Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma

Intratumoral CD8+ T cells commonly display a dysfunctional state, however it remains unclear whether tumor cell metabolism actively promotes T-cell exhaustion. Here, the authors show that the tumor methionine recycling pathway has a central role in promoting T-cell dysfunction in hepatocellular carc...

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Autores principales:	Man Hsin Hung, Joo Sang Lee, Chi Ma, Laurence P. Diggs, Sophia Heinrich, Ching Wen Chang, Lichun Ma, Marshonna Forgues, Anuradha Budhu, Jittiporn Chaisaingmongkol, Mathuros Ruchirawat, Eytan Ruppin, Tim F. Greten, Xin Wei Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/a4410c080725408d9c0d3f511de3fd95
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spelling	oai:doaj.org-article:a4410c080725408d9c0d3f511de3fd952021-12-02T15:52:56ZTumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma10.1038/s41467-021-21804-12041-1723https://doaj.org/article/a4410c080725408d9c0d3f511de3fd952021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21804-1https://doaj.org/toc/2041-1723Intratumoral CD8+ T cells commonly display a dysfunctional state, however it remains unclear whether tumor cell metabolism actively promotes T-cell exhaustion. Here, the authors show that the tumor methionine recycling pathway has a central role in promoting T-cell dysfunction in hepatocellular carcinoma, contributing to tumor immune evasion.Man Hsin HungJoo Sang LeeChi MaLaurence P. DiggsSophia HeinrichChing Wen ChangLichun MaMarshonna ForguesAnuradha BudhuJittiporn ChaisaingmongkolMathuros RuchirawatEytan RuppinTim F. GretenXin Wei WangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Man Hsin Hung Joo Sang Lee Chi Ma Laurence P. Diggs Sophia Heinrich Ching Wen Chang Lichun Ma Marshonna Forgues Anuradha Budhu Jittiporn Chaisaingmongkol Mathuros Ruchirawat Eytan Ruppin Tim F. Greten Xin Wei Wang Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma
description	Intratumoral CD8+ T cells commonly display a dysfunctional state, however it remains unclear whether tumor cell metabolism actively promotes T-cell exhaustion. Here, the authors show that the tumor methionine recycling pathway has a central role in promoting T-cell dysfunction in hepatocellular carcinoma, contributing to tumor immune evasion.
format	article
author	Man Hsin Hung Joo Sang Lee Chi Ma Laurence P. Diggs Sophia Heinrich Ching Wen Chang Lichun Ma Marshonna Forgues Anuradha Budhu Jittiporn Chaisaingmongkol Mathuros Ruchirawat Eytan Ruppin Tim F. Greten Xin Wei Wang
author_facet	Man Hsin Hung Joo Sang Lee Chi Ma Laurence P. Diggs Sophia Heinrich Ching Wen Chang Lichun Ma Marshonna Forgues Anuradha Budhu Jittiporn Chaisaingmongkol Mathuros Ruchirawat Eytan Ruppin Tim F. Greten Xin Wei Wang
author_sort	Man Hsin Hung
title	Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma
title_short	Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma
title_full	Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma
title_fullStr	Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma
title_full_unstemmed	Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma
title_sort	tumor methionine metabolism drives t-cell exhaustion in hepatocellular carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/a4410c080725408d9c0d3f511de3fd95
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Tumor methionine metabolism drives T-cell exhaustion in hepatocellular carcinoma

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