CT-derived 3D-diaphragm motion in emphysema and IPF compared to normal subjects

Abstract Image registration-based local displacement analysis enables evaluation of respiratory motion between two computed tomography-captured lung volumes. The objective of this study was to compare diaphragm movement among emphysema, idiopathic pulmonary fibrosis (IPF) and normal subjects. 29 nor...

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Autores principales:	Ji Hee Kang, Jiwoong Choi, Kum Ju Chae, Kyung Min Shin, Chang-Hoon Lee, Junfeng Guo, Ching-Long Lin, Eric A. Hoffman, Changhyun Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a43f9380dfd04264b072565ef5cc7d77
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spelling	oai:doaj.org-article:a43f9380dfd04264b072565ef5cc7d772021-12-02T17:03:49ZCT-derived 3D-diaphragm motion in emphysema and IPF compared to normal subjects10.1038/s41598-021-93980-52045-2322https://doaj.org/article/a43f9380dfd04264b072565ef5cc7d772021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93980-5https://doaj.org/toc/2045-2322Abstract Image registration-based local displacement analysis enables evaluation of respiratory motion between two computed tomography-captured lung volumes. The objective of this study was to compare diaphragm movement among emphysema, idiopathic pulmonary fibrosis (IPF) and normal subjects. 29 normal, 50 emphysema, and 51 IPF subjects were included. A mass preserving image registration technique was used to compute displacement vectors of local lung regions at an acinar scale. Movement of the diaphragm was assumed to be equivalent to movement of the basal lung within 5 mm from the diaphragm. Magnitudes and directions of displacement vectors were compared between the groups. Three-dimensional (3D) and apico-basal displacements were smaller in emphysema than normal subjects (P = 0.003, P = 0.002). Low lung attenuation area on expiration scan showed significant correlations with decreased 3D and apico-basal displacements (r = − 0.546, P < 0.0001; r = − 0.521, P < 0.0001) in emphysema patients. Dorsal–ventral displacement was smaller in IPF than normal subjects (P < 0.0001). The standard deviation of the displacement angle was greater in both emphysema and IPF patients than normal subjects (P < 0.0001). In conclusion, apico-basal movement of the diaphragm is reduced in emphysema while dorsal–ventral movement is reduced in IPF. Image registration technique to multi-volume CT scans provides insight into the pathophysiology of limited diaphragmatic motion in emphysema and IPF.Ji Hee KangJiwoong ChoiKum Ju ChaeKyung Min ShinChang-Hoon LeeJunfeng GuoChing-Long LinEric A. HoffmanChanghyun LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ji Hee Kang Jiwoong Choi Kum Ju Chae Kyung Min Shin Chang-Hoon Lee Junfeng Guo Ching-Long Lin Eric A. Hoffman Changhyun Lee CT-derived 3D-diaphragm motion in emphysema and IPF compared to normal subjects
description	Abstract Image registration-based local displacement analysis enables evaluation of respiratory motion between two computed tomography-captured lung volumes. The objective of this study was to compare diaphragm movement among emphysema, idiopathic pulmonary fibrosis (IPF) and normal subjects. 29 normal, 50 emphysema, and 51 IPF subjects were included. A mass preserving image registration technique was used to compute displacement vectors of local lung regions at an acinar scale. Movement of the diaphragm was assumed to be equivalent to movement of the basal lung within 5 mm from the diaphragm. Magnitudes and directions of displacement vectors were compared between the groups. Three-dimensional (3D) and apico-basal displacements were smaller in emphysema than normal subjects (P = 0.003, P = 0.002). Low lung attenuation area on expiration scan showed significant correlations with decreased 3D and apico-basal displacements (r = − 0.546, P < 0.0001; r = − 0.521, P < 0.0001) in emphysema patients. Dorsal–ventral displacement was smaller in IPF than normal subjects (P < 0.0001). The standard deviation of the displacement angle was greater in both emphysema and IPF patients than normal subjects (P < 0.0001). In conclusion, apico-basal movement of the diaphragm is reduced in emphysema while dorsal–ventral movement is reduced in IPF. Image registration technique to multi-volume CT scans provides insight into the pathophysiology of limited diaphragmatic motion in emphysema and IPF.
format	article
author	Ji Hee Kang Jiwoong Choi Kum Ju Chae Kyung Min Shin Chang-Hoon Lee Junfeng Guo Ching-Long Lin Eric A. Hoffman Changhyun Lee
author_facet	Ji Hee Kang Jiwoong Choi Kum Ju Chae Kyung Min Shin Chang-Hoon Lee Junfeng Guo Ching-Long Lin Eric A. Hoffman Changhyun Lee
author_sort	Ji Hee Kang
title	CT-derived 3D-diaphragm motion in emphysema and IPF compared to normal subjects
title_short	CT-derived 3D-diaphragm motion in emphysema and IPF compared to normal subjects
title_full	CT-derived 3D-diaphragm motion in emphysema and IPF compared to normal subjects
title_fullStr	CT-derived 3D-diaphragm motion in emphysema and IPF compared to normal subjects
title_full_unstemmed	CT-derived 3D-diaphragm motion in emphysema and IPF compared to normal subjects
title_sort	ct-derived 3d-diaphragm motion in emphysema and ipf compared to normal subjects
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a43f9380dfd04264b072565ef5cc7d77
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CT-derived 3D-diaphragm motion in emphysema and IPF compared to normal subjects

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