Deletion of the SELENOP gene leads to CNS atrophy with cerebellar ataxia in dogs.

Deletion of the SELENOP gene leads to CNS atrophy with cerebellar ataxia in dogs.

We investigated a hereditary cerebellar ataxia in Belgian Shepherd dogs. Affected dogs developed uncoordinated movements and intention tremor at two weeks of age. The severity of clinical signs was highly variable. Histopathology demonstrated atrophy of the CNS, particularly in the cerebellum. Combi...

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Detalles Bibliográficos
Autores principales: Matthias Christen, Sandra Högler, Miriam Kleiter, Michael Leschnik, Corinna Weber, Denise Thaller, Vidhya Jagannathan, Tosso Leeb
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2021
Materias:
Genetics
QH426-470
Acceso en línea:https://doaj.org/article/a4433329618249db880debd806cd5ddf
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