Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate.

The mortality rates of COVID-19 vary widely across countries, but the underlying mechanisms remain unelucidated. We aimed at the elucidation of relationship between gut microbiota and the mortality rates of COVID-19 across countries. Raw sequencing data of 16S rRNA V3-V5 regions of gut microbiota in...

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Autores principales:	Masaaki Hirayama, Hiroshi Nishiwaki, Tomonari Hamaguchi, Mikako Ito, Jun Ueyama, Tetsuya Maeda, Kenichi Kashihara, Yoshio Tsuboi, Kinji Ohno
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/a4427b6e874647a68ff3451e2dcb739f
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spelling	oai:doaj.org-article:a4427b6e874647a68ff3451e2dcb739f2021-12-02T20:16:12ZIntestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate.1932-620310.1371/journal.pone.0260451https://doaj.org/article/a4427b6e874647a68ff3451e2dcb739f2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0260451https://doaj.org/toc/1932-6203The mortality rates of COVID-19 vary widely across countries, but the underlying mechanisms remain unelucidated. We aimed at the elucidation of relationship between gut microbiota and the mortality rates of COVID-19 across countries. Raw sequencing data of 16S rRNA V3-V5 regions of gut microbiota in 953 healthy subjects in ten countries were obtained from the public database. We made a generalized linear model (GLM) to predict the COVID-19 mortality rates using gut microbiota. GLM revealed that low genus Collinsella predicted high COVID-19 mortality rates with a markedly low p-value. Unsupervised clustering of gut microbiota in 953 subjects yielded five enterotypes. The mortality rates were increased from enterotypes 1 to 5, whereas the abundances of Collinsella were decreased from enterotypes 1 to 5 except for enterotype 2. Collinsella produces ursodeoxycholate. Ursodeoxycholate was previously reported to inhibit binding of SARS-CoV-2 to angiotensin-converting enzyme 2; suppress pro-inflammatory cytokines like TNF-α, IL-1β, IL-2, IL-4, and IL-6; have antioxidant and anti-apoptotic effects; and increase alveolar fluid clearance in acute respiratory distress syndrome. Ursodeoxycholate produced by Collinsella may prevent COVID-19 infection and ameliorate acute respiratory distress syndrome in COVID-19 by suppressing cytokine storm syndrome.Masaaki HirayamaHiroshi NishiwakiTomonari HamaguchiMikako ItoJun UeyamaTetsuya MaedaKenichi KashiharaYoshio TsuboiKinji OhnoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0260451 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masaaki Hirayama Hiroshi Nishiwaki Tomonari Hamaguchi Mikako Ito Jun Ueyama Tetsuya Maeda Kenichi Kashihara Yoshio Tsuboi Kinji Ohno Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate.
description	The mortality rates of COVID-19 vary widely across countries, but the underlying mechanisms remain unelucidated. We aimed at the elucidation of relationship between gut microbiota and the mortality rates of COVID-19 across countries. Raw sequencing data of 16S rRNA V3-V5 regions of gut microbiota in 953 healthy subjects in ten countries were obtained from the public database. We made a generalized linear model (GLM) to predict the COVID-19 mortality rates using gut microbiota. GLM revealed that low genus Collinsella predicted high COVID-19 mortality rates with a markedly low p-value. Unsupervised clustering of gut microbiota in 953 subjects yielded five enterotypes. The mortality rates were increased from enterotypes 1 to 5, whereas the abundances of Collinsella were decreased from enterotypes 1 to 5 except for enterotype 2. Collinsella produces ursodeoxycholate. Ursodeoxycholate was previously reported to inhibit binding of SARS-CoV-2 to angiotensin-converting enzyme 2; suppress pro-inflammatory cytokines like TNF-α, IL-1β, IL-2, IL-4, and IL-6; have antioxidant and anti-apoptotic effects; and increase alveolar fluid clearance in acute respiratory distress syndrome. Ursodeoxycholate produced by Collinsella may prevent COVID-19 infection and ameliorate acute respiratory distress syndrome in COVID-19 by suppressing cytokine storm syndrome.
format	article
author	Masaaki Hirayama Hiroshi Nishiwaki Tomonari Hamaguchi Mikako Ito Jun Ueyama Tetsuya Maeda Kenichi Kashihara Yoshio Tsuboi Kinji Ohno
author_facet	Masaaki Hirayama Hiroshi Nishiwaki Tomonari Hamaguchi Mikako Ito Jun Ueyama Tetsuya Maeda Kenichi Kashihara Yoshio Tsuboi Kinji Ohno
author_sort	Masaaki Hirayama
title	Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate.
title_short	Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate.
title_full	Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate.
title_fullStr	Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate.
title_full_unstemmed	Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate.
title_sort	intestinal collinsella may mitigate infection and exacerbation of covid-19 by producing ursodeoxycholate.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/a4427b6e874647a68ff3451e2dcb739f
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Intestinal Collinsella may mitigate infection and exacerbation of COVID-19 by producing ursodeoxycholate.

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