a43e269b3c01492392c5d8c1f50a31ec2021-12-02T00:52:36ZRole of androgens, progestins and tibolone in the treatment of menopausal symptoms: a review of the clinical evidence1178-1998https://doaj.org/article/a43e269b3c01492392c5d8c1f50a31ec2008-03-01T00:00:00Zhttps://www.dovepress.com/role-of-androgens-progestins-and-tibolone-in-the-treatment-of-menopaus-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Maria Garefalakis, Martha HickeySchool of Women’s and Infants’ Health, The University of Western Australia, King Edward Memorial Hospital, Subiaco, Western Australia, AustraliaAbstract: Estrogen-containing hormone therapy (HT) is the most widely prescribed and wellestablished treatment for menopausal symptoms. High quality evidence confirms that estrogen effectively treats hot flushes, night sweats and vaginal dryness. Progestins are combined with estrogen to prevent endometrial hyperplasia and are sometimes used alone for hot flushes, but are less effective than estrogen for this purpose. Data are conflicting regarding the role of androgens for improving libido and well-being. The synthetic steroid tibolone is widely used in Europe and Australasia and effectively treats hot flushes and vaginal dryness. Tibolone may improve libido more effectively than estrogen containing HT in some women. We summarize the data from studies addressing the efficacy, benefits, and risks of androgens, progestins and tibolone in the treatment of menopausal symptoms.Keywords: androgens, testosterone, progestins, tibolone, menopause, therapeuticMaria GarefalakisMartha HickeyDove Medical PressarticleGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 3, Pp 1-8 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Maria Garefalakis Martha Hickey Role of androgens, progestins and tibolone in the treatment of menopausal symptoms: a review of the clinical evidence
description	Maria Garefalakis, Martha HickeySchool of Women’s and Infants’ Health, The University of Western Australia, King Edward Memorial Hospital, Subiaco, Western Australia, AustraliaAbstract: Estrogen-containing hormone therapy (HT) is the most widely prescribed and wellestablished treatment for menopausal symptoms. High quality evidence confirms that estrogen effectively treats hot flushes, night sweats and vaginal dryness. Progestins are combined with estrogen to prevent endometrial hyperplasia and are sometimes used alone for hot flushes, but are less effective than estrogen for this purpose. Data are conflicting regarding the role of androgens for improving libido and well-being. The synthetic steroid tibolone is widely used in Europe and Australasia and effectively treats hot flushes and vaginal dryness. Tibolone may improve libido more effectively than estrogen containing HT in some women. We summarize the data from studies addressing the efficacy, benefits, and risks of androgens, progestins and tibolone in the treatment of menopausal symptoms.Keywords: androgens, testosterone, progestins, tibolone, menopause, therapeutic
format	article
author	Maria Garefalakis Martha Hickey
author_facet	Maria Garefalakis Martha Hickey
author_sort	Maria Garefalakis
title	Role of androgens, progestins and tibolone in the treatment of menopausal symptoms: a review of the clinical evidence
title_short	Role of androgens, progestins and tibolone in the treatment of menopausal symptoms: a review of the clinical evidence
title_full	Role of androgens, progestins and tibolone in the treatment of menopausal symptoms: a review of the clinical evidence
title_fullStr	Role of androgens, progestins and tibolone in the treatment of menopausal symptoms: a review of the clinical evidence
title_full_unstemmed	Role of androgens, progestins and tibolone in the treatment of menopausal symptoms: a review of the clinical evidence
title_sort	role of androgens, progestins and tibolone in the treatment of menopausal symptoms: a review of the clinical evidence
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/a43e269b3c01492392c5d8c1f50a31ec
work_keys_str_mv	AT mariagarefalakis roleofandrogensprogestinsandtiboloneinthetreatmentofmenopausalsymptomsareviewoftheclinicalevidence AT marthahickey roleofandrogensprogestinsandtiboloneinthetreatmentofmenopausalsymptomsareviewoftheclinicalevidence
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Role of androgens, progestins and tibolone in the treatment of menopausal symptoms: a review of the clinical evidence

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