Genome-wide analysis yields new loci associating with aortic valve stenosis
Aortic valve stenosis (AS) is the most common valvular heart disease. Here the authors identify two new AS loci that also associate with bicuspid aortic valve, aortic root diameter and/or coronary artery disease implicating both developmental abnormalities and atherosclerosis-like processes in AS.
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Nature Portfolio
2018
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oai:doaj.org-article:a44005363a9e4871815257fb6639eafd2021-12-02T14:39:27ZGenome-wide analysis yields new loci associating with aortic valve stenosis10.1038/s41467-018-03252-62041-1723https://doaj.org/article/a44005363a9e4871815257fb6639eafd2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03252-6https://doaj.org/toc/2041-1723Aortic valve stenosis (AS) is the most common valvular heart disease. Here the authors identify two new AS loci that also associate with bicuspid aortic valve, aortic root diameter and/or coronary artery disease implicating both developmental abnormalities and atherosclerosis-like processes in AS.Anna HelgadottirGudmar ThorleifssonSolveig GretarsdottirOlafur A. StefanssonVinicius TraganteRosa B. ThorolfsdottirIngileif JonsdottirThorsteinn BjornssonValgerdur SteinthorsdottirNiek VerweijJonas B. NielsenWei ZhouLasse FolkersenAndreas MartinssonMahyar HeydarpourSiddharth PrakashGylfi OskarssonTomas GudbjartssonArnar GeirssonIsleifur OlafssonEmil L. SigurdssonPeter AlmgrenOlle MelanderAnders Franco-CerecedaAnders HamstenLars FritscheMaoxuan LinBo YangWhitney HornsbyDongchuan GuoChad M. BrummettGonçalo AbecasisMichael MathisDianna MilewiczSimon C. BodyPer ErikssonCristen J. WillerKristian HveemChristopher Newton-ChehJ. Gustav SmithRagnar DanielsenGudmundur ThorgeirssonUnnur ThorsteinsdottirDaniel F. GudbjartssonHilma HolmKari StefanssonNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Anna Helgadottir Gudmar Thorleifsson Solveig Gretarsdottir Olafur A. Stefansson Vinicius Tragante Rosa B. Thorolfsdottir Ingileif Jonsdottir Thorsteinn Bjornsson Valgerdur Steinthorsdottir Niek Verweij Jonas B. Nielsen Wei Zhou Lasse Folkersen Andreas Martinsson Mahyar Heydarpour Siddharth Prakash Gylfi Oskarsson Tomas Gudbjartsson Arnar Geirsson Isleifur Olafsson Emil L. Sigurdsson Peter Almgren Olle Melander Anders Franco-Cereceda Anders Hamsten Lars Fritsche Maoxuan Lin Bo Yang Whitney Hornsby Dongchuan Guo Chad M. Brummett Gonçalo Abecasis Michael Mathis Dianna Milewicz Simon C. Body Per Eriksson Cristen J. Willer Kristian Hveem Christopher Newton-Cheh J. Gustav Smith Ragnar Danielsen Gudmundur Thorgeirsson Unnur Thorsteinsdottir Daniel F. Gudbjartsson Hilma Holm Kari Stefansson Genome-wide analysis yields new loci associating with aortic valve stenosis |
| description |
Aortic valve stenosis (AS) is the most common valvular heart disease. Here the authors identify two new AS loci that also associate with bicuspid aortic valve, aortic root diameter and/or coronary artery disease implicating both developmental abnormalities and atherosclerosis-like processes in AS. |
| format |
article |
| author |
Anna Helgadottir Gudmar Thorleifsson Solveig Gretarsdottir Olafur A. Stefansson Vinicius Tragante Rosa B. Thorolfsdottir Ingileif Jonsdottir Thorsteinn Bjornsson Valgerdur Steinthorsdottir Niek Verweij Jonas B. Nielsen Wei Zhou Lasse Folkersen Andreas Martinsson Mahyar Heydarpour Siddharth Prakash Gylfi Oskarsson Tomas Gudbjartsson Arnar Geirsson Isleifur Olafsson Emil L. Sigurdsson Peter Almgren Olle Melander Anders Franco-Cereceda Anders Hamsten Lars Fritsche Maoxuan Lin Bo Yang Whitney Hornsby Dongchuan Guo Chad M. Brummett Gonçalo Abecasis Michael Mathis Dianna Milewicz Simon C. Body Per Eriksson Cristen J. Willer Kristian Hveem Christopher Newton-Cheh J. Gustav Smith Ragnar Danielsen Gudmundur Thorgeirsson Unnur Thorsteinsdottir Daniel F. Gudbjartsson Hilma Holm Kari Stefansson |
| author_facet |
Anna Helgadottir Gudmar Thorleifsson Solveig Gretarsdottir Olafur A. Stefansson Vinicius Tragante Rosa B. Thorolfsdottir Ingileif Jonsdottir Thorsteinn Bjornsson Valgerdur Steinthorsdottir Niek Verweij Jonas B. Nielsen Wei Zhou Lasse Folkersen Andreas Martinsson Mahyar Heydarpour Siddharth Prakash Gylfi Oskarsson Tomas Gudbjartsson Arnar Geirsson Isleifur Olafsson Emil L. Sigurdsson Peter Almgren Olle Melander Anders Franco-Cereceda Anders Hamsten Lars Fritsche Maoxuan Lin Bo Yang Whitney Hornsby Dongchuan Guo Chad M. Brummett Gonçalo Abecasis Michael Mathis Dianna Milewicz Simon C. Body Per Eriksson Cristen J. Willer Kristian Hveem Christopher Newton-Cheh J. Gustav Smith Ragnar Danielsen Gudmundur Thorgeirsson Unnur Thorsteinsdottir Daniel F. Gudbjartsson Hilma Holm Kari Stefansson |
| author_sort |
Anna Helgadottir |
| title |
Genome-wide analysis yields new loci associating with aortic valve stenosis |
| title_short |
Genome-wide analysis yields new loci associating with aortic valve stenosis |
| title_full |
Genome-wide analysis yields new loci associating with aortic valve stenosis |
| title_fullStr |
Genome-wide analysis yields new loci associating with aortic valve stenosis |
| title_full_unstemmed |
Genome-wide analysis yields new loci associating with aortic valve stenosis |
| title_sort |
genome-wide analysis yields new loci associating with aortic valve stenosis |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/a44005363a9e4871815257fb6639eafd |
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