Recent advances on smart TiO2 nanotube platforms for sustainable drug delivery applications
Qun Wang,1,2,* Jian-Ying Huang,2,* Hua-Qiong Li,3,4 Allan Zi-Jian Zhao,4 Yi Wang,4 Ke-Qin Zhang,2,5 Hong-Tao Sun,1 Yue-Kun Lai,2,5 1College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 2National Engineering Laboratory for Modern Silk, College of Textile and...
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Dove Medical Press
2016
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oai:doaj.org-article:a43ebd22cdb24e9ab4ee65484695e0162021-12-02T07:36:57ZRecent advances on smart TiO2 nanotube platforms for sustainable drug delivery applications1178-2013https://doaj.org/article/a43ebd22cdb24e9ab4ee65484695e0162016-12-01T00:00:00Zhttps://www.dovepress.com/recent--advances-on-smart-tio2-nanotube-platforms-for-sustainable-drug-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Qun Wang,1,2,* Jian-Ying Huang,2,* Hua-Qiong Li,3,4 Allan Zi-Jian Zhao,4 Yi Wang,4 Ke-Qin Zhang,2,5 Hong-Tao Sun,1 Yue-Kun Lai,2,5 1College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 2National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, 3Institute of Biomaterials and Engineering, Wenzhou Medical University, 4Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou, 5Research Center of Cooperative Innovation for Functional Organic/Polymer Material Micro/Nanofabrication, Suzhou, People’s Republic of China *These authors contributed equally to this work Abstract: To address the limitations of traditional drug delivery, TiO2 nanotubes (TNTs) are recognized as a promising material for localized drug delivery systems. With regard to the excellent biocompatibility and physicochemical properties, TNTs prepared by a facile electrochemical anodizing process have been used to fabricate new drug-releasing implants for localized drug delivery. This review discusses the development of TNTs applied in localized drug delivery systems, focusing on several approaches to control drug release, including the regulation of the dimensions of TNTs, modification of internal chemical characteristics, adjusting pore openings by biopolymer coatings, and employing polymeric micelles as drug nanocarriers. Furthermore, rational strategies on external conditions-triggered stimuli-responsive drug release for localized drug delivery systems are highlighted. Finally, the review concludes with the recent advances on TNTs for controlled drug delivery and corresponding prospects in the future. Keywords: TiO2 nanotubes, electrochemical anodization, modification, stimulated drug delivery, drug-releasing implantWang QHuang JYLi HQZhao AZWang YZhang KQSun HTLai YKDove Medical PressarticleTiO2 nanotubeselectrochemical anodizationdrug deliverydrug-releasing implantsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 151-165 (2016) |
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DOAJ |
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EN |
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TiO2 nanotubes electrochemical anodization drug delivery drug-releasing implants Medicine (General) R5-920 |
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TiO2 nanotubes electrochemical anodization drug delivery drug-releasing implants Medicine (General) R5-920 Wang Q Huang JY Li HQ Zhao AZ Wang Y Zhang KQ Sun HT Lai YK Recent advances on smart TiO2 nanotube platforms for sustainable drug delivery applications |
| description |
Qun Wang,1,2,* Jian-Ying Huang,2,* Hua-Qiong Li,3,4 Allan Zi-Jian Zhao,4 Yi Wang,4 Ke-Qin Zhang,2,5 Hong-Tao Sun,1 Yue-Kun Lai,2,5 1College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 2National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, 3Institute of Biomaterials and Engineering, Wenzhou Medical University, 4Wenzhou Institute of Biomaterials and Engineering, Chinese Academy of Sciences, Wenzhou, 5Research Center of Cooperative Innovation for Functional Organic/Polymer Material Micro/Nanofabrication, Suzhou, People’s Republic of China *These authors contributed equally to this work Abstract: To address the limitations of traditional drug delivery, TiO2 nanotubes (TNTs) are recognized as a promising material for localized drug delivery systems. With regard to the excellent biocompatibility and physicochemical properties, TNTs prepared by a facile electrochemical anodizing process have been used to fabricate new drug-releasing implants for localized drug delivery. This review discusses the development of TNTs applied in localized drug delivery systems, focusing on several approaches to control drug release, including the regulation of the dimensions of TNTs, modification of internal chemical characteristics, adjusting pore openings by biopolymer coatings, and employing polymeric micelles as drug nanocarriers. Furthermore, rational strategies on external conditions-triggered stimuli-responsive drug release for localized drug delivery systems are highlighted. Finally, the review concludes with the recent advances on TNTs for controlled drug delivery and corresponding prospects in the future. Keywords: TiO2 nanotubes, electrochemical anodization, modification, stimulated drug delivery, drug-releasing implant |
| format |
article |
| author |
Wang Q Huang JY Li HQ Zhao AZ Wang Y Zhang KQ Sun HT Lai YK |
| author_facet |
Wang Q Huang JY Li HQ Zhao AZ Wang Y Zhang KQ Sun HT Lai YK |
| author_sort |
Wang Q |
| title |
Recent advances on smart TiO2 nanotube platforms for sustainable drug delivery applications |
| title_short |
Recent advances on smart TiO2 nanotube platforms for sustainable drug delivery applications |
| title_full |
Recent advances on smart TiO2 nanotube platforms for sustainable drug delivery applications |
| title_fullStr |
Recent advances on smart TiO2 nanotube platforms for sustainable drug delivery applications |
| title_full_unstemmed |
Recent advances on smart TiO2 nanotube platforms for sustainable drug delivery applications |
| title_sort |
recent advances on smart tio2 nanotube platforms for sustainable drug delivery applications |
| publisher |
Dove Medical Press |
| publishDate |
2016 |
| url |
https://doaj.org/article/a43ebd22cdb24e9ab4ee65484695e016 |
| work_keys_str_mv |
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