24-hour intraocular pressure in glaucoma patients randomized to receive dorzolamide or brinzolamide in combination with latanoprost

Yoshimi Nakamura, Shusaku Ishikawa, Yuko Nakamura, Hiroshi Sakai, Ichiko Henzan, Shoichi SawaguchiDepartment of Ophthalmology, University of the Ryukyus Faculty of Medicine, Okinawa, JapanPurpose: To investigate the efficacy of dorzolamide 1% (bid or tid) or brinzolamide 1% bid on 24-hour intraocula...

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Autores principales:	Yoshimi Nakamura, Shusaku Ishikawa, Yuko Nakamura, Hiroshi Sakai, et al.
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/a443baba7c184a2cb7f19947c8e4c7d1
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spelling	oai:doaj.org-article:a443baba7c184a2cb7f19947c8e4c7d12021-12-02T05:27:53Z24-hour intraocular pressure in glaucoma patients randomized to receive dorzolamide or brinzolamide in combination with latanoprost1177-54671177-5483https://doaj.org/article/a443baba7c184a2cb7f19947c8e4c7d12009-07-01T00:00:00Zhttp://www.dovepress.com/24-hour-intraocular-pressure-in-glaucoma-patients-randomized-to-receiv-a3321https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Yoshimi Nakamura, Shusaku Ishikawa, Yuko Nakamura, Hiroshi Sakai, Ichiko Henzan, Shoichi SawaguchiDepartment of Ophthalmology, University of the Ryukyus Faculty of Medicine, Okinawa, JapanPurpose: To investigate the efficacy of dorzolamide 1% (bid or tid) or brinzolamide 1% bid on 24-hour intraocular pressure (IOP) control as well as patients&rsquo; preference for either drug when added in combination with latanoprost against glaucoma (IOP, &ge;18 mmHg).Methods: In this randomized crossover study patients were assigned to receive latanoprost plus either dorzolamide or brinzolamide for four weeks. Thereafter, patients underwent 24-hour IOP monitoring while continuing to receive dorzolamide (for two successive days/nights: at first bid then tid) or brinzolamide bid (once overnight). They were then switched over to receive the other test medication for a further four weeks and subsequently reexamined for 24-hour IOP. A questionnaire survey on treatment satisfaction was performed.Results: In 20 patients dorzolamide bid or tid or brinzolamide bid exerted significant (p &lt; 0.001) reductions of IOP from baseline at all time-points over 24 hours; no difference was detected among the treatment regimens. Significantly (p &lt; 0.05) more patients preferred dorzolamide (n = 9) over brinzolamide (n = 2), whereas nine patients gave a neutral answer. Conclusion: Dorzolamide bid or tid and brinzolamide bid when combined with latanoprost therapy elicited significant IOP reduction for 24 hours. It is rational to consider patients&rsquo; preference of therapeutic regimen especially long-term users such as those with glaucoma.Keywords: glaucoma, brinzolamide, dorzolamide, latanoprost combination therapy, 24-hour intraocular pressure (IOP), questionnaire survey Yoshimi NakamuraShusaku IshikawaYuko NakamuraHiroshi Sakaiet al.Dove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2009, Iss default, Pp 395-400 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Yoshimi Nakamura Shusaku Ishikawa Yuko Nakamura Hiroshi Sakai et al. 24-hour intraocular pressure in glaucoma patients randomized to receive dorzolamide or brinzolamide in combination with latanoprost
description	Yoshimi Nakamura, Shusaku Ishikawa, Yuko Nakamura, Hiroshi Sakai, Ichiko Henzan, Shoichi SawaguchiDepartment of Ophthalmology, University of the Ryukyus Faculty of Medicine, Okinawa, JapanPurpose: To investigate the efficacy of dorzolamide 1% (bid or tid) or brinzolamide 1% bid on 24-hour intraocular pressure (IOP) control as well as patients&rsquo; preference for either drug when added in combination with latanoprost against glaucoma (IOP, &ge;18 mmHg).Methods: In this randomized crossover study patients were assigned to receive latanoprost plus either dorzolamide or brinzolamide for four weeks. Thereafter, patients underwent 24-hour IOP monitoring while continuing to receive dorzolamide (for two successive days/nights: at first bid then tid) or brinzolamide bid (once overnight). They were then switched over to receive the other test medication for a further four weeks and subsequently reexamined for 24-hour IOP. A questionnaire survey on treatment satisfaction was performed.Results: In 20 patients dorzolamide bid or tid or brinzolamide bid exerted significant (p &lt; 0.001) reductions of IOP from baseline at all time-points over 24 hours; no difference was detected among the treatment regimens. Significantly (p &lt; 0.05) more patients preferred dorzolamide (n = 9) over brinzolamide (n = 2), whereas nine patients gave a neutral answer. Conclusion: Dorzolamide bid or tid and brinzolamide bid when combined with latanoprost therapy elicited significant IOP reduction for 24 hours. It is rational to consider patients&rsquo; preference of therapeutic regimen especially long-term users such as those with glaucoma.Keywords: glaucoma, brinzolamide, dorzolamide, latanoprost combination therapy, 24-hour intraocular pressure (IOP), questionnaire survey
format	article
author	Yoshimi Nakamura Shusaku Ishikawa Yuko Nakamura Hiroshi Sakai et al.
author_facet	Yoshimi Nakamura Shusaku Ishikawa Yuko Nakamura Hiroshi Sakai et al.
author_sort	Yoshimi Nakamura
title	24-hour intraocular pressure in glaucoma patients randomized to receive dorzolamide or brinzolamide in combination with latanoprost
title_short	24-hour intraocular pressure in glaucoma patients randomized to receive dorzolamide or brinzolamide in combination with latanoprost
title_full	24-hour intraocular pressure in glaucoma patients randomized to receive dorzolamide or brinzolamide in combination with latanoprost
title_fullStr	24-hour intraocular pressure in glaucoma patients randomized to receive dorzolamide or brinzolamide in combination with latanoprost
title_full_unstemmed	24-hour intraocular pressure in glaucoma patients randomized to receive dorzolamide or brinzolamide in combination with latanoprost
title_sort	24-hour intraocular pressure in glaucoma patients randomized to receive dorzolamide or brinzolamide in combination with latanoprost
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/a443baba7c184a2cb7f19947c8e4c7d1
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24-hour intraocular pressure in glaucoma patients randomized to receive dorzolamide or brinzolamide in combination with latanoprost

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